Retropective, exploratory analysis of predictive and structural variables related to metabolic energy expenditure in traumatic brain injury

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Title Retropective, exploratory analysis of predictive and structural variables related to metabolic energy expenditure in traumatic brain injury
Publication Type dissertation
School or College College of Nursing
Department Nursing
Author Sunderland, Peter M.
Date 1990-08
Description Traumatic brain injury (TBI) produces severe derangements in metabolic and physiologic function with significant ramifications for determining nutritional therapy. The ability to understand the nature of current metabolic indicators is essential to improving the outcome from TBI. This study is a retrospective exploratory analysis of the predictive value and structural nature of current variables related to metabolic energy expenditure. The variables evaluated in this study address pertinent processes of nutritional metabolism including injury classification, indices of metabolic expenditure advocated in the literature, concurrent treatments in TBI, clinical vital signs, neurological responses, glucose synthesis, protein synthesis and nitrogen excretion, and immune responses. Analysis of the data included descriptive, correlational, predictive (regression), and factor modeling. Significant results include the lack of precision of current methods of restimating caloric expenditure in this population. Further, only 31% of this sample energy expenditure values as measured by indirect calorimetry were in the normal metabolic range as predicted by the Harris-Benedict Equation. Cost effectiveness of indirect calorimetry was further analyzed and found to be less expensive than alternative methods. Factor analysis of the metabolic variables provided a unique structure for conceptualizing the dimensions the metabolic variables represent. Patients with TBI display unique metabolic patterns with significant implications for monitoring and supplementation. An integrated management model for nutrition in TBI is proposed with recommendations for timing of initiation, caloric supplementation, and delivery methods. Research implications are discussed
Type Text
Publisher University of Utah
Subject Complications
Subject MESH Brain Injuries; Metabolic Diseases; Nutrition
Dissertation Institution University of Utah
Dissertation Name PhD
Language eng
Relation is Version of Digital reproduction of A retropective, exploratory analysis of predictive and structural variables related to metabolic energy expenditure in traumatic brain injury" Spencer S. Eccles Health Sciences Library.
Rights Management © Peter M. Sunderland.
Format application/pdf
Format Medium application/pdf
Format Extent 2,799,112 bytes
Identifier undthes,4031
Source Original: University of Utah Spencer S. Eccles Health Sciences Library (no longer available)
Master File Extent 2,799,158 bytes
ARK ark:/87278/s6bk1f5g
Setname ir_etd
ID 191177
Reference URL https://collections.lib.utah.edu/ark:/87278/s6bk1f5g
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