Characterization of proteins regulating vesicular trafficking and protein sorting

The endocytic apparatus, a series of vesicular compartments that exist in dynamic equilibrium through fusion and fission events, provides a mechanism for the movement of molecules within the cell. Newly synthesized molecules are trafficked from the Golgi to their functional location and internalized molecules are delivered to the lysosome/vacuole for degradation. Many proteins are required to maintain the appropriate trafficking of molecules and the size and number of vesicles. This dissertation identifies and characterizes proteins that function within the later portion of the endocytic pathway. The <italic>Saccharomyces cerevisiae