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Gene Mediated Therapy for LHON | Guy, John | Leber Hereditary Optic Neuropathy (LHON) is a maternally inherited disorder that results in loss of vision during the 2nd and 3rd decades of life. The G to A transition at nucleotide 11778 in mitochondrial DNA (mtDNA) in the gene specifying the NADH dehydrogenase subunit 4 (ND4) of complex I causes ... | 20070212_nanos_novelnotreatmentsympos_08.pdf |