Normative Data and Conversion Equation for Spectral-Domain Optical Coherence Tomography in an International Healthy Control Cohort

Update Item Information
Title Normative Data and Conversion Equation for Spectral-Domain Optical Coherence Tomography in an International Healthy Control Cohort
Creator Rachel Kenney; Mengling Liu; Lisena Hasanaj; Binu Joseph; Abdullah A. Al-Hassan; Lisanne Balk; Raed Behbehani; Alexander U. Brandt; Peter A. Calabresi; Elliot M. Frohman; Teresa Frohman; Joachim Havla; Bernhard Hemmer; Hong Jiang; Benjamin Knier; Thomas Korn; Letizia Leocani; Elena H. Martínez-Lapiscina; Athina Papadopoulou; Friedemann Paul; Axel Petzold; Marco Pisa; Pablo Villoslada; Hanna Zimmermann; Hiroshi Ishikawa; Joel S. Schuman; Gadi Wollstein; Yu Chen; Shiv Saidha; Lorna E. Thorpe; Steven L Galetta; Laura J. Balcer; IMSVISUAL Consortium
Affiliation Departments of Neurology (RK, LH, BJ, SLG, LJB) and Population Health (RK, ML, YC, LET, LJB), New York University Grossman School of Medicine, New York, New York; Al-Bahar Ophthalmology Center (AAA-H, RB), Ibn Sina Hospital, Kuwait City, Kuwait; Centre for Research on Sports in Society (LB), Mulier Institute, Utrecht, Netherlands; Experimental and Clinical Research Center (AUB, AP, FP, HZ), Max Delbrueck Center for Molecular Medicine and Charité-Universitätsmedizin Berlin, Berlin, Germany; Department of Neurology (AUB), University of California, Irvine, California; Department of Neurology (PAC, SS), Johns Hopkins University, Baltimore, Maryland; Laboratory of Neuroimmunology (EMF, TF), Stanford University School of Medicine, Palo Alto, California; Institute of Clinical Neuroimmunology (JH), LMU Hospital, Ludwig Maximilians Universität München, Munich, Germany; Data Integration for Future Medicine consortium (DIFUTURE) (JH), Ludwig-Maximilians University, Munich, Germany; Department of Neurology (BH, BK, TK), Klinikum rechts der Isar, School of Medicine, Technical University of Munich, Munich, Germany; Munich Cluster for Systems Neurology (SyNergy) (BH, TK), Munich, Germany; Department of Neurology (HJ), Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, Florida; Vita-Salute University & Hospital San Raffaele (LL, MP), Milano, Italy; Center of Neuroimmunology and Department of Neurology (EHM-L, PV), Hospital Clinic of Barcelona, Institut d'Investigacions Biomèdiques August Pi Sunyer (IDIBAPS), University of Barcelona, Barcelona, Spain; Neurologic Clinic and Policlinic (AP), MS Center and Research Center for Clinical Neuroimmunology and Neuroscience (RCN2NB) Basel, University Hospital Basel and University of Basel, Basel, Switzerland; NeuroCure Clinical Research Center (FP, HZ), Charité-Universitätsmedizin Berlin, Berlin, Germany; Moorfields Eye Hospital (AP), London, United Kingdom ; The National Hospital for Neurology and Neurosurgery (AP), Queen Square, UCL Institute of Neurology, London, United Kingdom; Dutch Neuro-Ophthalmology Expertise Centre (AP), Amsterdam UMC, Amsterdam, the Netherlands; Oregon Health and Science University (HI), Portland, Oregon; Department of Ophthalmology (JSS, GW, SLG, LJB), New York University Grossman School of Medicine, New York, New York; Departments of Biomedical Engineering and Electrical and Computer Engineering (JSS), Tandon School of Engineering, New York University, Brooklyn, New York; Center for Neural Science (JSS), NYU, New York, New York; and Neuroscience Institute (JSS), NYU Langone Health, New York, New York
Abstract Spectral-domain (SD-) optical coherence tomography (OCT) can reliably measure axonal (peripapillary retinal nerve fiber layer [pRNFL]) and neuronal (macular ganglion cell + inner plexiform layer [GCIPL]) thinning in the retina. Measurements from 2 commonly used SD-OCT devices are often pooled together in multiple sclerosis (MS) studies and clinical trials despite software and segmentation algorithm differences; however, individual pRNFL and GCIPL thickness measurements are not interchangeable between devices. In some circumstances, such as in the absence of a consistent OCT segmentation algorithm across platforms, a conversion equation to transform measurements between devices may be useful to facilitate pooling of data. The availability of normative data for SD-OCT measurements is limited by the lack of a large representative world-wide sample across various ages and ethnicities. Larger international studies that evaluate the effects of age, sex, and race/ethnicity on SD-OCT measurements in healthy control participants are needed to provide normative values that reflect these demographic subgroups to provide comparisons to MS retinal degeneration.
Subject Adolescent; Cross-Sectional Studies; Multiple Sclerosis; Nerve Fibers; Retinal Ganglion Cells; Tomography; OCT; Young Adult
OCR Text Show
Date 2022-12
Date Digital 2022-12
References 1. Nolan RC, Akhand O, Rizzo JR, Galetta SL, Balcer LJ. Evolution of Visual Outcomes in Clinical Trials for Multiple Sclerosis Disease-Modifying Therapies. Journal of neuro-ophthalmology : the official journal of the North American Neuro-Ophthalmology Society. 2018;38(2):202-9. - PMC - PubMed. 2. Bhargava P, Lang A, Al-Louzi O, Carass A, Prince J, Calabresi PA, et al. Applying an Open-Source Segmentation Algorithm to Different OCT Devices in Multiple Sclerosis Patients and Healthy Controls: Implications for Clinical Trials. Multiple sclerosis international. 2015;2015:136295. - PMC - PubMed. 3. Pierro L, Gagliardi M, Iuliano L, Ambrosi A, Bandello F. Retinal Nerve Fiber Layer Thickness Reproducibility Using Seven Different OCT Instruments. Investigative Opthalmology & Visual Science. 2012;53(9). - PubMed. 4. Miller M, Zemon V, Nolan-Kenney R, Balcer LJ, Goff DC, Worthington M, et al. Optical coherence tomography of the retina in schizophrenia: Inter-device agreement and relations with perceptual function. Schizophrenia Research. 2020. - PubMed. 5. Watson GM, Keltner JL, Chin EK, Harvey D, Nguyen A, Park SS. Comparison of retinal nerve fiber layer and central macular thickness measurements among five different optical coherence tomography instruments in patients with multiple sclerosis and optic neuritis. Journal of neuro-ophthalmology : the official journal of the North American Neuro-Ophthalmology Society. 2011;31(2):110-6. - PubMed.
Language eng
Format application/pdf
Type Text
Publication Type Journal Article
Source Journal of Neuro-Ophthalmology, December 2022, Volume 42, Issue 4
Collection Neuro-Ophthalmology Virtual Education Library: Journal of Neuro-Ophthalmology Archives: https://novel.utah.edu/jno/
Publisher Lippincott, Williams & Wilkins
Holding Institution Spencer S. Eccles Health Sciences Library, University of Utah
Rights Management © North American Neuro-Ophthalmology Society
ARK ark:/87278/s6v54tkw
Setname ehsl_novel_jno
ID 2392980
Reference URL https://collections.lib.utah.edu/ark:/87278/s6v54tkw
Back to Search Results