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CreatorTitleDescriptionSubjectDate
151 Capecchi, Mario R.Critical role of tissue angiotensin-converting enzyme as revealed by gene targeting in miceAngiotensin-converting enzyme (ACE) generates the vasoconstrictor angiotensin II, which plays a critical role in maintenance of blood pressure in mammals. Although significant ACE activity is found in plasma, the majority of the enzyme is bound to tissues such as the vascular endothelium. We used ta...Blood pressure; ACE activity; Enzyme1997-03-06
152 Coley, Phyllis D.; Kursar, Thomas A.Colonization of tropical rain forest leaves by epiphylls: effects of site and host plant leaf lifetimeIn humid tropical regions, leaves are frequently colonized by epiphylls (Richards 1954, Pocs 1978, 1982). Lichens and liverworts usually dominate, although mosses, algae, and cyanobacteria can also occur (Winkler 1971, Smith 1982). The interactions between epiphylls and host leaves have not been wel...Tropical forest; Epiphylls; Panama; Hybanthus prunifolius; Light interception1993
153 Beckerle, Mary C.; Hoffman, Laura M.Targeted disruption of the murine zyxin geneZyxin is an evolutionarily conserved protein that is concentrated at sites of cell adhesion, where it associates with members of the Enabled (Ena)/vasodilator-stimulated phosphoprotein (VASP) family of cytoskeletal regulators and is postulated to play a role in cytoskeletal dynamics and signaling.Zyxin2003
154 Capecchi, Mario R.N-formylmethionyl-sRNA as the initiator of protein synthesis.A bizarre fast about Nterminal groups of bacterial proteins. Instead of a random mixture, that the great majority of N-terminal groups were either methionine or alanine. This finding suggested that methionine and alanine constituted start signals for the initiation of polypeptide chains. Alternative...Electrophoresis; Formates; In Vitro; Methionine1966-01-01
155 Capecchi, Mario R.Mice lacking endothelial angiotensin-converting enzyme have a normal blood pressureTo test the hypothesis that local vascular production of angiotensin II is necessary for the normal regulation of blood pressure, we engineered a new line of genetically altered mice that lack endothelial angiotensin-converting enzyme (ACE). This was accomplished using a novel strategy of targeted...2002
156 Adler, Frederick R.Effect of 1918 PB1-F2 expression on influenza A virus infection kineticsAbstract Relatively little is known about the viral factors contributing to the lethality of the 1918 pandemic, although its unparalleled virulence was likely due in part to the newly discovered PB1-F2 protein. This protein, while unnecessary for replication, increases apoptosis in monocytes, alter...2011
157 Hughes, Kelly T.Flagellar anti-σ factor FlgM actively dissociates Salmonella typhimurium σ28 RNA polymerase holoenzymeThe anti-σ factor FlgM of Salmonella typhimurium inhibits transcription of class 3 flagellar genes through a direct interaction with the flagellar-specific σ factor, σ28. FlgM is believed to prevent RNA polymerase (RNAP) holoenzyme formation by sequestering free σ28. We have analyzed FlgM-media...sigma-factors; transcription; FlgM; Flagellum1998
158 Beckerle, Mary C.Identification of a new protein localized at sites of cell-substrate adhesionA new protein found at sites of cellsubstrate adhesion has been identified by analysis of a nonimmune rabbit serum. By indirect immunofluorescence this serum stains focal contacts (adhesion plaques) and the associated termini of actin filament bundles in cultured chicken cells.Actin; Nonimmune rabbit serum; Polypeptide1986
159 Beckerle, Mary C.; Yoshigi, Masaaki; Hoffman, Laura M.; Yost, H. JosephMechanical force mobilizes zyxin from focal adhesions to actin filaments and regulates cytoskeletal reinforcementOrgans and tissues adapt to acute or chronic mechanical stress by remodeling their actin cytoskeletons. Cells that are stimulated by cyclic stretch or shear stress in vitro undergo bimodal cytoskeletal responses that include rapid reinforcement and gradual reorientation of actin stress fibers; howev...Zyxin; Actin2005
160 Goller, FranzContributions of expiratory muscles to song production in zebra finchesBirdsong production requires coordinated activity of syringeal and respiratory muscles, Phonation occurs during the expiratory phase of the respiratory cycle, and expiratory muscles generate the pressure head for sound production.Phonation; Syringeal muscles; Air sac pressure1999
161 Jorgensen, ErikFunction and misfunction of the two promoters of the Drosophila Antennapedia geneIn the Antennapedia (Antp) gene of Drosophila melanogaster, structurally distinct RNAs arise from different transcription initiation sites. When the two sites are separated by a chromosome inversion, transcripts are produced from each fragment of the split Antp locus, and these RNAs initiate at the ...RNA; Antp; Hybridization1987
162 Seger, JonSexual dimorphism in the HymenopteraSpectacular sex differences of many kinds occur abundantly among the wasps, bees and ants that make up the insect order Hymenoptera. In some cases these differences are so extreme that males and females of the same species have been classified in different genera for decades, until a chance observa...Reproductive; Insect; Morphology1994
163 Davidson, Diane W.Ecological studies of neotropical ant-gardensIn a census taken in Peru's Manu National Park, 10 epiphytic angiosperms from seven plant families established principally on arboreal carton-ant nests. These "ant gardens" (AGs) were most often inhabited by parabiotic ants, Camponotus femoratus and Crematogaster cf. limata parabiotica, whose polygy...Ant competition; Ant garden; Ant-plant interaction; Coadaptation; Epiphyte; Mutualism; Parabiosis; Preadaptation; Peru; Seed dispersal; Tropical rainforest1988
