Visual Recovery in 2 Cases of Central Retinal Artery Occlusion Treated With Prompt Intra-ophthalmic Artery Fibrinolysis

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Title Visual Recovery in 2 Cases of Central Retinal Artery Occlusion Treated With Prompt Intra-ophthalmic Artery Fibrinolysis
Creator Laura Donaldson; Patrick Nicholson; Edward Margolin
Affiliation Division of Ophthalmology (LD), Department of Surgery, McMaster University, Hamilton, Canada ; and Department of Medical Imaging (PN), University Health Network, Department of Ophthalmology and Vision Sciences (EM), Faculty of Medicine, Division of Neurology (EM), Department of Medicine, Faculty of Medicine, University of Toronto, Toronto, Canada
Abstract Background: Central retinal artery occlusion (CRAO) rapidly produces inner retinal ischemia and irreversible vision loss. Although many therapeutic interventions have been proposed, no interventions have proven effective in restoring vision in large randomized controlled trials and final visual outcome in most patients is very poor. Methods: Retrospective case series. Results: We describe 2 cases of CRAO occurring after uncomplicated cataract surgery under topical anesthesia and rapidly diagnosed. Both had very severe vision loss at presentation with dramatic improvement after intra-ophthalmic artery fibrinolysis administered 2.75 and 5.5 hours after symptom onset. Conclusions: Sudden monocular vision loss is an ophthalmologic emergency as CRAO must be ruled out and if diagnosed, rapid intervention should be performed. Devastating vision loss can be prevented if interventional neuroradiology is trained and available on a 24-hour basis for administration of local intra-arterial thrombolysis.
Subject Fibrinolysis; Humans; Ophthalmic Artery / diagnostic imaging; Retinal Artery Occlusion / diagnosis; Retinal Artery Occlusion / drug therapy; Retrospective Studies; Thrombolytic Therapy; Treatment Outcome; Visual Acuity
OCR Text Show
Date 2023-09
Date Digital 2023-09
Language eng
Format application/pdf
Type Text
Publication Type Journal Article
Source Journal of Neuro-Ophthalmology, September 2023, Volume 43, Issue 3
Collection Neuro-Ophthalmology Virtual Education Library: Journal of Neuro-Ophthalmology Archives: https://novel.utah.edu/jno/
Publisher Lippincott, Williams & Wilkins
Holding Institution Spencer S. Eccles Health Sciences Library, University of Utah
Rights Management © North American Neuro-Ophthalmology Society
ARK ark:/87278/s6z6p2jb
Setname ehsl_novel_jno
ID 2538095
Reference URL https://collections.lib.utah.edu/ark:/87278/s6z6p2jb
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