Clinical Manifestations of Myasthenia Gravis

Myasthenia Gravis (MG) is an autoimmune disorder of neuromuscular transmission in which acetylcholine receptor antibodies attack the postsynaptic membrane of the neuromuscular junction. Reduction in the number of acetylcholine receptors and structural damage to the membrane impair synaptic transmission from motor axons to muscle and result in the weakness and fatigability that characterize this disease. The muscle weakness worsens with exertion or sustained activity. MG can weaken any striated voluntary muscles, and may produce life-threatening symptoms such as dysphagia and respiratory failure. Fortunately therapeutic advances have increased patients' survival and life expectancy.