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1 Visual Cortex and Weird Phenomena (Anton's to Riddoch's)Alfredo A. Sadun, MD, PhD, Flora L. Thornton Chair, Professor of Ophthalmology and Neurological Surgery, Keck School of Medicine at USCPresenting Symptom: Alexia, Pure; Agraphia; Prosopagnosia; Palinopsia; Geschwind's Syndrome; Apraxia. Anatomy: Visual cortex; Optic nerve. Disease/Diagnosis: Aphasia; Hallucinations, Visual; Anton's Syndrome; Visual Agnosia; Blindness, Cortical; Cortical paralysis of fixation syndrome; Alzheimer's S...Alexia, Pure; Agraphia; Prosopagnosia; Palinopsia; Geschwind's Syndrome; Apraxia; Aphasia; Hallucinations, Visual; Anton's Syndrome; Visual Agnosia; Blindness, Cortical; Cortical Paralysis of Fixation Syndrome; Alzheimer's Syndrome; Visual Cortex; Optic Nerve; Higher Cortical Dysfunction; Specializ...
2 AIDS: neuro-ophthalmologic manifestationsAlfredo A. Sadun, MD, PhD, Flora L. Thornton Chair, Professor of Ophthalmology and Neurological Surgery, Keck School of Medicine at USCDiscusses various neuro-opthalmological complications to which AIDS patients are prone, and results of experimental testing on rabbits using Pentoxifylline. Anatomy: Optic nerve; Axons; Optic disk; Astrocytes; Macrophages. Pathology: Slides showing astrocytes, macrophages, cytokine staining. Disease...Optic nerve; Axons; Optic disk; Astrocytes; Macrophages; Infarction; Pneumocystis carinii; Acquired immunodeficiency syndrome; Cytomegalovirus retinitis; Retinal necrosis syndrome, Acute; Cryptococcus; Meningitis; Leukoencephalopathy, Progressive multifocal; Papilledema; AIDS dementia complex; Cellu...
3 Acute Retrobulbar Optical NeuropathyAlfredo A. Sadun, MD, PhD, Flora L. Thornton Chair, Professor of Ophthalmology and Neurological Surgery, Keck School of Medicine at USCPPT covering acute retrobulbar optic neuropathy, including ischemic, inflammatory, anterior ischemic optic neuropathy (AION) and non-arteritic anterior ischemic optic neuropathy (NAION); includes brainscan images for optic neuritis and multiple sclerosis; optic disk with LHON and PION. Anatomy: Opt...Optic Neuropathy, Ischemic; Giant Cell Arteritis; Edema; Multiple sclerosis; Optic Atrophy, Hereditary, Leber; Ischemia; Hypotension; Edema; Optic Neuritis; Optic Nerve; Interferon-Beta-1a; Diseases of the Optic Nerve
4 A Neuro-Ophthalmologist's View of RGC Apoptosis and NeuroprotectionAlfredo A. Sadun, MD, PhD, Flora L. Thornton Chair, Professor of Ophthalmology and Neurological Surgery, Keck School of Medicine at USCSlide presentation with several microscopic images demonstrating cell death, LHON, AIDS. Anatomy: Optic nerve; Retina; Retinal ganglion cells; Phosphopyruvate Hydratase; Reactive oxygen species. Disease/Diagnosis: Optic Atrophy, Hereditary, Leber; Acquired Immunodeficiency Syndrome; Glaucoma. Presen...Optic Nerve; Retina; Retinal Ganglion Cells; Phosphopyruvate Hydratase; Apoptosis; Cell Death; Blindness; Ischemia; Retinal Detachment; Optic Atrophy, Hereditary, Leber; Acquired Immunodeficiency Syndrome; Glaucoma
