Filters: School Or College: "School of Medicine" Department: "Ophthalmology" Collection: "ir_uspace"
| Creator | Title | Description | Subject | Date | ||
|---|---|---|---|---|---|---|
| 126 |
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Baehr, Wolfgang; Prestwich, Glenn D. | Photoreceptor cGMP phosphodiesterase delta subunit (PDEdelta) functions as a prenyl-binding protein | Bovine PDEdelta was originally copurified with rod cGMP phosphodiesterase (PDE) and shown to interact with prenylated, carboxymethylated C-terminal Cys residues. Other studies showed that PDEdelta can interact with several small GTPases including Rab13, Ras, Rap, and Rho6, all of which are prenylate... | Fluorescence Resonance Energy Transfer; GTP Phosphohydrolases; Immunohistochemistry | 2004 |
| 127 |
 |
Bernstein, Paul S.; Gellermann, Werner | Macular pigment Raman detector for clinical applications | Clinical studies of carotenoid macular pigments (MP) have been limited by the lack of noninvasive, objective instruments. We introduce a novel noninvasive optical instrument, an MP Raman detector, for assessment of the carotenoid status of the human retina in vivo. The instrument uses resonant excit... | Diagnosis, Computer-Assisted; Equipment Failure Analysis; Sensitivity and Specificity | 2004 |
| 128 |
 |
Fuhrmann, Sabine | Expression of CNTF receptor-alpha in chick violet-sensitive cones with unique morphologic properties. | PURPOSE: Application of ciliary neurotrophic factor (CNTF) can rescue mature photoreceptors from lesion-induced and hereditary degeneration. In the chick retina, expression of the CNTF receptor is present in a subpopulation of photoreceptor cells. The present study was undertaken to identify the CNT... | embryology; cytology | 2004 |
| 129 |
 |
Normann, Richard A.; Shoham, Shy | Coding of position by simultaneously recorded sensory neurones in the cat dorsal root ganglion | Muscle, cutaneous and joint afferents continuously signal information about the position and movement of individual joints. How does the nervous system extract more global information, for example about the position of the foot in space? To study this question we used microelectrode arrays to record... | Cats; Sensory Neurones; Movement; Limb Position | 2004 |
| 130 |
 |
Olson, Randall J. | Clinical experience with 21-gauge manual microphacoemulsification using Sovereign WhiteStar Technology in eyes with dense cataract | PURPOSE: To present a series of patients who had 21-gauge microphacoemulsification using Sovereign WhiteStar technology. SETTING: John A. Moran Eye Center, University of Utah School of Medicine, Salt Lake City, Utah, USA. METHODS: Eighteen consecutive patients with cataracts judged to be 3+ or 4+ on... | Cataract; Microsurgery; Phacoemulsification; Postoperative Complications; Visual Acuity | 2004-01 |
| 131 |
 |
Olson, Randall J. | Legacy AdvanTec and Sovereign WhiteStar: a wound temperature study | PURPOSE: To assess the wound temperature of the Sovereign WhiteStar (S-WS) (AMO) and Legacy AdvanTec (L-ADV) (Alcon) phacoemulsification systems. SETTING: John A. Moran Eye Center, Health Sciences Center, University of Utah, Salt Lake City, Utah, USA. METHODS: Phacoemulsification using 20-gauge, 30-... | Eye Burns; Wound Temperature; Phacoemulsification Systems | 2004-05 |
| 132 |
 |
Digre, Kathleen B.; Blumenthal, Deborah T.; Cessna, Melissa H.; Gopez, Evelyn V.; Shen, Yue | Carcinomatous meningitis as the presenting manifestation of gallbladder carcinoma: case report and review of the literature | The primary tumors that typically cause carcinomatous meningitis include lung cancer, breast cancer, leukemia, lymphoma and melanoma. A variety of neurological signs and symptoms can be seen depending on the extent and location of the meningeal metastasis. Once the diagnosis of carcinomatous meningi... | Carcinomatous Meningitis; Gallbladder Carcinoma; Leptomeningeal Metastasis; Meningeal Carcinomatosis; Cranial Neuropathy | 2004-10 |
| 133 |
 |
Olson, Randall J. | Effect of lens edge design versus anterior capsule overlap on posterior capsule opacification | PURPOSE: To determine whether lens edge design or anterior capsule overlap on the intraocular lens (IOL) has greater effect on posterior capsule opacification (PCO). DESIGN: Retrospective cohort clinical study. METHODS: Retrospective. SETTING: Academic clinical practice. PATIENT POPULATION: The pati... | Posterior Capsular Opacification' Intraocular Lens; Anterior Capsular Opacification; Acrylic Lenses; Silicone Lenses | 2004-10 |
