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176 Couldwell, William T.Vagus nerve stimulation activates central nervous system structures in epileptic patients during PET H2(15)O blood flow imagingOBJECTIVE: To determine the central areas of activation by vagal nerve stimulation (VNS) in epilepsy. VNS is a promising neurosurgical method for treating patients with partial and secondary generalized epilepsy. The anti-epileptic mechanism of action from VNS is not well understood. METHODS: We p...Epilepsy; Positron emission tomography; Thalamus; Vagus nerve stimulation1996
177 Schmidt, Meic H.Management of brain abscesses associated with halo fixationHalo orthoses are commonly used in the management of a variety of cervical spinal pathological conditions. Although placement of the cranial pins was initially believed to be safe with minimal complications, minor complications related to the cranial pins have the potential to create a setting for ...Cerebral abscess; Cranial pin; Halo orthosis; Halo fixation; Inner table of skull2008
178 Couldwell, William T.Interpositional dural graft technique for the treatment of dural arteriovenous fistulasDural arteriovenous fistulas (dAVFs) are acquired direct arteriovenous shunts that often drain into the dural venous sinus. Treatment options generally involve disrupting the abnormal vascular conduits by using a combination of modalities, including surgical disconnection, radiosurgery, and transar...2007
179 Dailey, Andrew T.Complement depletion reduces macrophage infiltration and activation during Wallerian degeneration and axonal regenerationAfter peripheral nerve injury, macrophages infiltrate the degenerating nerve and participate in the removal of myelin and axonal debris, in Schwann cell proliferation, and in axonal regeneration. In vitro studies have demonstrated the role serum complement plays in both macrophage invasion and activ...1998
180 Schmidt, Meic H.; Apfelbaum, Ronald I.Atlantoaxial transarticular screw fixation: a review of surgical indications, fusion rate, complications, and lessons learned in 191 adult patientsObject. In this, the first of two articles regarding C1-2 transarticular screw fixation, the authors assessed the rate of fusion, surgery-related complications, and lessons learned after C1-2 transarticular screw fixation in an adult patient series. Methods. The authors retrospectively reviewed 191 ...Atlantoaxial junction; Craniocervical junction; Instability; Transarticular screw fixation; Fusion2005
181 Dailey, Andrew T.Intracranial vascular anastomosis using the microanastomotic systemThe authors describe the use of a microanastomotic device to perform intracranial end-to-end vascular anastomoses. Direct end-to-end anastomosis was performed between the superficial temporal artery and branches of the middle cerebral artery (MCA) in three patients. Two patients had moyamoya disease...Microanastomotic system; Intracranial anastomosis; Superficial temporal-middle cerebral artery bypass; Carotid occlusion1998
182 Gottfried, Oren N.; Liu, James K.; Couldwell, William T.Comparison of radiosurgery and conventional surgery for the treatment of Glomus Jugulare tumorsObjective: The optimal management of glomus jugulare tumors remains controversial. Available treatments were once associated with poor outcomes and significant complication rates. Advances in skull base surgery and the delivery of radiation therapy by stereotactic radiosurgery have improved the resu...Glomus Jugulare; Radiosurgery; Radiotherapy; Skull Base; Surgery2004-07-07
183 Couldwell, William T.Photophobia in a blind patient: an alternate visual pathwayPhotophobia is a common neurological and ophthalmological symptom that has been associated with a growing number of neurosurgical conditions, especially compressive lesions. The exact signaling pathways and neurophysiological features of the disorder are not well understood; however, data from mult...2006-11
184 Dailey, Andrew T.Guidelines for the performance of fusion procedures for degenerative disease of the lumbar spine. Part 4: radiographic assessment of fusionStandards. Static lumbar radiographs are not recommended as a stand-alone means to assess fusion status following lumbar arthrodesis surgery. Guidelines. 1) Lateral flexion and extension radiography is recommended as an adjunct to determine the presence of lumbar fusion postoperatively. The lack ...Lumbar fusion; Lumbar spine; Degenerative disease; Practice guidelines; Radiographic assessment2005
185 Kestle, John R. W.Work hour restrictions: impact on neurosurgical resident training at the University of UtahResident work hour restrictions imposed by the Accreditation Council for Graduate Medical Education became effective on July 1, 2003. To evaluate the effect of these regulations on resident operative experience, we reviewed and compared the surgical experience of junior and senior neurosurgical res...Neurosurgical resident training; Work hour restrictions2006
186 Couldwell, William T.Irving S. Cooper and the early surgical management of movement disordersIrving S. Cooper was a pioneer in the field of functional neurosurgery. During his very productive and controversial career, he proposed the surgical treatment of Parkinson disease (PD) by ligating the anterior choroidal artery to control tremor and rigidity. Subsequently, he developed seminal techn...Functional neurosurgery; Movement disorder; Video2001
187 Couldwell, William T.; Yonemura, Kenneth S.Use of the Olympus endoArm for spinal and skull-based transsphenoidal neurosurgeryMinimally invasive surgical techniques have evolved to reduce soft-tissue injury associated with open surgical techniques. The use of endoscopic visualization allows the exposure of deep structures and provides a mechanism to perform all the components of an open surgical procedure through small p...EndoArm; Endoscope; Pneumatic; Skull-based; Transsphenoidal neurosurgery2008
