Relationship Between Age, Gender, and Race in Patients Presenting With Myasthenia Gravis With Only Ocular Manifestations

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Title Relationship Between Age, Gender, and Race in Patients Presenting With Myasthenia Gravis With Only Ocular Manifestations
Creator Jason H. Peragallo, MD; Elena Bitrian, MD; Mark J. Kupersmith, MD; Fritz Zimprich, MD, PhD; Thomas J. Whittaker, MD, JD; Michael S. Lee, MD; Beau B. Bruce, MD, PhD
Affiliation Departments of Ophthalmology (JHP, BBB), Pediatrics (JHP), and Neurology (BBB), Emory University, Atlanta, Georgia; Department of Ophthalmology and Visual Neurosciences (EB, MSL), University of Minnesota, Minneapolis, Minnesota; New York Eye and Ear Infirmary and INN at Roosevelt Hospital (MJK), New York, New York; Department of Neuro-ophthalmology (MJK), New York Eye and Ear Infirmary of Mount Sinai, New York, New York; Department of Neurology (FZ), Medical University of Vienna, Vienna, Austria; Department of Ophthalmology (TJW), University of Kansas Medical Center, Kansas City, Kansas; and Department of Epidemiology (B.B.B.), Rollins School of Public Health and Laney Graduate School, Emory University, Atlanta, Georgia
Abstract Myasthenia gravis is an autoimmune disease of the neuromuscular junction, commonly affecting the ocular muscles. Cigarette smoking has been shown to influence many autoimmune diseases, including multiple sclerosis and rheumatoid arthritis, but its effect on myasthenia gravis has not been well studied. We sought to determine whether cigarette smoking influenced disease-related symptoms in ocular myasthenia gravis (OMG).; ; We performed a prospective, clinic-based cross-sectional study in a single academic neuro-ophthalmology practice. All patients diagnosed with OMG between November 2006 and April 2014 were included. A prospective telephone survey was administered to determine smoking status and myasthenia gravis-related symptom severity. The main outcome measure was the myasthenia gravis-specific activities of daily living (MG-ADL) score, a well-validated marker of symptoms and quality of life in myasthenia gravis.; ; Forty-four patients were included in the analysis. Comparison of MG-ADL ocular subscores between current smokers (3.4 ± 2.6), former smokers (1.8 ± 2.1), and never smokers (1.1 ± 1.5) revealed a statistically significant relationship (P = 0.031) where current smokers had the highest MG-ADL ocular subscores and never smokers the lowest. Comparison of MG-ADL total scores revealed the same relationship (current 5.6 ± 4.5, former 2.9 ± 3.1, never 1.4 ± 2.5, P = 0.003). There were borderline significant correlations of pack years with MG-ADL ocular subscore (r = 0.27, P = 0.074) and MG-ADL total score (r = 0.30, P = 0.051).; ; Our findings indicate an association between cigarette smoking and symptom severity in OMG. This association suggests that smoking cessation in OMG patients may lead to improved symptom-related quality of life.
Subject Adult; Age Distribution; Older people; Disease Progression; Ethnic Groups; Eye Diseases; Female; Humans; Incidence; Male; Middle Older people; Myasthenia Gravis; Oculomotor Muscles; Retrospective Studies; Sex Distribution; United States
OCR Text Show
Date 2016-03
Language eng
Format application/pdf
Type Text
Publication Type Journal Article
Collection Neuro-Ophthalmology Virtual Education Library: Journal of Neuro-Ophthalmology Archives: https://novel.utah.edu/jno/
Publisher Lippincott, Williams & Wilkins
Holding Institution Spencer S. Eccles Health Sciences Library, University of Utah
Rights Management © North American Neuro-Ophthalmology Society
ARK ark:/87278/s6bg6hhn
Setname ehsl_novel_jno
ID 1276450
Reference URL https://collections.lib.utah.edu/ark:/87278/s6bg6hhn
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