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CreatorTitleDescriptionSubjectDate
126 Angelucci, AlessandraSegregation and overlap of callosal and association neurons in frontal and parietal cortices of primates: a spectral and coherency analysis.The spatial relations between selected classes of association and callosal neurons were studied in the frontal and parietal lobes of the macaque monkey using retrogradely transported fluorescent dyes. Fast blue and nuclear yellow were injected in the left frontal (areas 4 and 6) and right posterior ...Macaca fascicularis; Parietal Lobe; Neurons1989
127 Digre, Kathleen B.; Blumenthal, Deborah T.; Salzman, Karen L.; Jensen, Randy L.; Dunson, William A.Early pathologic findings and long-term improvement in anti-Ma2-associated encephalitis.A 67-year-old man sequentially developed anti-Ma2-associated paraneoplastic encephalitis (PNE) and contralateral herpes simplex encephalitis (HSE). Brain biopsy 1 month before HSE revealed extensive infiltrates of T cells, B cells, and plasma cells. Most T cells expressed the cytotoxic granule-assoc...Paraneoplastic neurologic disorders; Encephalitis; Neoplasm;Herpes Simplex2006-07-11
128 Bernstein, Paul S.Retinal tubulin binds macular carotenoidsPURPOSE: To investigate the biochemical mechanisms responsible for the specific uptake, concentration, and stabilization of the carotenoids lutein and zeaxanthin in the macula. METHODS: Soluble extracts of bovine retina mixed with radioactive carotenoids were purified by hydrophobic interaction, ion...Chromatography, Gel; Electrophoresis; Xanthophylls1997
129 Olson, Randall J.Early experiences with microphacoMicrophaco is the separation of irrigation from aspiration that allows removal of cataracts through sub-2mm incisions. While proven intraocular lenses (IOLs) are not available at this time to take advantage of the small wounds, these wounds are advantageous from a separating irrigation standpoint w...Microphaco; Cataracts; Irrigation; Wounds2004
130 Durney, Carl H.An experiment in using interactive computer graphics in teaching transient transmission-line theoryAn interactive computer graphics routine was developed and used in teaching EE 553, Electromagnetic Fields, autumn quarter, 1969, in the Electrical Engineering Department of the University of Utah. The routine displayed the propagation of the voltage ave form produced by a step-function generator do...1970
131 Olson, Randall J.Comparison of thermal features associated with 2 phacoemulsification machinesPURPOSE: To determine the thermal characteristics of the Legacy Advantec and Sovereign WhiteStar phacoemulsification machines during different clinically relevant scenarios. SETTING: In vitro study. METHODS: In water, temperature was recorded continuously on the sleeve in an artificial chamber, and ...Cataracts; Wound Burns; Thermal Characteristics2006-02
132 Zhang, KangExpression of wild type and mutant ELOVL4 in cell culture: subcellular localization and cell viabilityPURPOSE: ELOVL4 is a member of the fatty acid elongase (ELO) family of genes. Mutations of this gene are responsible for autosomal dominant Stargardt-like macular degeneration. However, the specific role of ELOVL4 in photoreceptor cells and the mechanism by which mutations in ELOVL4 causes macular d...Endoplasmic Reticulum; Green Fluorescent Proteins; Microscopy, Fluorescence2004
133 Baehr, WolfgangBilateral retinal and brain tumors in transgenic mice expressing simian virus 40 large T antigen under control of the human interphotoreceptor retinoid-binding protein promoterWe have previously shown that postnatal expression of the viral oncoprotein SV40 T antigen in rod photoreceptors (transgene MOT1), at a time when retinal cells have withdrawn from the mitotic cycle, leads to photoreceptor cell death (Al-Ubaidi et al., 1992. Proc. Natl. Acad. Sci. USA. 89:1194-1198)....Simian virus 40; Retinol-Binding Proteins; Promoter Regions (Genetics)1992
134 Baehr, WolfgangMouse opsin. Gene structure and molecular basis of multiple transcriptsThe single copy mouse opsin gene produces five major transcripts, varying in size from 1.7 to 5.1 kilobases. The mRNAs are present at levels that vary over 2 orders of magnitude and can be detected as early as postnatal day 1. Each of the transcripts is polyadenylated and can be identified in polyso...Polyribosomes; Restriction Mapping; Sequence Homology, Nucleic Acid1990
