Filters: School Or College: "School of Medicine" Collection: "ir_uspace" Type: "Text" Department: "Human Genetics"
| Creator | Title | Description | Subject | Date | ||
|---|---|---|---|---|---|---|
| 101 |
 |
Capecchi, Mario R. | Genetic interaction between hoxb-5 and hoxb-6 is revealed by nonallelic noncomplementation. | hoxb-5 and hoxb-6 are adjacent genes in the mouse HoxB locus and are members of the homeotic transcription factor complex that governs establishment of the mammalian body plan. To determine the roles of these genes during development, we generated mice with a targeted disruption in each gene. Three ... | Alleles; CCAAT-Enhancer-Binding Proteins; Cervical Vertebrae; DNA-Binding Proteins; Forelimb; Genetic Complementation Test | 1995-01-01 |
| 102 |
 |
Capecchi, Mario R. | Absence of radius and ulna in mice lacking hoxa-11 and hoxd-11. | Mice with targeted disruptions in Hox genes have been generated to evaluate the role of the Hox complex in determining the mammalian body plan. This complex of 38 genes encodes transcription factors that specify regional information along the embryonic axes. Early in vertebrate evolution an ancestra... | Alleles; Animals; Bone and Bones; Carpal Bones | 2003-09-02 |
| 103 |
 |
Gesteland, Raymond F.; Letsou, Anthea; Ivanov, Ivaylo P.; Simin, Karl; Atkins, John F. | Drosophila gene for antizyme requires ribosomal frameshifting for expression and contains an intronic gene for snRNP Sm D3 on the opposite strand | Previously, a Drosophila melanogaster sequence with high homology to the sequence for mammalian antizyme (ornithine decarboxylase antizyme) was reported. The present study shows that homology of this coding sequence to its mammalian antizyme counterpart also extends to a 5* open reading frame (ORF... | Ornithine decarboxylase antizyme; Binding proteins | 1998 |
| 104 |
 |
Gesteland, Raymond F.; Atkins, John F.; Baranov, Pavel V. | Diverse bacterial genomes encode an operon of two genes, one of which is an unusual class-I release factor that potentially recognizes atypical mRNA signals other than normal stop codons | ABSTRACT: Background: While all codons that specify amino acids are universally recognized by tRNA molecules, codons signaling termination of translation are recognized by proteins known as class-I release factors (RF). In most eukaryotes and archaea a single RF accomplishes termination at all three... | Class-I release factors; RF1; RF2; Bacterial genomes | 2006 |
| 105 |
 |
Gesteland, Raymond F.; Atkins, John F.; Weiss, Robert B. | Slippery runs, shifty stops, backward steps and forward hops: -2, -1, +1, +2, +5 and +6 Ribosomal frameshifting | Frameshift mutations frequently express residual levels of gene activity; that is, they are often leaky. This leakiness can be used as a tool to define the functional components that affect the reading frame during gene expression. Recent technological advances in the capability to efficiently bu... | Molecular Sequence Data; Mutation; RNA, Transfer; Frameshifting | 1987 |
| 106 |
 |
Capecchi, Mario R. | Illegitimate cre-dependent chromosome rearrangements in transgenic mouse spermatids. | The bacteriophage P1 Cre/loxP system has become a powerful tool for in vivo manipulation of the genomes of transgenic mice. Although in vitro studies have shown that Cre can catalyze recombination between cryptic "pseudo-loxP" sites in mammalian genomes, to date there have been no reports of loxP-si... | Chromatin; Female; Mice, Inbred C57BL; Phenotype | 2000-12-05 |
| 107 |
 |
Gouw, Launce G.; McKenna, Catherine K.; Digre, Kathleen B.; Placek, Louis J. | Analysis of the dynamic mutation in the SCA7 gene shows marked parental effects on CAG repeat transmission. | The gene for spinocerebellar ataxia 7 (SCA7) includes a transcribed, translated CAG tract that is expanded in SCA7 patients. We have determined expansions in 73 individuals from 17 SCA7 kindreds and compared them with repeat lengths of 180 unaffected individuals. Subjects with abnormal expansions co... | Genetics; Biosynthesis; SCA7 Gene | 1998-03-07 |
| 108 |
 |
Capecchi, Mario R. | Cleft palate in mice with a targeted mutation in the gamma-aminobutyric acid-producing enzyme glutamic acid decarboxylase 67. | The functions of neurotransmitters in fetal development are poorly understood. Genetic observations have suggested a role for the inhibitory amino acid neurotransmitter gamma-aminobutyric acid (GABA) in the normal development of the mouse palate. Mice homozygous for mutations in the beta-3 GABAA rec... | Animals, Newborn; Crosses, Genetic | 1997-10-14 |
| 109 |
 |
Capecchi, Mario R. | In vivo and in vitro tissue-specific expression of green fluorescent protein using the cre-lox system in mouse embryonic stem cells. | Embryonic stem cells (ES) are pluripotent and may therefore serve as a source for the generation of specific cell types required for future therapies based on cell replacement. The isolation of defined cell populations from a certain lineage or tissue is a prerequisite for the analysis of the potent... | Animals; Cell Differentiation; Cells, Cultured; Gene Transfer Techniques; Mice, Transgenic | 2005-10-23 |
| 110 |
 |
Auduong, Priscilla; Murphy, Kelley J.; Schmid, Aloisia T. | Spinal muscular atrophy in Drosophila | Spinal Muscular Atrophy (SMA) is the most commonly inherited form of motor neuronal disease in humans and a leading cause of infant mortality. SMA is characterized by a loss of motor neurons which lead to muscle degeneration, paralysis, and eventual death by respiratory failure. More than ninety-f... | Trapeze Interactive Poster | 2010-03-15 |