5 Cuban Epidemic of Optic Neuopathy: Even Zealots Must Eat, or, Conversations with CastroAlfredo A. Sadun, MD, PhD, Flora L. Thornton Chair, Professor of Ophthalmology and Neurological Surgery, Keck School of Medicine at USCA team of neuro-opthalmologists visits Cuba in 1993 and 1994, and attempts to treat patients with vision disorders. Anatomy: Optic nerve; Structure of cribriform plate. Disease/Diagnosis: Optic nerve diseases; Blindness; Ambliopia; Alcoholic neuropathy. Treatment: Folate. Presenting Symptom: Ataxia;...Cuba; Castro, Fidel, 1926- ; Folate; Optic nerve; Structure of cribriform plate; Optic nerve diseases; Alcoholic neuropathy; Blindness; Ambliopia; Ataxia; Paresthesia; Hyporeflexia
6 Anatomy and Physiology of the Optic NerveAlfredo A. Sadun, MD, PhD, Flora L. Thornton Chair, Professor of Ophthalmology and Neurological Surgery, Keck School of Medicine at USCLecture covering the anatomy and physiology of the optic nerve. Covers the retina and anterior visual pathways. Several slides show microscopic images of optic nerve damage. Anatomy: Optic nerve; Retina; Retinal ganglion cells; Cytokines. Disease/Diagnosis: Glaucoma.Optic Nerve; Retina; Retinal Ganglion Cells; Cytokines; Apoptosis; Cell Death; Glaucoma; Anatomy of the Optic Nerve; AVP Optic Nerve
7 An Epidemic of Blindness in Cuba: Lessons on Nutrition and MitochondriaAlfredo A. Sadun, MD, PhD, Flora L. Thornton Chair, Professor of Ophthalmology and Neurological Surgery, Keck School of Medicine at USCPresented at Stanford in April 2007, recapping the 1990s expedition to Cuba to investigate causes of blindness epidemic. Anatomy: Optic nerve. Disease/Diagnosis: Optic nerve diseases; Alcoholic neuropathy. Treatment: Folate. Presenting Symptom: Ambliopia; Ataxia; Paresthesia; Hyporeflexia.Cuba; Castro, Fidel, 1926-; Folate; Optic Nerve; Optic Nerve Diseases; Alcoholic Neuropathy; Blindness; Ambliopia; Ataxia; Paresthesia; Hyporeflexia
8 Apoptosis in LHON: an ROS explanationAlfredo A. Sadun, MD, PhD, Flora L. Thornton Chair, Professor of Ophthalmology and Neurological Surgery, Keck School of Medicine at USCA slide presentation describing apoptosis in LHON; includes several images of optic nerve and optic disk. Anatomy: Optic nerve; Optic disk; Retinal ganglion cells; Reactive oxygen species. Disease/Diagnosis: Optic Atrophy, Hereditary, Leber.Optic Atrophy, Hereditary, Leber; Brazil; Optic nerve; Optic disk; Retinal ganglion cells; Reactive oxygen species; Apoptosis; Cell death; ROS1 protein, human
9 Compressive Optic Neuropathies PotpourriAlfredo A. Sadun, MD, PhD, Flora L. Thornton Chair, Professor of Ophthalmology and Neurological Surgery, Keck School of Medicine at USCAn overview of compressive optic neuropathies, including symptoms, varieties, testing, and treatments; slide presentation includes several neuroimaging scans. Anatomy: Optic nerve. Disease/Diagnosis: Compression of optic nerve. Treatment: MifepristoneOptic Nerve; Compression of Optic Nerve; Mifepristone
10 Anatomy and Physiology of Vision: The Visual PathwaysAlfredo A. Sadun, MD, PhD, Flora L. Thornton Chair, Professor of Ophthalmology and Neurological Surgery, Keck School of Medicine at USCIntroduction to neuro-ophthalmology, covering the optic nerve, the afferent visual system (eye to brain), the pupil (Afferent-Efferent Reflex), and the efferent visual system (eye movements). Anatomy: Optic nerve; Optic disc; Retina; Retinal ganglion cells; Optic chiasm; Visual cortex. Disease/Diagn...Optic Nerve; Optic Disc; Retina; Retinal Ganglion Cells; Optic Chiasm; Visual Cortex; Pituitary Adenoma; Optic Atrophy; Anatomy of Visual Pathways; Afferent Visual Pathways