135 Baehr, Wolfgang; Zhang, KangCharacterization of human GRK7 as a potential cone opsin kinasePURPOSE: Homozygous inactivation of the mouse gene for GRK1 (G protein-coupled receptor kinase 1, or rhodopsin kinase) causes severe defects in the recovery of cone phototransduction. However, electroretinographic (ERG) analyses of human oguchi patients with defective GRK1 alleles showed normal or s...Amino Acid Sequence; Chromosomes, Human, Pair 3; Fluorescent Antibody Technique, Indirect2001
136 Olson, Randall J.Mathematical description of causative factors and prevention of elevated intraocular pressure after keratoplastyIn keratoplasty with grafts the same size as the recipient bed, tight sutures and thick recipient corneal periphery distort the angle and may collapse the filtering meshwork. This can cause very high postoperative pressures, which can be avoided by the use of donor grafts larger than the recipient b...Keratoplasty; Trabecular Collapse; Angle Disrottion; Elevated Pressure; Aphakia; Mathematics1977-12
137 Baehr, Wolfgang; Prestwich, Glenn D.Photoreceptor cGMP phosphodiesterase delta subunit (PDEdelta) functions as a prenyl-binding proteinBovine PDEdelta was originally copurified with rod cGMP phosphodiesterase (PDE) and shown to interact with prenylated, carboxymethylated C-terminal Cys residues. Other studies showed that PDEdelta can interact with several small GTPases including Rab13, Ras, Rap, and Rho6, all of which are prenylate...Fluorescence Resonance Energy Transfer; GTP Phosphohydrolases; Immunohistochemistry2004
138 Jones, Bryan W.; Jones, Christopher R.; Czajkowski, LauraFamilial advanced sleep-phase syndrome: a short-period circadian rhythmvariant in humansBiological circadian clocks oscillate with an approximately 24-hour period, are ubiquitous, and presumably confer a selective advantage by anticipating the transitions between day and night. The circadian rhythms of sleep, melatonin secretion and body core temperature are thought to be generated by ...Activity Cycles; Matched-Pair Analysis; Polysomnography1999
139 Digre, Kathleen B.; Gouw, Launce G.; Harris, Catherine P.; Haines, John H.; Ptacek, L.J.Autosomal dominant cerebellar ataxia with retinal degeneration: clinical, neuropathologic, and genetic analysis of a large kindred.The autosomal dominant cerebellar ataxias (ADCA) comprise a heterogeneous group of neurologic disorders characterized by degeneration of the cerebellum, spinal cord, and brainstem. Genetic analysis has revealed two loci, SCA1 on chromosome 6p, and SCA2 on chromosome 12q, responsible for some ADCA. W...Retinal Degeneration; Cerebellar Ataxia; Genetic Analysis1994-08
140 Digre, Kathleen B.; Kleinschmidt, Julia J.; Hanover, RitaIdiopathic intracranial hypertension. Relationship to depression, anxiety, and quality of lifeOBJECTIVE: To explore the incidence of depression and anxiety and to measure quality of life in women with idiopathic intracranial hypertension (IIH), a matched group cross-sectional study was conducted. Women with IIH (n = 28) were compared with control groups of weight- and age-matched women not d...Intracranial Hypertension; Depression; Anxiety; Quality of Life2000-01-25
141 Varner, Michael W.; Digre, Kathleen B.Pseudotumor cerebri and pregnancy.Pseudotumor cerebri (PTC) is most commonly seen in obese women of reproductive age. We studied 109 women with PTC between ages 16 and 44 years. In 11, PTC started during pregnancy. Thirteen women with previous diagnosis of PTC, including two of the aforementioned 11, had an additional 17 documented ...Pregnancy Complications; Pseudotumor Cerebri; Vision disorders; Headache; Intracranial Pressure1984-06
142 Swallow, Charles E.; Tsuruda, Jay S.; Digre, Kathleen B.; Glaser, Matthew J.; Davidson, H. Christian; Harnsberger, H. RicTerson syndrome: CT evaluation in 12 patients.PURPOSE: Terson syndrome may be overlooked in the acute setting and often requires ophthalmologic intervention to prevent long-term visual loss. In this syndrome, vitreous or retinal hemorrhage results from an abrupt rise in intracranial pressure, leading to retinal venous hypertension and intraocul...Retinal Hemorrhage; Visual Acuity; Vitreous Hemorrhage1998-04