164 Olivera, Baldomero M.; Gray, William RobertConotoxin MI: disulfide bonding and conformational statesThe toxic peptide from Conus magus venom (conotoxin MI) is a 14-amino acid peptide (McIntosh, M., Cruz, L. J., Hunkapiller, M. W., Gray, W. R., and Olivera, B. M. (1982) Arch. Biochem. Biophys. 218, 329-334) which inhibits the acetylcholine ceptor. In this work we have confirmed the primary structu...Conotoxins; Disulfide bonding; Venom; Conus magus1983
165 Beckerle, Mary C.Comparison of three members of the cysteine-rich protein family reveals functional conservation and divergent patterns of gene expressionMembers of the cysteine-rich protein (CRP) family are evolutionarily conserved proteins that have been implicated in the processes of cell proliferation and differentiation. In particular, one CRP family member has been shown to be an essential regulator of cardiac and skeletal muscle development.LIM domains; Chicken fibroblasts; Zyxin; Actinin; Protein expression; Cysteine-rich proteins1997
166 Olivera, Baldomero M.Preliminary study of Conus venom proteinALTHOUGH THE TOXICITY of venoms of the genus Conus has been known since a report by RUMPHIUS in 1705 (VAN BENTHEM-JUTTINO, 1959), these venoms have been studied only intermittently since. Biochemical studies have not been carried out to any great extent; the last major study on the biochemistry of...Conotoxins; Conus venom1976
167 Capecchi, Mario R.Introduction: the molecular genetic analysis of mouse developmentThis paper is an introduction of seven different papers presented in "Seminars in developmental biology" on Molecular Genetic Analysis of Mouse Development . The first paper, by Janet Rossant, describes very early mouse development. The second paper, by Frank Conlon and Rosa Beddington provide an i...Embryo Culture Techniques; Genes1995-04
168 Clayton, Dale H.Reciprocal natural selection on host-parasite phenotypesCoevolution is evolution in one species in response to selection imposed by a second species, followed by evolution in the second species in response to reciprocal selection imposed by the first species. Although reciprocal selection is a prerequisite of coevolution, it has seldom been documented in...Host-parasite phenotypes; Ectoparasites; Virulence; Fitness1999
169 Capecchi, Mario R.Mice with enhanced macrophage angiotensin-converting enzyme are resistant to melanomaAngiotensin-converting enzyne (ACE) is a pepitdase responsible for the cleavage of angiotensin I and Several other peptides. Here, gene targeting was used to switch control of the ACE locus from the endogenous promoter to the macrophage-specific c-fms promoter. Challenge of these mice, called ACE 10...Macrophage enzyme; Melanoma resistance; Enhanced macrophage angiotensin-converting enzyme2007
170 Davidson, Diane W.Species diversity and community organization in desert seed-eating antsPatterns of species diversity and community organization in desert seed-eating ants were studied in 10 habitats on a longitudinal gradient of increasing rainfall extending from southeastern California, through southern Arizona, and into southwestern New Mexico. Local communities of harvester ants...Ants; Arizona; California; Communities; Competition; Desert Granivores; Diversity; Insects; New Mexico; Novomessor; Pheidole; Pogonomyrmex; Resource allocation; Veromessor.1977
171 Carrier, David R.Human flight and exercise in microgravityEarly experimenters in human flight learned, sometimes with fatal consequences, that the human body lacks the muscular power to fly (1). Indeed, the power demands are so great that only relatively small animals (less than 12 kg) are able to fly actively due to the interplay of morphologic scaling (m...Human flight; Microgravity2000
172 Potts, Wayne K.Consequences of self and foreign superantigen interaction with specific VB elements of the murine TCR aBThe aB T-cell receptor (TCRaB) recognizes a ligand composed of an antigen fragment complexed with a product of the major histocompatibility complex (MHC). The repertoire of receptors is limited both by the germ line of receptor variable elements and by selective events that take place during T-cell ...Toxins; Repertoire; Expression1989
173 Davidson, Diane W.Ant-plant symbioses in Africa and the neotropics : history, biogeography and diversitySymbiotic ant-plant relationships afford an excellent opportunity to analyze the effects of both historical and ecological factors on the evolution of mutualisms. Occurring in tropical forests throughout the world, all myrmecophytic plants provide food and permanent housing to ants; the ants, in t...Ant-plant symbiosis; Africa; Neotropics; Myrmecophytes; Plant-ants1993
174 Shapiro, Michael D.Divergence, convergence, and the ancestry of feral populations in the domestic rock pigeonDomestic pigeons are spectacularly diverse and exhibit variation in more traits than any other bird species [1]. In The Origin of Species, Charles Darwin repeatedly calls attention to the striking variation among domestic pigeon breeds - generated by thousands of years of artificial selection on a s...2010
175 Coley, Phyllis D.Tritrophic interactions in tropical versus temperate communitiesThe latitudinal gradient in diversity is one of the oldest (e.g., Wallace, 1878) and most obvious trends in ecology, and a wealth of literature is devoted to understanding both the causes and consequences of this gradient (Dobzhansky, 1950; also reviewed by Rohde, 1992). Given the enormous latitudi...Tritrophic interactions; Trophic cascades; Herbivory; Tropical communities; Temperate communities2002
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