11 Beyond the Margulis Hypothesis: The Time Bomb Within UsAlfredo A. Sadun, MD, PhD, Flora L. Thornton Chair, Professor of Ophthalmology and Neurological Surgery, Keck School of Medicine at USCPresented at 36th Annual Doheny Days, 2005. Anatomy: Optic nerve; Retina; Retinal ganglion cells; Reactive oxygen species. Disease/Diagnosis: Optic Atrophy, Hereditary, Leber.Apoptosis; Cell Death; Optic Atrophy, Hereditary, Leber; Optic Nerve; Retina; Retinal Ganglion Cells; Reactive Oxygen Species
12 Apoptosis of Retinal Ganglion CellsAlfredo A. Sadun, MD, PhD, Flora L. Thornton Chair, Professor of Ophthalmology and Neurological Surgery, Keck School of Medicine at USCPresented at a conference on neuroprotection at Sedona, Arizona, 2002; includes several microscopic images demonstrating cell death. Anatomy: Optic nerve; Retina; Retinal ganglion cells; Cytokines. Disease/Diagnosis: Glaucoma.Optic Nerve; Retina; Retinal Ganglion Cells; Cytokines; Apoptosis; Cell Death; Glaucoma
13 Cushing and OphthalmologyAlfredo A. Sadun, MD, PhD, Flora L. Thornton Chair, Professor of Ophthalmology and Neurological Surgery, Keck School of Medicine at USCFrom a lecture at Yale in 2006, reviewing the life of Harvey Cushing, the founder of neurosurgery. Anatomy: Optic chiasm; Optic nerve. Disease/Diagnosis: Pituitary adenoma; Papilledema; X-linked hydrocephalus syndrome; Optic nerve glioma; Graves ophthalmopathy; Mucocele; Pituitary apoplexy; Optic ne...Cushing, Harvey, 1869-1939; Neurosurgery; Optic chiasm; Optic nerve; Proptosis; Dplopia; Ptosis; Hemianopsia; Pituitary adenoma; Papilledema; X-linked hydrocephalus syndrome; Optic nerve glioma; Graves ophthalmopathy; Mucocele; Pituitary apoplexy; Optic nerve atrophy; Neurosurgery; Decompression, Su...
14 Distinguishing an Optic Neuropathy from a MaculopathyAlfredo A. Sadun, MD, PhD, Flora L. Thornton Chair, Professor of Ophthalmology and Neurological Surgery, Keck School of Medicine at USCPPT describing a case of optic neuropathy. Covers signs and symptoms, and various laboratory tests. Describes 10 signes of disc edema. Anatomy: Optic nerve; Retina; Retinal macula. Disease/Diagnosis: Optic nerve diseases; Retinal lesion; Macular lesion; Disorder of the optic nerve; Afferent pupillar...Optic nerve diseases; Retinal lesion; Macular lesion; Disorder of the optic nerve; Afferent pupillary defect; Edema; Optic nerve; Retina; Retinal macula; Scotoma; Optic neuritis; Hyperopia; Metamorphopsia; Diseases of the Optic Nerve
15 Distinguishing Optic Nerve vs. Retinal LesionsAlfredo A. Sadun, MD, PhD, Flora L. Thornton Chair, Professor of Ophthalmology and Neurological Surgery, Keck School of Medicine at USCPPT describing methods of distinguishing optic nerve verses retinal lesions. Describes a pateint case. Discussed signs, symtpoms and diagnostic tests. Anatomy: Optic nerve; Retina; Retinal macula. Disease/Diagnosis: Optic nerve diseases; Retinal lesion; Macular lesion; Disorder of the optic nerve; A...Optic Nerve Diseases; Retinal Lesion; Disorder of the Optic Nerve; Macular Lesion; Retinal Macula; Afferent Pupillary Defect; Scotoma; Optic Neuritis; Hyperopia; Metamorphopsia; Optic Nerve; Retina; Diseases of the Optic Nerve
