Selective inhibition of central sympathetic neurons by morphine and its reversal by naloxone.

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Title Selective inhibition of central sympathetic neurons by morphine and its reversal by naloxone.
Publication Type dissertation
School or College College of Pharmacy
Department Pharmacology & Toxicology
Author McCloskey, Kevin Lee.
Date 1976-08
Description Recent investigations clarifying the monoaminergic influences on sympathetic preganglionic neurons in the cat have allowed a direct assessment of the effects of narcotic analgesics and antagonists on central transmission. Intravenous morphine, methadone, meperidine or codeine produced an immediate and sustained depression of discharges evoked from these spinal sympathetic neurons. The potency rations for production of similar degrees of depression by these four agents compared favorably to the potency ratios reported for equianalgesic doses. The depression appeared to be specific in that it was rapidly reversed by very low doses of naloxone or nalorphine and that a non-analgesic stereoisomer related to these drugs produced qualitatively different effects on the sympathetic preganglionic neurons. The depression of these neurons offers an adequate and sufficient mechanism to account for the centrally mediated vasodepressor effect produced by morphine and other narcotic analgesics. The pharmacological characterization of the morphine and naloxone actions strongly suggests that morphine functions as a 5-HT agonist in this system, while naloxone can both block 5-HT receptors and also stimulate these spinal neurons. The significance of these findings relative to other acute and chronic effects of the narcotic analgesics are discussed.
Type Text
Publisher University of Utah
Subject Neurons; Drug Effects
Subject MESH Naloxone; Morphine
Dissertation Institution University of Utah
Dissertation Name PhD
Language eng
Relation is Version of Digital reproduction of "Selective inhibition of central sympathetic neurons by morphine and its reversal by naloxone." Spencer S. Eccles Health Sciences Library. Print version of "Selective inhibition of central sympathetic neurons by morphine and its reversal by naloxone." available at J. Willard Marriott Library Special Collection. QP 6.5 1976 M33.
Rights Management © Kevin Lee McCloskey.
Format application/pdf
Format Medium application/pdf
Identifier us-etd2,171
Source Original: University of Utah Spencer S. Eccles Health Sciences Library (no longer available).
ARK ark:/87278/s60s03z7
Setname ir_etd
ID 193090
Reference URL https://collections.lib.utah.edu/ark:/87278/s60s03z7
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