Intravitreal Injection Of Bevacizumab May Be Neuroprotective In A Mouse Model Of Optic Nerve Crush

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Identifier 20130211_nanos_sciplatform1_07
Title Intravitreal Injection Of Bevacizumab May Be Neuroprotective In A Mouse Model Of Optic Nerve Crush
Creator Daniel Rappoport; Dana Morzaev Morzaev; Shirel Weiss; Mark Vieyra; Hana Leiba; Nitza Goldenberg-Cohen
Affiliation (DR) (HL) Ophthalmology Department, Kaplan Medical Center, Rehovot, Israel; (DMM) (SW) (NGC) The Krieger Eye Research Laboratory, Felsenstein Medical Research Center, Petah Tiqwa, Israel; (DMM) (SW) (MV) (NGC) Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel; (HL) Hadassah and Hebrew University Medical School, Jerusalem, Israel; (NGC) Pediatric Unit, Ophthalmology Department,Schneider Children's Medical Center of Israel, Petah Tiqwa, Israel
Subject Bevacizumab; Optic Neuropathy; Neuroprotective; Mouse Model
Description Disk edema may exacerbate axonal damage in acute optic neuropathy. Bevacizumab (Avastin) inhibits the signaling of Vascular Endothelial Growth Factor (VEGF), thereby potentially reducing the vasogenic edema of the disk. The aim of this study was to evaluate the effect of an intravitreal injection of bevazicumab on optic nerve edema and RGC loss in a mouse model of optic nerve crush (ONC).
Date 2013-02-11
Language eng
Format application/pdf
Type Text
Source 2013 North American Neuro-Ophthalmology Society Annual Meeting
Relation is Part of NANOS 2013: Platform Presentations (Session I)
Collection Neuro-Ophthalmology Virtual Education Library: NANOS Annual Meeting Collection: https://novel.utah.edu/collection/nanos-annual-meeting-collection/
Publisher North American Neuro-Ophthalmology Society
Holding Institution Spencer S. Eccles Health Sciences Library, University of Utah
Rights Management Copyright 2013. For further information regarding the rights to this collection, please visit: https://NOVEL.utah.edu/about/copyright
ARK ark:/87278/s6tf341p
Setname ehsl_novel_nam
ID 183436
Reference URL https://collections.lib.utah.edu/ark:/87278/s6tf341p
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