| Identifier |
walsh_1999_s4_c1 |
| Title |
Bilateral Optic Neuropathy after Bone Marrow Transplant |
| Creator |
Anthony C. Arnold, MD, UCLA |
| Subject |
Bone Marrow Transplantation; Neurotoxicity Syndromes; Optic Neuropathy, Ischemic; Necrosis; Pupil Disorders |
| History |
A 48-year old female diagnosed with poorly differentiated infiltrating ductal breast carcinoma. Surgical excision and axillary node dissection of nodes with localized chest wall and tumor bed irradiation. Axillary metastasis treated with chemotherapy and autologous bone marrow transplant. A rapid onset of visual loss OD afterwards. |
| Pathology |
Optic nerve necrosis; Occulsive vasculopathy of retina |
| Disease/Diagnosis |
Multifocal optic nerve, retina, brain and CNS necrosis neurotoxic exposure to chemotherapeutic agents |
| Clinical |
VA: 20/30 OD, 20/400 OS; RAPD OS; BRAO OD |
| Neuroimaging |
MRI |
| Treatment |
Antineoplastic agents |
| References |
1. Walsh TJ, Clark AW, Parhad IM, et ah Neurotoxic effects of cisplatin therapy. Arch Neurol 1982;39:719-720. 2. Shingleton BJ, Bienfang DC, Albert DM, et ah Ocular toxicity associated with high-dose carmustine. Arch Ophthalmol 1982;100:1766-1772. 3. Rubin P, Hulette C, Khawley JA, et ah Ocular toxicity following high dose chemotherapy and autologous transplant. Bone Marrow Transplantation 1996;18:253-256. 4. Khawley J A, Rubin P, Petros W, et al Retinopathy and optic neuropathy in bone marrow transplantation for breast cancer. Ophthalmology 1996;103:87-95. 5. Arnold AC: Optic neuropathy and retinopathy after bone marrow transplantation. Neuro-OphthaImology 1998;20 (Suppl):9. |
| Language |
eng |
| Format |
application/pdf |
| Relation is Part of |
Case presented at the NANOS 1999 Walsh Session, February 6-7. |
| Collection |
Neuro-ophthalmology Virtual Education Library: NOVEL http://NOVEL.utah.edu |
| Publisher |
Spencer S. Eccles Health Sciences Library, University of Utah |
| Holding Institution |
North American Neuro-Ophthalmology Association. NANOS Executive Office 5841 Cedar Lake Road, Suite 204, Minneapolis, MN 55416 |
| Rights Management |
Copyright 2008. For further information regarding the rights to this collection, please visit: https://NOVEL.utah.edu/about/copyright |
| ARK |
ark:/87278/s68k7cv8 |
| Contributor Primary |
Arnold, Anthony C. |
| Contributor Secondary |
Wang, Matthew Y.; Vinters, Harry V.; Hepler, Robert S.; Glasgow, Ben J. |
| Setname |
ehsl_novel_fbw |
| ID |
178103 |
| Reference URL |
https://collections.lib.utah.edu/ark:/87278/s68k7cv8 |