16 Cuban Epidemic of Optic Neuopathy: Even Zealots Must Eat, or, Conversations with CastroAlfredo A. Sadun, MD, PhD, Flora L. Thornton Chair, Professor of Ophthalmology and Neurological Surgery, Keck School of Medicine at USCA team of neuro-opthalmologists visits Cuba in 1993 and 1994, and attempts to treat patients with vision disorders. Anatomy: Optic nerve. Disease/Diagnosis: Optic nerve diseases; Alcoholic neuropathy. Treatment: Folate. Presenting Symptom: Blindness; Ambliopia; Ataxia; Paresthesia; Hyporeflexia.Cuba; Castro, Fidel, 1926-; Folate; Optic nerve; Optic nerve diseases; Blindness; Ambliopia; Alcoholic neuropathy; Ataxia; Paresthesia; Hyporeflexia
17 Beyond the Margulis Hypothesis: the Time Bomb Within UsAlfredo A. Sadun, MD, PhD, Flora L. Thornton Chair, Professor of Ophthalmology and Neurological Surgery, Keck School of Medicine at USCPresented at Harvard, 2005; includes several images of optic disc with LHON. Anatomy: Optic nerve; Optic disk; Retinal ganglion cells; Reactive oxygen species. Disease/Diagnosis: Optic Atrophy, Hereditary, Leber. Presenting Symptom: Dyschromatopsia; Scotoma.Apoptosis; Cell Death; Optic Atrophy, Hereditary, Leber; Optic Nerve; Optic Disk; Retinal Ganglion Cells; Reactive Oxygen Species; Dyschromatopsia; Scotoma
18 Posterior Ischemic Optic NeuropathyAlfredo A. Sadun, MD, PhD, Flora L. Thornton Chair, Professor of Ophthalmology and Neurological Surgery, Keck School of Medicine at USCDiscusses opthalmic complications of surgery, with example of shock-induced Posterior Ischemic Optic Neuropathy following a hysterectomy. Presenting Symptom: Ischemia; Hypotension. Anatomy: Optic nerve. Disease/Diagnosis: Optic neuropathy, Ischemic; Hematoma; Edema.Optic Neuropathy, Ischemic; Hematoma; Edema; Ischemia; Hypotension; Optic Nerve; Posterior Ischemic Optic Neuropathy
19 Prognosis for Vision in Idiopathic Intracranial Hypertension (IIH)Alfredo A. Sadun, MD, PhD, Flora L. Thornton Chair, Professor of Ophthalmology and Neurological Surgery, Keck School of Medicine at USCTreatment options for Pseudotumor cerebri and Papilledema; includes images of optic disc with edema. Presenting Symptom: Scotoma. Anatomy: Optic disc; Optic nerve. Pathology: Microscopic view of papilledema. Disease/Diagnosis: Pseudotumor cerebri; Papilledema. Treatment: Acetazolamide; Ventriculoper...Optic Nerve; Optic Disc; Pseudotumor Cerebri; Papilledema; Scotoma; Acetazolamide; Ventriculoperitoneal Shunt; Lumbo-Peritoneal CSF Shunt; Decompression of Optic Nerve; Raised Intracranial Pressure