| 134 |
 |
Baehr, Wolfgang; Katz, Bradley J.; Creel, Donnell J.; Zhang, Kang | Autosomal dominant cone dystrophy caused by a novel mutation in the GCAP1 gene (GUCA1A) | PURPOSE: To describe the clinical features and genetic analysis of a family with an autosomal dominant cone dystrophy (adCD). METHODS: Selected members of a family with an autosomal dominant cone dystrophy underwent ophthalmic evaluation. Blood samples were obtained, genomic DNA was isolated, and ge... | Mutation, Missense; DNA Mutational Analysis; Electroretinography | 2005 |
| 135 |
 |
Baehr, Wolfgang | Retinoid absorption and storage is impaired in mice lacking lecithin:retinol acyltransferase (LRAT) | Lecithin:retinol acyltransferase (LRAT) is believed to be the predominant if not the sole enzyme in the body responsible for the physiologic esterification of retinol. We have studied Lrat-deficient (Lrat-/-) mice to gain a better understanding of how these mice take up and store dietary retinoids a... | Chromatography, High Pressure Liquid; Mice, Transgenic; Tissue Distribution | 2005 |
| 136 |
 |
Normann, Richard A. | Functional reorganization of primary visual cortex induced by electrical stimulation in the cat. | Compared to the high degree of plasticity observed in a juvenile, mature sensory cortices have long been held to be immutable but, recently, researchers have suggested some plasticity persists in the mature cortex. Cortical reorganization has particular saliency to the development of a cortically ba... | Cat; Electrophysiology; Phosphene; Plasticity; Receptive Field; Striate Cortex | 2005 |
| 137 |
 |
Baehr, Wolfgang | Pharmacological and rAAV gene therapy rescue of visual functions in a blind mouse model of Leber congenital amaurosis | BACKGROUND: Leber congenital amaurosis (LCA), a heterogeneous early-onset retinal dystrophy, accounts for approximately 15% of inherited congenital blindness. One cause of LCA is loss of the enzyme lecithin:retinol acyl transferase (LRAT), which is required for regeneration of the visual photopigmen... | Disease Models, Animal; Genetic Vectors; Molecular Sequence Data | 2005 |
| 138 |
 |
Baehr, Wolfgang | Metabolism and transactivation activity of 13,14-dihydroretinoic acid | The metabolism of vitamin A is a highly regulated process that generates essential mediators involved in the development, cellular differentiation, immunity, and vision of vertebrates. Retinol saturase converts all-trans-retinol to all-trans-13,14-dihydroretinol (Moise, A. R., Kuksa, V., Imanishi, Y... | Chromatography, High Pressure Liquid; Electrophoresis, Polyacrylamide Gel; Retinoid X Receptors | 2005 |
| 139 |
 |
Bernstein, Paul S.; Zabriskie, Norman A.; Zhang, Kang | CFH Y402H Confers similar risk of soft Drusen and both forms of advanced AMD | BACKGROUND: Age-related macular degeneration (AMD) is the most common cause of irreversible visual impairment in the developed world. The two forms of advanced AMD, geographic atrophy and neovascular AMD, represent different pathological processes in the macula that lead to loss of central vision. S... | 2005 | |
| 140 |
 |
Baehr, Wolfgang | Novel GCAP1 missense mutation (L151F) in a large family with autosomal dominant cone-rod dystrophy (adCORD) | PURPOSE: To elucidate the phenotypic and biochemical characteristics of a novel mutation associated with autosomal dominant cone-rod dystrophy (adCORD). METHODS: Twenty-three family members of a CORD pedigree underwent clinical examinations, including visual acuity tests, standardized full-field ERG... | Polymorphism, Single-Stranded Conformational; Guanylate Cyclase-Activating Proteins; DNA Mutational Analysis | 2005 |
| 141 |
 |
Baehr, Wolfgang | Role of photoreceptor-specific retinol dehyrogenase (prRDH) in the retinoid cycle in vivo | The retinoid cycle is a recycling system that replenishes the 11-cis-retinal chromophore of rhodopsin and cone pigments. Photoreceptor-specific retinol dehydrogenase (prRDH) catalyzes reduction of all-trans-retinal to all-trans-retinol and is thought to be a key enzyme in the retinoid cycle. We d... | Rhodopsin, Photoreceptors; prRDH (RDH8); All-trans-RDH; A2E; Retinoid cycle; Dark adaptation | 2005 |
| 142 |
 |
