Pharmacokinetics and dosage adjustment of netilmicin in patients with cystic fibrosis

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Title Pharmacokinetics and dosage adjustment of netilmicin in patients with cystic fibrosis
Publication Type dissertation
School or College College of Pharmacy
Department Pharmacotherapy
Author Townsend, Paula Lynn
Date 1984-06
Description Netilmicin is a semisynthetic aminoglycoside antibiotic recently marketed in the United States by Schering-Plouogh corporation as Netromycin. The mechanism and spectrum of antibacterial action of netilmicin are similar to those of other aminoglycosides. Pulmonary infections with Pseudomonas aeruginosa are a common complication in patients with cystic fibrosis. Aminoglycosides currently occupy a central role in the management of these infections, often in combination with an extended spectrum penicillin derivative. Thadepalli, et al have demonstrated the synergism of netilmicin in combination with carbenicillan, ticarcillin and piperacillin to inhibit a number of Pseudomonas aeruginosa strains. Netilmicin may therefore play a role in the treatment of these infections. The objectives of this study were to further extend the limited information available on the elimination pharmacokinetics of netilmicin in patients with cystic fibrosis and to determine the utility of the Sawchuk-Zaske method of dosage adjustment for netilmicin in this population.
Type Text
Publisher University of Utah
Subject MESH Research Design; Cystic Fibrosis; Aminoglycosides; Netilmicin; Anti-Bacterial Agents; Pharmacokinetics; Lung Diseases; Pseudomonas; Microbial Sensitivity Tests; Serum; Bayes Theorem; Drug Monitoring; Drug Administration Schedule
Dissertation Institution University of Utah
Dissertation Name Doctor of Pharmacy
Language eng
Relation is Version of Digital reproduction of Pharmacokinetics and dosage adjustment of netilmicin in patients with cystic fibrosis
Rights Management Copyright © Paula Lynn Townsend 1984
Format application/pdf
Format Medium application/pdf
ARK ark:/87278/s69c7c9b
Setname ir_etd
ID 195918
Reference URL https://collections.lib.utah.edu/ark:/87278/s69c7c9b
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