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151 Normann, Richard A.; Maynard, Edwin M.Neural interface for a cortical vision prosthesisThe development of a cortically based vision prosthesis has been hampered by a lack of basic experiments on phosphene psychophysics. This basic research has been hampered by the lack of a means to safely stimulate large numbers of cortical neurons. Recently, a number of laboratories have developed a...Neuroprosthetics; Artificial Vision; Electrode Arrays; Multielectrode Recordings; Biocompatibility1999
152 Olson, Randall J.; Crandall, Alan S.; Caldwell, Karin D.; Jensen, Michael K.Intraoperative crystallization on the intraocular lens surfacePURPOSE: To report a physician survey, laboratory studies, and clinical observations of intraoperative crystallization on the surface of the intraocular lens (IOL). METHOD: We sent a survey to all ophthalmologists in the states of Wyoming, Idaho, Montana, Utah, and Colorado asking whether crystalliz...Cataract Extraction; Intraoperative Complications; Risk Factors1998-08
153 Normann, Richard A.; Kolb, HelgaNeural organization of the retina of the turtle Mauremys caspica: a light microscope and Golgi studyThe organization of the retina of the turtle species Mauremys caspica, found in fresh water ponds of Israel, has been examined by light microscopical techniques including examination of fresh wholemount retina, one micron blue-stained vertical sections and Golgi-stained material. The anatomical find...Turtle Retina; Photoreceptors; Golgi Technique; Amarcine Cells1988
154 Olson, Randall J.Cohort study of 27 cases of endophthalmitis at a single institutionPURPOSE: To identify potential risk factors associated with post-cataract surgery bacterial endophthalmitis. SETTING: The John A. Moran Eye Center, Salt Lake City, Utah, USA. METHODS: This retrospective cohort study consisted of patients who had surgery for cataract(s) at this eye hospital. A 10% sa...Cataract Extraction; Endophthalmitis; Wound Healing; Risk Factors2005-04
155 Angelucci, AlessandraLayer-specific programs of development in neocortical projection neuronsHow are long-range axonal projections from the cerebral cortex orchestrated during development? By using both passively and actively transported axonal tracers in fetal and postnatal ferrets, we have analyzed the development of projections from the cortex to a number of thalamic nuclei. We report th...Axonal Transport; Efferent Pathways; Brain Mapping1995
156 Digre, Kathleen B.CT and hemifacial spasm.Forty-six patients with typical hemifacial spasm had CT. Thirty-eight (83%) were abnormal, including two with surgically documented tumors. Thirty-six had a characteristic dolichoectatic vertebrobasilar artery, with the convexity pointing to the side of the spasm in 92% of the scans. This study sugg...Hemifacial spasms; Tumors; Dolichoectiatic vertebrobasilar artery1988-07
157 Bernstein, Paul S.; Leppert, Mark F.Genotype-phenotype analysis of ABCR variants in macular degeneration probands and siblingsPURPOSE: Single-copy variants of the autosomal recessive Stargardt disease (STGD1) gene ABCR (ABCA4) have been shown to confer enhanced susceptibility to age-related macular degeneration (AMD). To investigate the role of ABCR alleles in AMD further, genotype-phenotype analysis was performed on sibli...DNA Mutational Analysis; Nuclear Family; Phenotype2002
158 Olson, Randall J.; Samore, Matthew H.; Pace, Nathan L.Dysphotopsia in phakic and pseudophakic patients: incidence and relation to intraocular lens type(2)PURPOSE: To determine the relationship between various intraocular lens (IOL) types and the incidence of unwanted light images. SETTING: The Moran Eye Center, University of Utah, Salt Lake City, Utah, USA. METHODS: A telephone questionnaire was administered to 302 postoperative patients who had rece...Cataract Extraction; Visual Acuity; Lenses, Intraocular; Lens Implantation, Intraocular2000-06