Baehr, Wolfgang | Evaluation of the 17 kda prenyl binding protein as a regulatory protein for phototransduction in retinal photoreceptors | The mammalian rod photoreceptor phosphodiesterase (PDE6) holoenzyme is isolated in both a membrane-associated and a soluble form. Membrane binding is a consequence of prenylation of PDE6 catalytic subunits, whereas soluble PDE6 is purified with a 17-kDa prenyl-binding protein (PDEdelta) tightly boun... | Amino Acid Sequence; Immunohistochemistry; Phosphoric Diester Hydrolases | 2005 |
| 143 |
 |
Normann, Richard A. | Statistical encoding model for a primary motor cortical brain-computer interface | A number of studies of the motor system suggest that the majority of primary motor cortical neurons represent simple movement-related kinematic and dynamic quantities in their time-varying activity patterns. An example of such an encoding relationship is the cosine tuning of firing rate with respect... | Discrete Distribution; LN Model; Neural Decoding; Neuroprosthetics; Sequential Monte-Carlo Filter | 2005 |
| 144 |
 |
Zhang, Kang | Loss of ER retention and sequestration of the wild-type ELOVL4 by Stargardt disease dominant negative mutants | PURPOSE: Mutations in ELOVL4, a member of the fatty acid elongase (ELO) family, are responsible for autosomal dominant Stargardt-like macular degeneration. The specific role of ELOVL4 in photoreceptors and the degenerative events induced by dominant ELOVL4 mutations are not well understood. As a fir... | Macular Degeneration; Transcription Factor CHOP; Molecular Chaperones | 2005 |
| 145 |
 |
Olson, Randall J. | Cohort study of 27 cases of endophthalmitis at a single institution | PURPOSE: To identify potential risk factors associated with post-cataract surgery bacterial endophthalmitis. SETTING: The John A. Moran Eye Center, Salt Lake City, Utah, USA. METHODS: This retrospective cohort study consisted of patients who had surgery for cataract(s) at this eye hospital. A 10% sa... | Cataract Extraction; Endophthalmitis; Wound Healing; Risk Factors | 2005-04 |
| 146 |
 |
Zhang, Kang | Heterozygous and homozygous mutations in PITX3 in a large Lebanese family with posterior polar cataracts and neurodevelopmental abnormalities | PURPOSE: The PITX3 gene, which codes for a homeobox bicoidlike transcription factor is responsible for dominant cataract and anterior segment mesenchymal dysgenesis in humans. In the current study, a family with autosomal dominant posterior polar cataract (PPC) and a PITX3 mutation that cosegregates... | Chromosomes, Human, Pair 10; Homozygote; Lod Score | 2006 |
| 147 |
 |
Warner, Judith E. A. | Intermittent reversal of Complete Ptosis-EganWarner | CASE REPORT: Ptosis secondary to dense oculomotor pareses generally improves over several months, but intermittent elevation of the eyelid has not been reported. The Author's describe two patients who demonstrated intermittent involuntary monocular eyelid elevation in an eye with complete ptosis cau... | Eyelids; Ophthalmoplegia; Intraoperative Complications | 2006 |
| 148 |
 |
Baehr, Wolfgang | Cloning and molecular characterization of cGMP-gated ion channels from rod and cone photoreceptors of striped bass ( M. saxatilis ) retina | Vertebrate photoreceptors respond to light with changes in membrane conductance that reflect the activity of cyclic-nucleotide gated channels (CNG channels). The functional features of these channels differ in rods and cones; to understand the basis of these differences we cloned CNG channels from t... | Amino Acid Sequence; Computational Biology; Reverse Transcriptase Polymerase Chain Reaction | 2006 |
| 149 |
 |
Mamalis, Nick; Nilson, Christian D. | Outbreak of toxic anterior segment syndrome following cataract surgery associated with impurities in autoclave steam moisture. | BACKGROUND: Toxic anterior segment syndrome (TASS), a complication of cataract surgery, is a sterile inflammation of the anterior chamber of the eye. An outbreak of TASS was recognized at an outpatient surgical center and its affiliated hospital in December 2002. METHODS: Medical records of patients... | Toxic anterior segment syndrome; cataract surgery; autoclave steam moisture | 2006 |
| 150 |
 |
Mamalis, Nick; Kleinmann, Guy; Chew, Jesse; Apple, David J. | Suturing a tear of the anterior capsulorhexis | AIM: To describe a new technique of suturing a tear in the anterior capsulorhexis. METHODS: Continuous curvilinear capsulorhexis (CCC) with lens removal was done in five fresh cadaver eyes. The diameter of the CCC was measured with a calliper. Using the same calliper a tear of the CCC was created wh... | Continuous curvilinear capsulorhexis; intraocular lens implantation; tear | 2006 |