Suppression of pulmonary antibacterial activity by virus infection

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Title Suppression of pulmonary antibacterial activity by virus infection
Publication Type thesis
School or College School of Medicine
Department Pathology
Author Taylor, Roger Norris
Contributor Olsen, Donna; Mueller, Laura
Date 1971-06
Description Resistance to bacterial pneumonia may be impaired by a pre-existing virus infection. It has been proposed that this is due to an effect the virus has on the phagocytic and cytopeptic capacities of the alveolar macrophages. Guinea pigs were exposed to influenza Al virus in a Tri-R airborne infection chamber. The alveolar and peritonea macrophages were harvested and allowed to attach to the flat surfact of Leighton tubes. These macrophages were then challenged with a suspension of Klebsiella pneumoniae for 2 hours. The macrophages were washed free of extracellular bacteria and antibiotics were added to prevent extracellular multiplication. Plate counts were made at various time intervals on disrupted macrophages to determine the number of viable intracellular bacteria remaining. The samples counted immediately after the 2 hour challenge were considered to represent phagocytosis and those counted at various times following removal of extracellular bacteria were considered to be indicators of either cytopepsrs or intracellular multiplication. In vivo virus exposed macrophages ingested the bacteria at a rate significantly greater (p <.05) than that of non-virus exposed, control macrophages. However, virus exposed macrophages exhibited significantly reduced cytopepsis (p <.01) as compared to controls. These effects were observed in both the alveolar and peritoneal macrophages. It seems that virus infection may reduce host resistance to pulmonary bacterial infection by interfering with intracellular digestion of the ingested bacteria.
Type Text
Publisher University of Utah
Subject Macrophages; Pneumonia
Subject MESH Microbiology; Pneumonia; Virus Diseases
Dissertation Institution University of Utah
Dissertation Name MS
Language eng
Relation is Version of Digital reproduction of "Suppression of pulmonary antibacterial activity by virus infection". Spencer S. Eccles Health Sciences Library.
Rights Management © Roger Norris Taylor.
Format application/pdf
Format Medium application/pdf
Format Extent 1,106,915 bytes
Identifier undthes,4250
Source Original: University of Utah Spencer S. Eccles Health Sciences Library (no longer available)
Master File Extent 1,106,955 bytes
ARK ark:/87278/s6zw1nnx
Setname ir_etd
ID 190490
Reference URL https://collections.lib.utah.edu/ark:/87278/s6zw1nnx
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