143 Normann, Richard A.Visual Neuroprosthetics: Functional Vision for the BlindResent progress in materials and microfabrication technologies have allowed researchers to reconsider the prospect of providing a useful visual sense to the profoundly blind. This will be accomplished by electrically stimulating their visual systems via an array of implanted microelectrodes. T...Visual Neuroprosthetics; Vision; Blindness1995-01
144 Olson, Randall J.; Crandall, Alan S.; Pingree, Michael F.Cataract surgery complications in 1 year at an academic institutionPURPOSE: To delineate all complication rates of cataract surgery and define normative rates, trends, and outliers as part of continuous quality management. SETTING: John A. Moran Eye Center, University of Utah Health Sciences Center, Salt Lake City, Utah, USA. METHODS: All cataract surgeries done at...Intraoperative Complications/Epidemiology; Adverse Effects; Cataract Surgery1999-05
145 Bernstein, Paul S.; Gellermann, WernerMacular pigment Raman detector for clinical applicationsClinical studies of carotenoid macular pigments (MP) have been limited by the lack of noninvasive, objective instruments. We introduce a novel noninvasive optical instrument, an MP Raman detector, for assessment of the carotenoid status of the human retina in vivo. The instrument uses resonant excit...Diagnosis, Computer-Assisted; Equipment Failure Analysis; Sensitivity and Specificity2004
146 Normann, Richard A.Statistical encoding model for a primary motor cortical brain-computer interfaceA number of studies of the motor system suggest that the majority of primary motor cortical neurons represent simple movement-related kinematic and dynamic quantities in their time-varying activity patterns. An example of such an encoding relationship is the cosine tuning of firing rate with respect...Discrete Distribution; LN Model; Neural Decoding; Neuroprosthetics; Sequential Monte-Carlo Filter2005
147 Jaeckle, Kurt A.; Digre, Kathleen B.; Jones, Christopher R.; Bailey, Peter L.Central neurogenic hyperventilation: pharmacologic intervention with morphine sulfate and correlative analysis of respiratory, sleep, and ocular motor dysfunction.Central neurogenic hyperventilation (CNH), for which there is no effective therapy, can eventually result in respiratory fatigue and death. This report describes a patient with CNH due to a brainstem anaplastic astrocytoma who also exhibited disturbances of sleep and ocular motor function. The CNH r...Central Neurogenic H yperventilation; Ocular Motor Dysfunction1990-11
148 Baehr, WolfgangCalcium-sensitive regions of GCAP1 as observed by chemical modifications, fluorescence, and EPR spectroscopiesGuanylyl cyclase-activating proteins are EF-hand Ca(2+)-binding proteins that belong to the calmodulin superfamily. They are involved in the regulation of photoreceptor membrane-associated guanylyl cyclases that produce cGMP, a second messenger of vertebrate vision. Here, we investigated changes in ...Amino Acid Motifs; Cyclic N-Oxides; EF Hand Motifs2001
149 Baehr, WolfgangCloning of frog rod photoreceptor cGMP phosphodiesterase subunits (P-alpha, P-beta, P-gamma) and identification of P-gamma) sites involved in the stimulation of cGMP binding to P-alpha and P-beta non-catalytic sitesRetinal cGMP phosphodiesterase (PDE6) is a key enzyme in vertebrate phototransduction. Rod PDE contains two homologous catalytic subunits (Pd two identical regulatory subunits (P). Biochemical studies have shown that amphibian P has high affinity, cGMP-specific, non-catalytic binding sites and that ...Phototransduction; Retinal cGMP phosphodiesterase; Amphibian PDE2002
150 Crandall, Alan S.Torn posterior capsule: prevention, recognition and managementModern cataract surgery performed with phacoemulsification allows meticulous intraocular control and minimal incision size, but has the inherent risk of capsular rupture. Therefore, surgeons performing cataract surgery will inevitably face the complication of a torn posterior capsule. Torn posteri...Capsulorrhexis complications; Phacoemulsification; Posterior capsular tears; Shallow anterior chamber; Suprachoroidal hemorrhage; Vitrectomy1999
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