Bilateral Optic Neuropathy after Bone Marrow Transplant

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Identifier walsh_1999_s4_c1
Title Bilateral Optic Neuropathy after Bone Marrow Transplant
Creator Anthony C. Arnold, MD; Matthew Y. Wang, MD; Harry V. Vinters, MD; Robert S. Hepler, MD; Ben J. Glasgow, MD
Affiliation Stein Eye Institute, Los Angeles, CA
Subject Bone Marrow Transplantation; Neurotoxicity Syndromes; Optic Neuropathy, Ischemic; Necrosis; Pupil Disorders
History A 48-year old female diagnosed with poorly differentiated infiltrating ductal breast carcinoma. Surgical excision and axillary node dissection of nodes with localized chest wall and tumor bed irradiation. Axillary metastasis treated with chemotherapy and autologous bone marrow transplant. A rapid onset of visual loss OD afterwards.
Pathology Optic nerve necrosis; Occulsive vasculopathy of retina
Disease/Diagnosis Multifocal optic nerve, retina, brain and CNS necrosis neurotoxic exposure to chemotherapeutic agents
Clinical VA: 20/30 OD, 20/400 OS; RAPD OS; BRAO OD
Neuroimaging MRI
Treatment Antineoplastic agents
Date 1999
References 1. Walsh TJ, Clark AW, Parhad IM, et ah Neurotoxic effects of cisplatin therapy. Arch Neurol 1982;39:719-720. 2. Shingleton BJ, Bienfang DC, Albert DM, et ah Ocular toxicity associated with high-dose carmustine. Arch Ophthalmol 1982;100:1766-1772. 3. Rubin P, Hulette C, Khawley JA, et ah Ocular toxicity following high dose chemotherapy and autologous transplant. Bone Marrow Transplantation 1996;18:253-256. 4. Khawley J A, Rubin P, Petros W, et al Retinopathy and optic neuropathy in bone marrow transplantation for breast cancer. Ophthalmology 1996;103:87-95. 5. Arnold AC: Optic neuropathy and retinopathy after bone marrow transplantation. Neuro-OphthaImology 1998;20 (Suppl):9.
Language eng
Format application/pdf
Type Text
Relation is Part of 1999 Walsh Session, February 6-7.
Collection Neuro-Ophthalmology Virtual Education Library: Walsh Session Annual Meeting Archives: https://novel.utah.edu/Walsh/
Publisher North American Neuro-Ophthalmology Society
Holding Institution Spencer S. Eccles Health Sciences Library, University of Utah
Rights Management Copyright 2008. For further information regarding the rights to this collection, please visit: https://NOVEL.utah.edu/about/copyright
ARK ark:/87278/s68k7cv8
Setname ehsl_novel_fbw
ID 178103
Reference URL https://collections.lib.utah.edu/ark:/87278/s68k7cv8
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