Molecular dynamics simulations on G-quadruplexes

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Title Molecular dynamics simulations on G-quadruplexes
Publication Type dissertation
School or College College of Pharmacy
Department Medicinal Chemistry
Author Cang, Xiaohui
Date 2010-12
Description Guanine-rich DNA/RNA sequences have the potential to form four-stranded structures called G-quadruplexes. Because of the rigidity and glycosidic bond orientation diversity in the stems, the flexibility of loops, and the featured alignment of several cations within one quadruplex channel, G-quadruplexes can serve as a sensitive benchmark to assess and validate current force fields for nucleic acids in molecular dynamics (MD) simulations.
Type Text
Publisher University of Utah
Subject AMBER; DNA; Glycosidic conformation; G-quadruplex; Molecular dynamics; Structural polymorphism
Subject LCSH Quadruplex nucleic acids; Molecular dynamics
Dissertation Institution University of Utah
Dissertation Name PhD
Language eng
Rights Management © Xiaohui Cang
Format application/pdf
Format Medium application/pdf
Source Original in Marriott Library Special collections, QP6.5 2010 .C255
ARK ark:/87278/s6697j7w
Setname ir_etd
ID 194086
Reference URL https://collections.lib.utah.edu/ark:/87278/s6697j7w
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