Paraneoplastic Optic Neuropathy and Pineal Germinoma With Collapsin Response-Mediating Protein Antibodies

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Title Paraneoplastic Optic Neuropathy and Pineal Germinoma With Collapsin Response-Mediating Protein Antibodies
Creator Shripaad Y. Shukla, MD; John H. Pula, MD; Samira Khan, MD; John M. Lee, MD, PhD
Affiliation Departments of Ophthalmology and Visual Sciences (SYS), The University of Chicago, Chicago, Illinois; Department of Ophthalmology (SYS), Dean McGee Eye Institute, University of Oklahoma, Oklahoma City, Oklahoma; Department of Neurology (JHP), NorthShore University Health System, Glenview, Ilinois; Departments of Ophthalmology and Visual Sciences (SK), NorthShore University Health System, Glenview, Illinois; and Department of Pathology (JML), NorthShore University Health System, Evanston, Illinois
Abstract Spontaneous recovery of visual loss resulting from injury to the brain is variable. A variety of traditional rehabilitative strategies, including the use of prisms or compensatory saccadic eye movements, have been used successfully to improve visual function and quality-of-life for patients with homonymous hemianopia. More recently, repetitive visual stimulation of the blind area has been reported to be of benefit in expanding the field of vision. We performed a literature review with main focus on clinical studies spanning from 1963 to 2016, including 52 peer-reviewed articles, relevant cross-referenced citations, editorials, and reviews. Repetitive visual stimulation is reported to expand the visual field, although the interpretation of results is confounded by a variety of methodological factors and conflicting outcomes from different research groups. Many studies used subjective assessments of vision and did not include a sufficient number of subjects or controls. The available clinical evidence does not strongly support claims of visual restoration using repetitive visual stimulation beyond the time that spontaneous visual recovery might occur. This lack of firm supportive evidence does not preclude the potential of real benefit demonstrated in laboratories. Additional well-designed clinical studies with adequate controls and methods to record ocular fixation are needed.
Subject Adolescent; Autoantibodies; Biomarkers, Tumor; Blotting, Western; Brain Neoplasms; Germinoma; Humans; Immunohistochemistry; Magnetic Resonance Imaging; Male; Nerve Tissue Proteins; Optic Nerve Diseases; Paraneoplastic Syndromes, Ocular; Pineal Gland; Pinealoma
OCR Text Show
Date 2018-06
Language eng
Format application/pdf
Type Text
Publication Type Journal Article
Source Journal of Neuro-Ophthalmology, June 2018, Volume 38, Issue 2
Collection Neuro-Ophthalmology Virtual Education Library: Journal of Neuro-Ophthalmology Archives: https://novel.utah.edu/jno/
Publisher Lippincott, Williams & Wilkins
Holding Institution Spencer S. Eccles Health Sciences Library, University of Utah
Rights Management © North American Neuro-Ophthalmology Society
ARK ark:/87278/s68d4gk2
Setname ehsl_novel_jno
ID 1452576
Reference URL https://collections.lib.utah.edu/ark:/87278/s68d4gk2
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