Treatment Failures in the Idiopathic Intracranial Hypertension Treatment Trial

The purpose of the Idiopathic Intracranial Hypertension Treatment Trial (IIHTT) was to determine whether acetazolamide is beneficial in improving vision when added to a low sodium, weight reduction diet in idiopathic intracranial hypertension (IIH) patients with mild visual loss. During the first six months of the intervention phase, six subjects on placebo and one subject on acetazolamide met criteria for treatment failure. Male patients, those with high grade papilledema and those with decreased visual acuity at baseline were more likely to experience treatment failure.