You Shake My Nerves and You Rattle My Brain
| Identifier | walsh_2007_s1_c4 |
| Title | You Shake My Nerves and You Rattle My Brain |
| Creator | Ai Sakonju; David Newman-Toker, MD, PhD |
| Affiliation | Departments of Neurology, Ophthalmology, & Otolaryngology, The Johns Hopkins University School of Medicine |
| Subject | Antigens, Neoplasm; Testicular Neoplasms; Paraneoplastic Syndromes; Ocular Motility Disorders; Limbic Encephalitis; Hypokinesia; Deglutition Disorders |
| History | A 39-year old male with a progressive inability to perform daily activities, worsening falls and dysphagia presumed to be harbingers of early-onset Parkinson. Previous history significant for traumatic brain injury. |
| Pathology | Positive anti-Ma2 antibody |
| Disease/Diagnosis | Anti-Ma2 paraneoplastic brainstem-limbic encephalitis secondary to embryonal testicular cancer |
| Clinical | Abnormal, intrusive eye movement |
| Presenting Symptom | Bradykinesia; Dysphagia; Social withdrawal; Retropulsive gait |
| Neuroimaging | MRI |
| Treatment | Hormonal antineoplastic agents; IV immunoglobulin |
| Date | 2007-02 |
| References | 1. Castle J, Sakonju A, Dalmau J, Newman-Toker DE, Anti-Ma2-associated encephalitis with normal FDG-PET: a case of pseudo-Whipple's disease, Nature Clinical Practice Neurology, 2 (10), 566-572, 2006. 2. Dalmau J, Graus F, Villargo A, Posner JB, Blumenthal D, Thiessen B, Sarz A, Meneses P, Rosenfeld M, Clinical analysis of anti-Ma 2 associated encephalitis, Brain, 127, 1831-1844, 2004. 3. Gerard A, Sarrot-Reynauld F, Liozon E, Cathebras P, Besson G, Robin C, Vignetto A, Monsnier J, Durieu I, Durand D, Rousset H, Neurologic presentation of Whipple disease: Report of 12 cases and review of the literature, Medicine, 81(6), 443-457, 2002. 4. Louis ED, Lynch T, Kaufman P, Fahn S, Odel J, Diagnostic guidelines in central nervous system Whipple's disease, Annals of Neurology, 40(4), 561-568, 1996. 5. Rosenfeld M, Eichen J, Wade D, Posner J, Dalmau J, Molecular and clinical diversity in paraneoplastic immunity to Ma proteins, Annals of Neurology, 50, 339-348, 2001. |
| Language | eng |
| Format | application/pdf |
| Type | Text |
| Source | 39th Annual Frank Walsh Society Meeting |
| Relation is Part of | NANOS Annual Meeting Frank B. Walsh Sessions; 2007 |
| Collection | Neuro-Ophthalmology Virtual Education Library: Walsh Session Annual Meeting Archives: https://novel.utah.edu/Walsh/ |
| Publisher | North American Neuro-Ophthalmology Society |
| Holding Institution | Spencer S. Eccles Health Sciences Library, University of Utah |
| Rights Management | Copyright 2008. For further information regarding the rights to this collection, please visit: https://NOVEL.utah.edu/about/copyright |
| ARK | ark:/87278/s6k07727 |
| Setname | ehsl_novel_fbw |
| ID | 178302 |
| Reference URL | https://collections.lib.utah.edu/ark:/87278/s6k07727 |