Safety and Tolerability of Acetazolamide in the Idiopathic Intracranial Hypertension Treatment Trial

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Title Safety and Tolerability of Acetazolamide in the Idiopathic Intracranial Hypertension Treatment Trial
Creator Martin W. ten Hove, MD; Deborah I. Friedman, MD; Anil D. Patel, MD; Isabella Irrcher, PhD; Michael Wall, MD; Michael P. McDermott, PhD; for the NORDIC Idiopathic Intracranial Hypertension Study Group
Affiliation Department of Ophthalmology (MWtH, II), Queen's University and Hotel Dieu Hospital, Kingston, Ontario, Canada; Departments of Neurology and Neurotherapeutics and Ophthalmology (DIF), University of Texas Southwestern Medical Center, Dallas, Texas; Department of Ophthalmology (ADP), Dean McGee Eye Institute, University of Oklahoma, Oklahoma City, Oklahoma; Department of Neurology (MW), University of Iowa, Iowa City, Iowa; and Department of Biostatistics and Computational Biology (MPM), University of Rochester, Rochester, New York; NORDIC Idiopathic Intracranial Hypertension Study Group
Abstract The impact of prior neuro-ophthalmic syndromes on the performance on vision-based neuropsychological tasks in patients with multiple sclerosis (MS) is unknown. Two groups of MS participants, one with (Msos+) and the other without (Msos-), a history of neuro-ophthalmic syndromes, underwent neuropsychological assessment and were compared with healthy age- and education-matched controls (HC). Participants with Msos+ performed significantly worse on the symbol digit modalities test than the Msos- (P < 0.03) and the HC groups (P < 0.01) and coding (P < 0.01). A clinical history of neuro-ophthalmic syndromes is associated with reduced performance on visual processing speed tasks.
Subject Acetazolamide; Adolescent; Adult; Carbonic Anhydrase Inhibitors; Combined Modality Therapy; Diet, Sodium-Restricted; Double-Blind Method; Female; Humans; Intracranial Pressure; Male; Maximum Tolerated Dose; Middle Older people; Papilledema; Pseudotumor Cerebri; Quality of Life; Vision Disorders; Visual Fields
OCR Text Show
Date 2016-03
Language eng
Format application/pdf
Type Text
Publication Type Journal Article
Collection Neuro-Ophthalmology Virtual Education Library: Journal of Neuro-Ophthalmology Archives: https://novel.utah.edu/jno/
Publisher Lippincott, Williams & Wilkins
Holding Institution Spencer S. Eccles Health Sciences Library, University of Utah
Rights Management © North American Neuro-Ophthalmology Society
ARK ark:/87278/s6qr8rmt
Setname ehsl_novel_jno
ID 1276447
Reference URL https://collections.lib.utah.edu/ark:/87278/s6qr8rmt
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