Prevalence of Diabetic Retinopathy in a Population of Diabetics From the Middle East With Microvascular Ocular Motor Palsies

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Title Prevalence of Diabetic Retinopathy in a Population of Diabetics From the Middle East With Microvascular Ocular Motor Palsies
Creator Alberto Gálvez-Ruiz, PhD; Patrik Schatz, MD, PhD
Affiliation Neuro-ophthalmology Division (AG-R), King Khaled Eye Specialist Hospital, Riyadh, Saudi Arabia; Retina Division (PS), King Khaled Eye Specialist Hospital, Riyadh, Saudi Arabia; and Department of Ophthalmology (PS), Clinical Sciences, Scane County University Hospital, University of Lund, Lund, Sweden
Abstract Loss of retinal ganglion cell-inner plexiform layer (GCIPL) thickness has been shown in different optic neuropathies. In this study, we evaluated the capability of GCIPL analysis by optical coherence tomography (OCT) to detect early neuronal loss during the time course of nonarteritic anterior ischemic optic neuropathy (NAION).; ; Twenty-four patients with unilateral NAION participated in this prospective, comparative study. Affected and unaffected eyes underwent spectral domain OCT measurement of the retinal nerve fiber layer (RNFL), total macula, and GCIPL thicknesses. These measurements were recorded in the acute phase (within 7 days) and at 1, 3, and 6 months.; ; At the initial presentation and 1, 3, and 6 months, the mean RNFL thickness in the NAION eyes was 236.5 μm ± 74.2, 157.1 μm ± 45.7, 61.4 μm ± 6.1, and 55.0 μm ± 19.5, respectively. Similar to RNFL, thinning of the mean total macular thickness in inner and outer rings started after 3 months and thicknesses decreased to 307.7 μm ± 15.3 and 273.1 μm ± 21.2 after 3 months and to 309.1 μm ± 15.0 and 273.4 μm ± 13.8 after 6 months, compared with unaffected contralateral eyes, respectively (all P < 0.0001). Thinning of the GCIPL was first evident in the affected NAION eyes at 1 month, and the mean inner and outer GCIPL thicknesses were 62.8 μm ± 14.6 and 53.9 μm ± 7.2 at 1 month in the NAION eyes compared with unaffected eyes (P < 0.001). After 3 and 6 months, the inner and outer GCIPL thicknesses were 51.1 μm ± 8.1 and 47.4 μm ± 5.31, and 50.6 μm ± 11.5 and 47.9 μm ± 5.6, respectively.; ; Thinning of the GCIPL is first detectable at 1 month after NAION and persists for 3 months. GCIPL thinning occurs before RFNL thinning in NAION.
Subject Adult; Older people; Female; Follow-Up Studies; Humans; Male; Middle Older people; Nerve Fibers; Optic Disk; Optic Neuropathy, Ischemic; Prospective Studies; Retinal Ganglion Cells; Time Factors; Tomography, Optical Coherence; Visual Acuity
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Date 2016-06
Language eng
Format application/pdf
Type Text
Publication Type Journal Article
Source Journal of Neuro-Ophthalmology, June 2016, Volume 36, Issue 2
Collection Neuro-Ophthalmology Virtual Education Library: Journal of Neuro-Ophthalmology Archives: https://novel.utah.edu/jno/
Publisher Lippincott, Williams & Wilkins
Holding Institution Spencer S. Eccles Health Sciences Library, University of Utah
Rights Management © North American Neuro-Ophthalmology Society
ARK ark:/87278/s6jx28d7
Setname ehsl_novel_jno
ID 1276487
Reference URL https://collections.lib.utah.edu/ark:/87278/s6jx28d7
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