Nafcillin-induced platelet dysfunction

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Title Nafcillin-induced platelet dysfunction
Publication Type dissertation
School or College College of Pharmacy
Department Pharmacotherapy
Author Alexander, Jr., Donald Page
Date 1981-05
Description Many drugs interfere with the normal hemostatic function of platelets. The largest number of reported cases of antibiotic-induced hemostatic defects is associated with carbenicillin and penicillin G. These hemostatic defects are identified primarily as platelet dysfunction with some cases resulting in clinical bleeding. Ampicillin, methicillin, oxacillin, cloxacillin, ticarcillin, cephalothin, and cefazolin show similar effects when these drugs are given to animals or humans prior to blood sampling for in vitro aggregation studies. This same dysfunction is thought to occur when normal platelet-rich plasma is spiked with these drugs prior to aggregation studies. The exact mechanism the effect on platelets is unknown. The objectives of this study were; 1.) To evaluate the effect of nafcillin on platelet aggregation and 2.) To investigate the effect of increasing concentrations of nafcillin on the aggregation response.
Type Text
Publisher University of Utah
Subject MESH Research Design; Platelet Aggregation; Platelet Activation; Collagen; Anti-Bacterial Agents; Nafcillin; Blood Platelet Disorders; Drug-Related Side Effects and Adverse Reactions; Hemostatic Disorders; Adenosine Diphosphate; Epinephrine
Dissertation Institution University of Utah
Dissertation Name Doctor of Pharmacy
Language eng
Relation is Version of Digital reproduction of Nafcillin-induced platelet dysfunction
Rights Management Copyright © Donald Page Alexander, Jr. 1981
Format application/pdf
Format Medium application/pdf
ARK ark:/87278/s6697jd4
Setname ir_etd
ID 195973
Reference URL https://collections.lib.utah.edu/ark:/87278/s6697jd4
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