159 Baehr, WolfgangHuman interstitial retinoid-binding protein. Gene structure and primary structureInterstitial retinoid-binding protein (IRBP) is synthesized and secreted by rod photoreceptor cells into the interphotoreceptor matrix and is known to bind retinoids and fatty acids. We have used cDNA clones encoding human IRBP to isolate a 15-kilobase genomic fragment that encompasses the complete ...Molecular Sequence Data; Eye Proteins; Retinol-Binding Proteins; Messenger RNA1989-05-15
160 Baehr, Wolfgang; Rao, Narayanam V.Molecular characterization of a third member of the guanylyl cyclase-activating protein subfamilyThe mammalian retina contains at least two guanylyl cyclases (GC1 and GC2) and two guanylyl cyclase-activating proteins (GCAP1 and GCAP2). Here we present evidence of the presence of a new photoreceptor-specific GCAP, termed GCAP3, which is closely related to GCAP1. The sequence similarity of GCAP3 ...Amino Acid Sequence; Cloning, Molecular; Gene Expression Regulation1999
161 Frederick, Jeanne M.Neurotransmitter properties of the newborn human retina.Human retinal tissue from a newborn was examined autoradiographically for the presence of highaffinity uptake and localization of the following putative neurotransmitters: dopamine, glycine, GAB A, aspartate, and glutamate. In addition, the dopamine content of this newborn retina was measured by ...Newborn; Human Retina; Neurotransmitter Properties; Photoreceptors1983
162 Normann, Richard A.Effects of GABA and related drugs on horizontal cells in the isolated turtle retinaThe role of GABA in the outer plexiform layer of the turtle retina has been examined by intracellular recordings from L- and C-type horizontal cells in the isolated retina preparation. GABA (1-5 mM) slightly depolarized the L-type horizontal cells, reduced the amplitude of their photoresponses, and ...Retina; Horizontal Cells; Synapse; Negative Feedback; GABA; Turtle1990
163 Normann, Richard A.; Clark, Gregory A.; McDonnall, DanielSelective motor unit recruitment via intrafascicular multielectrode stimulationRecruitment of force via independent asynchronous firing of large numbers of motor units produces the grace and endurance of physiological motion. We have investigated the possibility of reproducing this physiological recruitment strategy by determining the selectivity of access to large numbers of ...Funtional Neuromuscular Stimulation; Microelectrode Array; Neuroprosthesis; Intrafascicular Multielectrode Stimulation; Cats2004
164 Baehr, WolfgangCharacterization of the chicken GCAP gene array and analyses of GCAP1, GCAP2, and GC1 gene expression in normal and rd chicken pinealPURPOSE: This study had three objectives: (1) to characterize the structures of the chicken GCAP1 and GCAP2 genes; (2) to determine if GCAP1, GCAP2, and GC1 genes are expressed in chicken pineal gland; (3) if GC1 is expressed in chicken pineal, to determine if the GC1 null mutation carried by the re...Molecular Sequence Data; Promoter Regions (Genetics); Retinal Degeneration1999
165 Baehr, WolfgangRole of photoreceptor-specific retinol dehyrogenase (prRDH) in the retinoid cycle in vivoThe retinoid cycle is a recycling system that replenishes the 11-cis-retinal chromophore of rhodopsin and cone pigments. Photoreceptor-specific retinol dehydrogenase (prRDH) catalyzes reduction of all-trans-retinal to all-trans-retinol and is thought to be a key enzyme in the retinoid cycle. We d...Rhodopsin, Photoreceptors; prRDH (RDH8); All-trans-RDH; A2E; Retinoid cycle; Dark adaptation2005
166 Bernstein, Paul S.Transformations of selected carotenoids in plasma, liver, and ocular tissues of humans and in nonprimate animal modelsPURPOSE: To determine the stereochemistry of carotenoids in human ocular tissues in comparison with plasma and liver and to elucidate the possible transformations of dietary (3R,3'R,6'R)-lutein and (3R,3'R)-zeaxanthin in the eye. Similarly, to characterize the carotenoid profiles in the eye tissues,...Chromatography, High Pressure Liquid; Stereoisomerism; Xanthophylls2002
167 Baehr, WolfgangMolecular characterization of human and mouse photoreceptor guanylate cyclase-activating protein (GCAP) and chromosomal localization of the human geneGuanylate cyclase-activating protein (GCAP) is a novel Ca(2+)-binding protein that stimulates synthesis of cGMP in photoreceptors. Molecular cloning of human and mouse GCAP cDNA revealed that the known mammalian GCAPs are more than 90% similar, consist of 201-205 amino acids, and contain three ident...Amino Acid Sequence; Base Sequence; Cloning, Molecular1994
