Shortened Pattern Electroretinogram Latency and Impaired Autoregulatory Dynamics to Steady-State Stimuli in Patients With Multiple Sclerosis

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Title Shortened Pattern Electroretinogram Latency and Impaired Autoregulatory Dynamics to Steady-State Stimuli in Patients With Multiple Sclerosis
Creator Hong Jiang; Giovana R. Gameiro; Huiling Hu; Pedro F. Monsalve; Chuanchui Dong; Jeffrey Hernandez; Silvia R. Delgado; Vittorio D. Porciatti; Jianhua Wang
Affiliation Department of Ophthalmology (HJ, GRG, HH, PFM, VDP, JW), Bascom Palmer Eye Institute, University of Miami, Miller School of Medicine, Miami, Florida; Department of Neurology (HJ, CD, JH, SRD), University of Miami, Miller School of Medicine, Miami, Florida; and Department of Ophthalmology (HH), Shenzhen Key Laboratory of Ophthalmology, Shenzhen Eye Hospital, Jinan University, Shenzhen, China
Abstract Background: The steady-state pattern electroretinogram (PERG) is a sensitive measure of retinal ganglion cell (RGC) function that includes within-test progressive changes-adaptation-reflecting RGC autoregulatory dynamics. Comprehensive PERG assessment in patients with multiple sclerosis (MS) (with or without optic neuritis [ON]) may provide unique information about RGC dysfunction and its progression, as well as a comparison between functional loss and structural loss as measured by optical coherence tomography (OCT). The goal of this project was to measure steady-state PERG components and their associations with intraretinal layer thicknesses in MS.
Subject Axons; Electroretinography; Homeostasis; Multiple Sclerosis; Optic Neuritis; Visual Pattern Recognition; Retinal Ganglion Cells; Optical Coherence Tomography; Visual Acuity
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Date 2021-03
Language eng
Format application/pdf
Type Text
Publication Type Journal Article
Source Journal of Neuro-Ophthalmology, March 2021, Volume 41, Issue 1
Collection Neuro-Ophthalmology Virtual Education Library: Journal of Neuro-Ophthalmology Archives: https://novel.utah.edu/jno/
Publisher Lippincott, Williams & Wilkins
Holding Institution Spencer S. Eccles Health Sciences Library, University of Utah
Rights Management © North American Neuro-Ophthalmology Society
ARK ark:/87278/s6qa98m3
Setname ehsl_novel_jno
ID 1765165
Reference URL https://collections.lib.utah.edu/ark:/87278/s6qa98m3
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