Walsh & Hoyt: Pathogenesis

The prevailing hypothesis that ADEM results from a Tcellmediated immune response to myelin is based historically on comparative pathology. The acute perivenular inflammatory response with demyelination resembles the brain lesion that complicates rabies vaccine prepared in neural tissues and is seen in the disorder called experimental allergic encephalomyelitis that can be produced in a variety of species by a single injection of neural tissue mixed with Freunds adjuvant. Indeed, all three conditions have a similar latency in onset, clinical course, and pathology