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201 Garber, SarahNeurosurgical complications of direct thrombin inhibitors - catastrophic hemorrhage after mild traumatic brain injury in a patient receiving dabigatranDabigatran etexilate is an oral anticoagulant that acts as a direct, competitive thrombin inhibitor. Large randomized clinical trials have shown higher doses of dabigatran (150 mg taken twice daily) to be superior to warfarin in terms of stroke and systemic embolism rates in patients with nonvalvula...2012-01-01
202 Couldwell, William T.Neurosurgical implications of allergic fungal sinusitisObject. Allergic fungal sinusitis (AFS) is a form of paranasal mycosis that often involves bone destruction and extension into the orbit and anterior skull base. Treatment consists of surgical extirpation and a course of corticosteroids. Despite frequent intracranial involvement, AFS is rarely repor...2004
203 Couldwell, William T.Neurosurgical workforce trends in the United StatesObject. The purpose of this study was to evaluate the US neurosurgery workforce by reviewing journal recruitment advertisements published during the past 10 years. Methods. The number of available academic and private neurosurgical staff positions was determined based on recruitment advertisements ...2005-02
204 Couldwell, William T.No ordinary time, no ordinary men: the relationship between Harvey Cushing and Franklin D. Roosevelt, 1928-1939The authors elucidate the strong personal relationship that developed between Dr. Harvey Cushing and Franklin Delano Roosevelt (FDR) from 1928 to 1939, as manifested in their frequent letters to each other. The relationship was initiated by the marriage of their children. Through his correspondence ...2001
205 Kestle, John R. W.; Walker, Marion L.Noncommunicating spinal extradural arachnoid cyst causing spinal cord compression in a childExtradural arachnoid cysts in the spine are relatively uncommon causes of spinal cord compression in the pediatric population that are thought to arise from congenital defects in the dura mater. Most reports describe such cysts communicating with the intrathecal subarachnoid space through a small de...2006
206 Couldwell, William T.Normal dimensions of the posterior pituitary bright spot on magnetic resonance imaging: Clinical articleObject. The normal pituitary bright spot seen on unenhanced T1-weighted MRI is thought to result from the T1-shortening effect of the vasopressin stored in the posterior pituitary. Individual variations in its size may be difficult to differentiate from pathological conditions resulting in either ab...2014-01-01
207 Couldwell, William T.Norman Dott, Gerard Guiot, and Jules Hardy: key players in the resurrection of transsphenoidal surgeryDeveloped over a century ago, the introduction of the transsphenoidal approach to access lesions of the pituitary gland and sella turcica has transformed the field of neurosurgery, largely due to the work of Oskar Hirsch and Harvey Cushing. Furthermore, its use and modification in the early 1900s wa...2012-01-01
208 Couldwell, William T.; Orlandi, Richard R.; Apfelbaum, Ronald I.Novel closure technique for the endonasal transsphenoidal approach: Technical noteTranssphenoidal microsurgery has been the standard approach to sellar lesions since the repopularization of the technique with modifications by Dott, Guiot, and Hardy. The endonasal transseptal transsphenoidal approach, as introduced by Hirsch, is still commonly used by pituitary surgeons to remove ...2004
209 Couldwell, William T.; Gillespie, David L.; Jensen, Randy L.Novel model of intracranial meningioma in mice using luciferase-expressing meningioma cellsObject. Meningioma research has been hindered by the inability to sequentially measure intracranial tumor growth in a cost-effective, efficient manner. Recently, the luciferase gene has been transfected into cancer lines to obtain cells that express the luciferase enzyme, which oxidizes luciferin in...2008-01-01
210 Kestle, John R. W.; Brockmeyer, Douglas LeeOptic pathway gliomas: a reviewOptic pathway gliomas represent approximately 3-5% of childhood intracranial tumors. They usually occur in children during the first decade of life and are seen in 11-30% of patients with neurofibromatosis Type 1 (NF1). Although these tumors are typically low-grade gliomas, the clinical course and n...Optic pathway glioma; Hypothalamus glioma; Neurofibromatosis Type 12007
211 Couldwell, William T.OR noise: the potential for hearing lossWith the use of the electric or air-powered drill in cranial or spinal procedures comes the potential for hearing loss among operating team members. Exposure to loud noise can result in sensorineural hearing loss, and this loss is a function of sound pressure levels and duration of exposure. Much r...2008-01-01
212 Couldwell, William T.; Harnsberger, H. RicOronasopharyngeal chordomasBackground: Chordomas are rare tumors derived from notochordal remnants. The authors report on a series of three cases of primary familial oronasopharyngeal chordomas treated at our institution. Methods: A retrospective chart review was completed of the three cases of primary familial oronasopharyng...Oronasopharyngeal; Chordoma; Pharynx; Notochord; Transoral; Skull base2009
213 Kestle, John R. W.; Brockmeyer, Douglas LeeOutcomes after decompressive craniectomy for severe traumatic brain injury in childrenObject. Severe traumatic brain injury (TBI) is often accompanied by early death due to transtentorial herniation. Decompressive craniectomy, performed alone or in conjunction with evacuation of the mass lesion, can reduce the incidence of raised intracranial pressure (ICP). In this paper the authors...Traumatic brain injury; Decompressive craniectomy; Pediatric neurosurgery2006