168 Normann, Richard A.; Abbasi, Masoud; Johansson,TorbjornSilicon carbide enhanced thermomigrationThe widespread acceptance of thermomigration technology to produce through-chip interconnects has been impaired by (i) a random walk of the Si-Al liquid eutectic inclusion as it traverses the wafer, and (ii) a ?surface barrier? which allows thermomigration of only relatively large inclusions. In ...Silicon Dioxide; Thermometers; Transducers; Thermomigration Technology; Infrared Lamps1992
169 Bernstein, Paul S.Identification of lutein and zeaxanthin oxidation products in human and monkey retinasPURPOSE: To characterize fully all the major and minor carotenoids and their metabolites in human retina and probe for the presence of the oxidative metabolites of lutein and zeaxanthin. METHODS: Carotenoids of a composite of 58 pairs of human retinas and a monkey retina were elucidated by comparing...Mass Spectrometry; Oxidation-Reduction; Spectrophotometry, Ultraviolet1997
170 Baehr, Wolfgang; Zhang, KangElovl4 mRNA distribution in the developing mouse retina and phylogenetic conservation of Elovl4 genesPURPOSE: Stargardt-like macular dystrophy (STGD3) is an autosomal dominant form of early onset macular degeneration. The disease causing gene ELOVL4 encodes a protein that belongs to a family of proteins functioning in elongation of long chain fatty acids. The purpose of this study is to characteriz...Amino Acid Sequence; Cloning, Molecular; Molecular Sequence Data2003
171 Digre, Kathleen B.; Warner, Judith E. A.; Bernstein, Paul S.; Alder, Stephen C.Vitamin A in the cerebrospinal fluid of patients with and without idiopathic intracranial hypertensionWe quantified vitamin A in the cerebrospinal fluid of patients with idiopathic intracranial hypertension, elevated intracranial pressure of other causes and normal intracranial pressure. Vitamin A could be detected by high-pressure liquid chromatography in most of the specimens. There was a signific...Chromatography, High Pressure Liquid; Headache2002-11
172 Crockett, David K.Utility of gene-specific algorithms for predicting pathogenicity of uncertain gene variantsThe rapid advance of gene sequencing technologies has produced an unprecedented rate of discovery for genome variation in humans. A growing numbered of authoritative clinical repositories archive gene variants and disease phenotype, yet there are currently many more gene variants that lack clear ann...2012
173 Kleinschmidt, Julia J.; Grosshans, Onie; Caserta, Michael; Saffel-Shrier, Susan; Tuohig, GailIntervening in midlife for optimal retirement: a guide for health educatorsFactors contributing to successful retirement deserve increased attention given the rapid growth of the aging population. Antecedent to successful retirement is successful aging. The middle aged population is an opportune target for health promotion and health education interventions as this group...Retirement; Aging Process;Education Interventions; Health Promotion1991-10
174 Baehr, WolfgangLight-dependent changes in G-protein binding to ROS membranes in intact Bufo retinasLight-dependent changes in the binding of G-protein were analyzed in outer segment disk membranes obtained from photoreceptors of the toad (Bufo marinus) retina. Isolated, intact retinas, incubated in oxygenated Ringer's solution at 23 +/- 1 degree C, were subjected to various conditions of illumina...Centrifugation, Density Gradient; Membranes; Adaptation, Physiological1986
175 Angelucci, AlessandraSegregation and overlap of callosal and association neurons in frontal and parietal cortices of primates: a spectral and coherency analysis.The spatial relations between selected classes of association and callosal neurons were studied in the frontal and parietal lobes of the macaque monkey using retrogradely transported fluorescent dyes. Fast blue and nuclear yellow were injected in the left frontal (areas 4 and 6) and right posterior ...Macaca fascicularis; Parietal Lobe; Neurons1989
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