The Efficacy of doxycycline as a single-session oral medication in the treatment of uncomplicated gonorrhea.

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Title The Efficacy of doxycycline as a single-session oral medication in the treatment of uncomplicated gonorrhea.
Publication Type thesis
School or College School of Medicine
Department Family & Preventive Medicine
Author Mathews, Kenneth Milton
Date 1981-03
Description Review of the medical literature on the treatment of gonorrhea indicates penicillin G may have reached its peak of effectiveness due to the relative high resistance of the gonococci to it. Doxycycline had been investigated in this study to ascertain if it is at least as effective as penicillin G and to ascertain if its side effects proscribe its use. A randomized prospective study was conducted on 237 subjects identified as having a positive culture for N. Gonorrhea and were assigned to one of two regime; Doxycycline 600 mg orally in a divided dose one hour apart and aqueous procaine penicillin G 4.8 million unites intramuscularly with one gram of probenecid orally. There were no treatment failures in 141 subjects treated with penicillin G and no reported side effects except the localized pain of injection. There were two treatment failures in 96 subjects treated with Doxycycline and two reported cases with side effects, on with nausea and one with diarrhea (X2=3.08m p>0.05). The minimum inhibitory concentrations of penicillin G and Doxycycline for the gonococenl isolates indicated no reduction in resistance to penicillin, G, but a reduction in resistance to the tetracyclines. This study concludes that doxycycline is as effective as penicillin G in the treatment of gonorrhea. While the side effects of the antibiotics may have been under-reported, these were not enough to proscribe the use of doxycycline. Finally, the decreased resistance of the gonococci to the tetracyclines indicates it may be the preferred treatment for gonorrhea instead of penicillin G.
Type Text
Publisher University of Utah
Subject Therapy; Antibiotic Testing
Subject MESH Doxycycline; Gonorrhea
Dissertation Institution University of Utah
Dissertation Name MPH
Language eng
Relation is Version of Digital reproduction of "The Efficacy of doxycycline as a single-session oral medication in the treatment of uncomplicated gonorrhea." Spencer S. Eccles Health Sciences Library. Print version of "The Efficacy of doxycycline as a single-session oral medication in the treatment of uncomplicated gonorrhea." available at J. Willard Marriott Library Special Collection. RM 31.5 1981 M38.
Rights Management © Kenneth Milton Mathew
Format application/pdf
Format Medium application/pdf
Identifier us-etd2,9428
Source Original: University of Utah Spencer S. Eccles Health Sciences Library (no longer available).
ARK ark:/87278/s6j10hrw
Setname ir_etd
ID 193233
Reference URL https://collections.lib.utah.edu/ark:/87278/s6j10hrw
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