214 Couldwell, William T.Pallidotomy in advanced Parkinson's diseaseTo the Editor: We read with interest the comments published regarding our recent article on pallidotomy in patients with advanced Parkinson's disease (3). There seems to be confusion as to some of the technical methods used in creating the radiofrequency lesions in these patients. As noted in the Pa...Pallidotomy; Dyskinesia1995
215 Couldwell, William T.Paradoxical elevation of Ki-67 labeling with protein kinase inhibition in malignant gliomasThe monoclonal antibody Ki-67 recognizes a nuclear antigen expressed in the G1, S, G2, and M phase of the cell cycle and has been used extensively as an indicator of cellular proliferation in malignant gliomas, both in the laboratory and clinically. Recently, protein kinase C (PKC) inhibitors have b...Brain neoplasm; Chemotherapy; Glioma; Monoclonal antibody; Ki-67; Protein kinase C; Tamoxifen1995
216 Dailey, Andrew T.Paragangliomas of the sellar region: report of two casesTWO CASES OF paraganglioma arising from the parasellar region are presented. Both occurred in middle-aged women who sought treatment of headaches but who had no endocrinological dysfunction; one case was associated with ophthalmoplegia from cavernous sinus involvement. Diagnosis in both cases was ...Paragangliomas; Sellar region; Parasellar region; Chemodectoma; Pituitary tumor1993
217 Dailey, Andrew T.Pathophysiology of oral pharyngeal apraxia and mutism following posterior fossa tumor resection in childrenMutism following posterior fossa tumor resection in pediatric patients has been previously recognized, although its pathophysiology remains unclear. A review of the available literature reveals 33 individuals with this condition, with only a few adults documented in the population. All of these pati...Vermis; Posterior fossa tumor; Pediatric patients1995
218 Couldwell, William T.Penetrating craniocerebral injury resultant from gunshot wounds: gang-related injury in children and adolescentsWE PROSPECTIVELY AND retrospectively reviewed a series of 780 patients who presented to the University of Southern California/Los Angeles County Medical Center with a diagnosis of gunshot wound to the brain during an 8-year period. Of these, 105 were children ranging in age from 6 months to 17 yea...Craniocerebral injury; Los Angeles County General Hospital; University of Southern California School of Medicine1993
219 Schmidt, Meic H.Perioperative complications and neurological outcomes of first and second craniotomies among patients enrolled in the Glioma Outcome ProjectIn many new clinical trials of patients with malignant gliomas surgical intervention is incorporated as an integral part of tumor-directed interstitial therapies such as gene therapy, biodegradable wafer placement, and immunotherapy. Assessment of toxicity is a major component of evaluating these no...Perioperative complications; Neurological outcomes; Glioma Outcome Project2003
220 Couldwell, William T.Personal perspective: AANS Bulletin's momentum continues: new editor considers peer review, practice survey impactWith this issue, I assume the reins as editor of the AANS Bulletin. I am indebted to James Bean, MD, for his extraordinary efforts in this capacity, as witnessed by review of the recent issues published under his leadership. An important initiative put forth by Dr. Bean and the Bulletin Advisory Boa...2005
221 Couldwell, William T.Petroclival meningiomas: surgical experience in 109 casesThe surgical removal of petroclival meningiomas has historically been associated with a high incidence of morbidity and mortality. The 109 consecutive patients included in the present retrospective study represent a combined series of tumors operated on by the four authors during a period from 1980 ...Petroclival meningiomas; Clivus; Brain neoplasm; Petrous bone; Posterior fossa; Skull base tumor1996
222 Schmidt, Meic H.Photodynamic therapyWe appreciate the comments of Drs. Kaye and Hill on our article. We are pleased that these investigators concurred with our impression that photodynamic therapy (PDT) may potentially be useful in the treatment of posterior fossa tumors. Several interesting questions were raised about the technical ...Photodynamic therapy; Photofrin1994
223 Couldwell, William T.Photophobia in a blind patient: an alternate visual pathwayPhotophobia is a common neurological and ophthalmological symptom that has been associated with a growing number of neurosurgical conditions, especially compressive lesions. The exact signaling pathways and neurophysiological features of the disorder are not well understood; however, data from mult...2006-11
224 Digre, Kathleen B.; Couldwell, William T.; Amini, AminPhotophobia in a blind patient: An alternate visual pathway. Case report.Photophobia is a common neurological and ophthalmological symptom that has been associated with a growing number of neurosurgical conditions, especially compressive lesions. The exact signaling pathways and neurophysiological features of the disorder are not well understood; however, data from multi...Photophobia, Blindness, Signaling Pathway, Pretectal Nuclei, Trigeminal Pathway2006-12-14
225 Schmidt, Meic H.Pigmented villonodular synovitis associated with pathological fracture of the odontoid and atlantoaxial instabilityPPigmented villonodular synovitis (PVNS) is a proliferative disorder of the synovium with a predisposition for the appendicular skeleton. Rarely PVNS can arise from the spine, where this disorder usually presents with localized or radicular pain secondary to involvement of the posterior elements. Th...Atlantoaxial instability; Pigmented villonodular synovitis; Odontoid2007
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