Mechanism of the emetic action of nicotine and lobeline

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Title Mechanism of the emetic action of nicotine and lobeline
Publication Type thesis
School or College College of Pharmacy
Department Pharmacology & Toxicology
Author Laffan, Robert Joseph
Date 1957-02
Description The emetic action of nicotine and lobeline was studied in cats and dogs. The minimal uniformly effective emetic doses were found to be 1.5 mg/kg I.M. nicotine bitartrate and 0.5 mg/kg I.M. lobeline sulfate. In terms of the alkaloid base, the dose-response relationship coincided, for practical purposes, at all dose levels studies. Sixty-six cats and ten dogs were used to establish the locus of the emetic action of the alkaloids. It was found, in cats, the agents stimulated two different sites of action, namely, a peripheral locus ( or loci) as well as the CT-zone. Therefore, in order to eliminate vomiting response to nicotine and lobeline in cats, it was necessary to combine the following procedures: spinal visceral deafferentation, vagotomy, and CT-zone ablation. The combination of these lesions was accomplished either by peripheral nerve sections in combination with CT-zone ablation or by a broad medullary lesion with destroyed both the CT-zone and incoming visceral afferents. The dogs, CT-zone ablation alone sufficed to protect animals against the emetic effect of nicotine and lobeline. The implication of these results in discussed in light of investigations of species variations previously reported in this field. Anti-emetic drug studies were also included in the present investigation. Tetraethylammonium (TEA) was effective in preventing emesis in response to nicotine in both cats and dogs, but it was effective only against lobeline in cats. Hexamethonium (C6) protected both species against uniformly effective emetic doses of nicotine and lobeline. Neither atropine nor chlorpromazine was found significantly to protect animal of either species against the emetic action of nicotine and lobeline.
Type Text
Publisher University of Utah
Subject Emetics; Vomiting; Nicotine; Lobeline
Subject MESH Vomiting; Lobeline; Nicotine; Cats; Dogs
Dissertation Institution University of Utah
Dissertation Name MS
Language eng
Relation is Version of Digital reproduction of "Mechanism of the emetic action of nicotine and lobeline". Spencer S. Eccles Health Sciences Library. Print version of "Mechanism of the emetic action of nicotine and lobeline". available at J. Willard Marriott Library Special Collection. RM31.5 1957 .L34.
Rights Management © Robert Joseph Laffen.
Format application/pdf
Format Medium application/pdf
Format Extent 1,787,201 bytes
Identifier undthes,3785
Source Original: University of Utah Spencer S. Eccles Health Sciences Library (no longer available)
Master File Extent 1,787,242 bytes
ARK ark:/87278/s6cz38zk
Setname ir_etd
ID 190898
Reference URL https://collections.lib.utah.edu/ark:/87278/s6cz38zk
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