20 Optical Coherence Tomography (OCT) Applications in the EyeAlfredo A. Sadun, MD, PhD, Flora L. Thornton Chair, Professor of Ophthalmology and Neurological Surgery, Keck School of Medicine at USCOptical Coherence Tomography is a technique for non-invasive cross-sectional imaging of ocular tissues. This PowerPoint covers an overview of the technique with excellent diagrams and images. Anatomy: Retina; Anterior eye segment; Cornea; Macula Lutea; Vitreous body; Optic nerve; Retinal ganglion ce...Tomography, Optical Coherence; Retina; Anterior Eye Segment; Cornea; Macula Lutea; Vitreous Body; Optic Nerve; Retinal Ganglion Cells; Retinal Diseases; Glaucoma; Macular Edema; Retinal Edema; NFLA Optical Coherence Tomography
21 Optic Nerve Tumors: Diagnosis and TherapyAlfredo A. Sadun, MD, PhD, Flora L. Thornton Chair, Professor of Ophthalmology and Neurological Surgery, Keck School of Medicine at USCPowerppoint lecture covers a patient case, differential diagnosis, and optic nerve anatomy. Also includes examination information, fundus images and visual field defects. Presenting Symptom: Proptosis; Hemianopsia; Scotoma. Anatomy: Optic nerve; Structure of pituitary fossa; Optic nerve sheath. Dise...Optic Nerve; Structure of Pituitary Fossa; Optic Nerve Sheath; Proptosis; Hemianopsia; Scotoma; Optic Nerve Neoplasms; Meningioma; Optic Nerve Glioma; Chiasmal Visual Field Defects
22 Leber's Hereditary Optic Neuropathy (LHON): New Rules of EngagementAlfredo A. Sadun, MD, PhD, Flora L. Thornton Chair, Professor of Ophthalmology and Neurological Surgery, Keck School of Medicine at USCSlide presentation with several images of optic nerve and optic disk with LHON. Anatomy: Optic nerve; Optic disk; Retinal ganglion cells; Reactive oxygen species. Disease/Diagnosis: Optic Atrophy, Hereditary, Leber. Presenting Symptom: Blindness.Optic Atrophy; Hereditary; Leber; Apoptosis; Cell Death; Blindness; Brazil; Optic Nerve; Optic Disk; Retinal Ganglion Cells; Reactive Oxygen Species
23 Pentoxifylline Suppression of TNF-Alpha Mediated Axonal Degeneration in the Rabbit Optic NerveAlfredo A. Sadun, MD, PhD, Flora L. Thornton Chair, Professor of Ophthalmology and Neurological Surgery, Keck School of Medicine at USCPresenting Symptom: Dyschromatopsia. Anatomy: Optic nerve. Disease/Diagnosis: Acquired Immunodeficiency Syndrome; Demyelinating autoimmune diseases, CNS. Treatment: Pentoxifylline.Pentoxifylline; Optic Nerve; Acquired Immunodeficiency Syndrome; Demyelinating Autoimmune Diseases, CNS; Dyschromatopsia; Tumor Necrosis Factor-Alpha
24 Optic Nerve Sheath Decompression in the Management of Optic NeuropathiesAlfredo A. Sadun, MD, PhD, Flora L. Thornton Chair, Professor of Ophthalmology and Neurological Surgery, Keck School of Medicine at USCA slide presentation with several images of optic disc, normal and with edema. Anatomy: Optic nerve; Optic disc. Disease/Diagnosis: Optic neuropathy, Ischemic; Pseudotumor cerebri; Papilledema. Treatment: Decompression, Surgical.Decompression, Surgical; Optic Neuropathy, Ischemic; Pseudotumor Cerebri; Papilledema; Optic Nerve; Optic Disc
25 Optic Neuritis Treatment TrialsAlfredo A. Sadun, MD, PhD, Flora L. Thornton Chair, Professor of Ophthalmology and Neurological Surgery, Keck School of Medicine at USCAnatomy: Optic nerve. Disease/Diagnosis: Optic neuritis; Multiple sclerosis. Treatment: Methylprednisolone; Prednisone; Solumedrol.Optic Neuritis; Multiple Sclerosis; Optic Nerve; Methylprednisolone; Prednisone; Solumedrol
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