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Erectile Dysfunction Drugs and the Eye | Howard D. Pomeranz, MD | The erectile dysfunction (ED) drugs, sildenafil, tadalafil and vardenafil, are selective inhibitors of cyclic guanosine monophosphate (cGMP)-specific phosphodiesterase (PDE) type 5, an enzyme present in vascular smooth muscle. Through this mechanism, the ED drugs potentiate the nitric oxide-cGMP pat... | 20060227_nanos_iatrogenicnosympos_04.pdf |