Should Aquaporin-4 Antibody Test Be Performed in all Patients With Isolated Optic Neuritis?

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Title Should Aquaporin-4 Antibody Test Be Performed in all Patients With Isolated Optic Neuritis?
Creator Rosalynn G. Siantar; Farah N. I. Ibrahim; Hla M. Htoon; Sharon L. C. Tow; Kong Yong Goh; Jing Liang Loo; Su Ann Lim; Dan Milea; Melissa C. H. Tien; Zhiyong Chen; Tianrong Yeo; Josiah Y. H. Chai; Shweta Singhal; Chee Fang Chin; Kevin Tan
Affiliation National Healthcare Group Eye Institute (RGS, SAL, MT, CFC), Tan Tock Seng Hospital, Singapore ; Department of Neuro-Ophthalmology (FI, ST, JLL, DM, SS), Singapore National Eye Centre, Singapore ; Data Science Unit (HMH), Singapore Eye Research Institute, Singapore ; Mount Elizabeth Novena Hospital (KYG), Singapore ; Department of Neurology (ZC, TY, JC, KT), National Neuroscience Institute, Singapore ; and Duke-NUS Medical School (KT), Singapore
Abstract Optic neuritis (ON) may be the initial manifestation of neuromyelitis optica spectrum disorder (NMOSD). Aquaporin-4 antibody (AQP4 Ab) is used to diagnose NMOSD. This has implications on prognosis and is important for optimal management. We aim to evaluate if clinical features can distinguish AQP4 Ab seropositive and seronegative ON patients.
Subject Aquaporin 4; Autoantibodies; Neuromyelitis Optica; Optic Neuritis; Visual Acuity; Young Adult
OCR Text Show
Date 2022-12
Date Digital 2022-12
References 1. Bennett JL. Optic neuritis. Continuum (Minneap Minn). 2019;25:1236-1264. 2. Hor JY, Asgari N, Nakashima I, Broadley SA, Leite MI, Kissani N, Jacob A, Marignier R, Weinshenker BG, Paul F, Pittock SJ, Palace J, Wingerchuk DM, Behne JM, Yeaman MR, Fujihara K. Epidemiology of neuromyelitis optica spectrum disorder and its prevalence and incidence worldwide. Front Neurol. 2020;11:501. 3. Chen JJ, Pittock SJ, Flanagan EP, Lennon VA, Bhatti MT. Optic neuritis in the era of biomarkers. Surv Ophthalmol. 2020;65:12-17. 4. Jarius S, Frederikson J, Waters P, Paul F, Akman-Demir G, Marignier R, Franciotta D, Ruprecht K, Kuenz B, Rommer P, Kristoferitsch W, Wildemann B, Vincent A. Frequency and prognostic impact of antibodies to aquaporin-4 in patients with optic neuritis. J Neurol Sci. 2010;298:158-162. 5. Petzold A, Pittock S, Lennon V, Maggiore C, Weinshenker BG, Plant GT. Neuromyelitis optica-IgG (aquaporin-4) autoantibodies in immune mediated optic neuritis. J Neurol Neurosurg Psychiatry. 2010;81:109-111.
Language eng
Format application/pdf
Type Text
Publication Type Journal Article
Source Journal of Neuro-Ophthalmology, December 2022, Volume 42, Issue 4
Collection Neuro-Ophthalmology Virtual Education Library: Journal of Neuro-Ophthalmology Archives: https://novel.utah.edu/jno/
Publisher Lippincott, Williams & Wilkins
Holding Institution Spencer S. Eccles Health Sciences Library, University of Utah
Rights Management © North American Neuro-Ophthalmology Society
ARK ark:/87278/s64tgtmz
Setname ehsl_novel_jno
ID 2392993
Reference URL https://collections.lib.utah.edu/ark:/87278/s64tgtmz
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