Impact of an Antimicrobial Stewardship Intervention in Patients with Uncomplicated Gram-Negative Bacteraemia

Background: Recent studies in Gram-negative bacteremia (GNB) suggest treatment with oral (PO) antibiotics after initial intravenous (IV) therapy and short treatment durations yield similar clinical outcomes and fewer adverse events. Antimicrobial stewardship program (ASP) bundled initiatives have been associated with improved clinical outcomes for blood stream infections, especially when combined with rapid diagnostic testing (RDT). This study aimed to evaluate the impact of ASP bundled interventions in patients with GNB.