An Exploratory Study to Investigate the Utility of Clinical Screening for Neurodegenerative Disease in Age-Related Eye Disease Research

Update Item Information
Title An Exploratory Study to Investigate the Utility of Clinical Screening for Neurodegenerative Disease in Age-Related Eye Disease Research
Creator Victoria S. Pelak; Yosbelkys Martin Paez; Jennifer L. Patnaik; Samantha K. Holden; Prem S. Subramanian; Marc T. Mathias; Naresh Mandava; Anne M. Lynch
Affiliation Departments of Neurology (VSP, YMP, SKH, PSS), Ophthalmology (VSP, YMP, JLP, PSS, MTM, NM, AML), and Neurosurgery (PSS), University of Colorado School of Medicine, Aurora, Colorado; and Department of Surgery (PSS), Division of Ophthalmology, Uniformed Services University of the Health Sciences, Bethesda, Maryland
Abstract Background: Unrecognized neurodegenerative diseases (NDD) in age-related eye disease research studies have the potential to confound vision-specific quality of life and retinal optical coherence tomography (OCT) outcome measures. The aim of this exploratory study was to investigate relationships between NDD screening tools and visual outcome measures in a small cohort of controls from the Colorado Age-Related Macular Degeneration Registry (CO-AMD), to consider the utility of future studies. Methods: Twenty-nine controls from the CO-AMD were screened using the Montreal Cognitive Assessment (MoCA), a Colorado Parkinsonian Checklist, and the Lewy Body Composite Risk Score. Univariate and multivariable linear regression modeling was used to assess associations between screening tools and the National Eye Institute Visual Function Questionnaire-25 (VFQ-25) and macular OCT outcome measures, and t tests were used to evaluate outcome measure differences between those with normal vs abnormal MoCA scores. Results: One patient withdrew. The average age was 72.8 years, and 68% were female patients. Ten participants (36%) had abnormal MoCA scores, and their VFQ-25 scores were only 1 point less and not statistically different than those with normal MoCA scores. Macular OCT volumes and thicknesses for retinal nerve fiber layer (RNFL) and retinal ganglion cell layer were consistently and moderately lower for those with abnormal MoCA scores, and a positive association between MoCA and macular RNFL volume was observed, although differences and regression were not significant. Parkinson screening tests were abnormal for only 4 participants and were not associated with OCT or VFQ-25 measures by regression modeling. Conclusions: Given the degree and direction of observed differences, further investigation is warranted regarding the relationship between cognitive screening tools and macular OCT measures in age-related eye disease research, but future investigations regarding the relationship between NDD screening tools and VFQ-25 seem unwarranted.
Subject Macular Degeneration; Neurodegenerative Diseases; Quality of Life; Retinal Ganglion Cells; Optical Coherence Tomography; Visual Acuity
OCR Text Show
Date 2022-09
Date Digital 2022-09
Language eng
Format application/pdf
Type Text
Publication Type Journal Article
Source Journal of Neuro-Ophthalmology, September 2022, Volume 42, Issue 3
Collection Neuro-Ophthalmology Virtual Education Library: Journal of Neuro-Ophthalmology Archives: https://novel.utah.edu/jno/
Publisher Lippincott, Williams & Wilkins
Holding Institution Spencer S. Eccles Health Sciences Library, University of Utah
Rights Management © North American Neuro-Ophthalmology Society
ARK ark:/87278/s6pw4kd9
Setname ehsl_novel_jno
ID 2344179
Reference URL https://collections.lib.utah.edu/ark:/87278/s6pw4kd9
Back to Search Results