Predictive Approaches to Treatment effect Heterogeneity (PATH): A secondary analysis of the HCRN Entry Site Trial

Hydrocephalus is a condition in which excess cerebrospinal fluid (CSF) builds up in the brain or spine. Though some CSF is necessary for the brain to function normally, too much CSF can be harmful. For some, the impacts of this disease are mild, such as headaches or nausea. However, for others, hydrocephalus can reduce brain function or even be fatal.1 For many patients, hydrocephalus is present from birth. Hydrocephalus in infants may be caused by genetic or developmental factors, premature birth, or illness. Meanwhile, hydrocephalus in adults is most often caused by injury or other mechanisms resulting in damage to the brain.