188 Dailey, Andrew T.Magnesium efficacy in a rat spinal cord injury modelObject. Magnesium has been shown to have neuroprotective properties in short-term spinal cord injury (SCI) studies. The authors evaluated the efficacy of magnesium, methylprednisolone, and magnesium plus methylprednisolone in a rat SCI model. Methods. A moderate-to-severe SCI was produced at T9-10 ...Methylprednisolone; Spinal cord injury; Rat model2009
189 Dailey, Andrew T.; Brodke, Darrel S.Utility of helical computed tomography in differentiating unilateraland bilateral facet dislocationsObjective: Diagnosis of cervical facet dislocation is difficult when relying on plain radiographs alone. This study evaluates the interobserver reliability of helical computed tomography (CT) in the assessment of cervical translational injuries, correlates the radiographic diagnosis with intraoper...Facet dislocations; Helical computed tomography; Spinal trauma2009
190 Couldwell, William T.Cranioplasty with the Medpor porous polyethylene Flexblock implantThe authors describe the use of a porous polyethylene Flexblock implant for cosmetic cranioplasty. The implant may be used to cover any small- or medium-sized (< 8 cm) cranial defect, offering similar cosmetic results to standard alloplast cranioplasty while decreasing operation time. The porous i...Cranioplasty; Medpor; Alloplast; Polyethylene; Skull defect1994
191 Couldwell, William T.Cholesteatoma of the clivus case reportObjective: Cholesteatomas (CNS epidermoids) can be found intradurally or extradurally in the central nervous system. Extradural intraosseous lesions are most commonly found in the petrous bone. Design: Case report Clinical Presentation: The authors describe a unique case of a clival cholesteatoma o...2006-01-01
192 Kestle, John R. W.Natural history of cerebral cavernous malformationsTo determine the natural history of brain cavernous malformations, the authors entered patients referred to their center into a prospective registry between 1987 and 1993. All patients underwent magnetic resonance imaging, which showed the typical appearance of this lesion, and conservative manageme...Cavernous malformation; Vascular malformation; Seizure1995
193 Couldwell, William T.Use of the h index in neurosurgeryObject. Assessing academic productivity through simple quantification may overlook key information, and the use of statistical enumeration of academic output is growing. The h index, which incorporates both the total number of publications and the citations of those publications, has been recently ...2009-01-01
194 Couldwell, William T.Malignant glioma-derived soluble factors regulate proliferation of normal adult human astrocytesMalignant gliomas are characteristically surrounded by marked gliosis. To assess whether glioma-derived products contribute to the proliferation of astrocytes, a feature of the gliosis response, we evaluated the influence of culture supernatants from malignant human glioma lines and tumor cyst fluid...Astrocyte; Glioma; Gliosis; Proliferation; Soluble factors1992
195 Couldwell, William T.Surgical approaches to petroclival meningiomas part I: upper and midclival approachesStrictly considered, petroclival meningiomas represent only a percentage of the 10% of all intracranial meningiomas that reside in the posterior fossa. Although not statistically frequent, with their location in proximity to cranial nerves, the basilar artery and its perforating branches, and t...Petroclival meningiomas; Petroclivus; Surgical approach; Upper clivus; Midclivus1994
196 Kestle, John R. W.Determining the best cerebrospinal fluid shunt valve design: the pediatric valve design trialMyriad cerebrospinal fluid shunt valve designs are available (17, IS). None has ever been shown to be superior to another, although claims by neurosurgeons and shunt manufacturers of the merits of particular designs are numerous. Such is the case with two recent shunt valve designs, the Orbis-Sigm...Pediatric valve design; Shunt valves1996
197 Schmidt, Meic H.Titanium cage-assisted polymethylmethacrylate reconstruction for cervical spinal metastasisReconstruction and stabilization of the cervical spine after vertebrectomy is an important goal in the surgical management of spinal metastasis. The authors describe their reconstruction technique using a titanium cage-Silastic tube construct injected with polymethylmethacrylate (PMMA) augmented by...Titanium cage; Cervical spine; Cervical spinal metastasis; Reconstruction; Vertebrectomy; PMMA reconstruction; Silastic tube2005
198 Couldwell, William T.Submandibular-infratemporal interpositional carotid artery bypass for cranial base tumors and giant aneurysmsCerebral revascularization is an important strategy in the surgical management of some complex cranial base tumors and unclippable aneurysms. A highflow bypass may be necessary in planned carotid occlusion or sacrifice. The cervical-to-supraclinoid internal carotid artery bypass or cervical carotid-...Internal carotid artery; Cranial base tumors; Giant aneurysms; Interpositional bypass; Surgical approach; Radial artery; Revascularization; Saphenous vein; Submandibular infratemporal bypass2006
199 Dailey, Andrew T.Vertebral artery injuries associated with cervical spine injuries: a review of the literatureObjective: To determine the incidence of vertebral artery injuries (VAIs) in association with cervical spine trauma and investigate the optimum diagnostic and treatment protocols. Summary of Background Data: VAIs may result from cervical spine trauma and have the potential to cause cerebral, brain...Cervical spine injuries; Literature review2008
200 Couldwell, William T.Irving S. Cooper (1922-1985): a pioneer in functional neurosurgeryIrving S. Cooper (1922-1985), the son of a salesman, worked his way through high school, college, and medical school to become one of the pioneers in functional neurosurgery. He developed several novel techniques for the surgical management of Parkinson's disease and other crippling movement disord...Functional neurosurgery; Cryosurgery; Dystonia; Movement disorder; Parkinson's disease; Thalamotomy; Tremor; Neurosurgical history1998
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