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101 Olson, Randall J.Comparison of thermal features associated with 2 phacoemulsification machinesPURPOSE: To determine the thermal characteristics of the Legacy Advantec and Sovereign WhiteStar phacoemulsification machines during different clinically relevant scenarios. SETTING: In vitro study. METHODS: In water, temperature was recorded continuously on the sleeve in an artificial chamber, and ...Cataracts; Wound Burns; Thermal Characteristics2006-02
102 Zhang, KangExpression of wild type and mutant ELOVL4 in cell culture: subcellular localization and cell viabilityPURPOSE: ELOVL4 is a member of the fatty acid elongase (ELO) family of genes. Mutations of this gene are responsible for autosomal dominant Stargardt-like macular degeneration. However, the specific role of ELOVL4 in photoreceptor cells and the mechanism by which mutations in ELOVL4 causes macular d...Endoplasmic Reticulum; Green Fluorescent Proteins; Microscopy, Fluorescence2004
103 Baehr, WolfgangCharacterization of bovine rod outer segment G-proteinA simple modified procedure is described for isolating and purifying peripherally bound membrane proteins from bovine rod outer segment disks. The methods yield milligram quantities of G-protein and cGMP phosphodiesterase which are suitable for reconstitution with membranes containing visual pi...Heterotrimeric GTP-Binding Proteins; Macromolecular Substances; Rhodopsin1982
104 Baehr, WolfgangAnnotation and analysis of 10,000 expressed sequence tags from 3 mouse eye cDNA librariesBACKGROUND: As a biomarker of cellular activities, the transcriptome of a specific tissue or cell type during development and disease is of great biomedical interest. We have generated and analyzed 10,000 expressed sequence tags (ESTs) from three mouse eye tissue cDNA libraries: embryonic day 15.5 (...Cluster Analysis; DNA, Complementary; Gene Expression Profiling2003
105 Jones, Bryan W.Molecular phenotyping of retinal ganglion cellsClassifying all of the ganglion cells in the mammalian retina has long been a goal of anatomists, physiologists, and cell biologists. The rabbit retinal ganglion cell layer was phenotyped using intrinsic small molecule signals (aspartate, glutamate, glycine, glutamine, GABA, and taurine) and glutama...Aspartic Acid/metabolism; Image Cytometry/methods2002
106 Kriesel, John D.; Gooch, Willis M.; Pavia, Andrew T.Invasive sinonasal disease due to Scopulariopsis candida: case report and review of scopulariopsosis.Sinonasal infection with fungi of the order Mucorales--termed mucormycosis or zygomycosis--is sometimes seen in immunosuppressed patients, including those with diabetic ketoacidosis and malignancy. We describe a case of invasive sinonasal infection with Scopulariopsis candida (not among the Mucorale...Granulocyte Colony-Stimulating Factor; Itraconazole; Maxillary Sinus1994
107 Kriesel, John D.; Spruance, Spotswood L.Treatment of herpes simplex labialis.Recurrent herpes simplex labialis is associated with mild morbidity, but remains a significant problem for people with frequent and/or severe recurrences. Both topical and peroral episodic antiviral treatments of recurrences are modestly effective at reducing the duration of signs and symptoms. Rece...Randomized Controlled Trials; Steroids; Drug Administration Routes2002
108 Baehr, WolfgangExpression and mutagenesis of mouse rod photoreceptor cGMP phosphodiesteraseUsing recombinant baculovirus vectors, the three subunits of mouse rod photoreceptor cGMP phosphodiesterase (PDE) (alpha beta gamma 2) have been expressed in insect cells. The recombinant alpha,beta subunits accumulate to 5 mg/liter culture, but most (98%) of the expressed polypeptides are insoluble...Electrophoresis, Polyacrylamide Gel; Macromolecular Substances; Protein Processing, Post-Translational1994
109 Bernstein, Paul S.Human retinal pigment epithelial cell line that retains epithelial characteristics after prolonged culturePURPOSE. A spontaneously arising, apparently transformed, cell line has been cloned from a primary culture of human retinal pigment epithelial (RPE) cells and has been subcultured more than 200 times. The similarities of these cells to human RPE cells in vivo have been determined. METHODS. The struc...Cell Line, Transformed; Chromatography, High Pressure Liquid; Phagocytosis1995
110 Digre, Kathleen B.Selective MR imaging approach for evaluation of patients with Horner's syndrome.PURPOSE: To assess the usefulness of MR in the evaluation of patients with Horner's syndrome. PATIENTS AND METHODS: We prospectively performed MR imaging in 33 patients with Horner's syndrome (13 preganglionic and 20 postganglionic) using a protocol specifically designed for pre- and postganglionic ...Horner Syndrome; Magnetic Resonance Imaging; Epidemiology1992-01
111 Baehr, WolfgangBilateral retinal and brain tumors in transgenic mice expressing simian virus 40 large T antigen under control of the human interphotoreceptor retinoid-binding protein promoterWe have previously shown that postnatal expression of the viral oncoprotein SV40 T antigen in rod photoreceptors (transgene MOT1), at a time when retinal cells have withdrawn from the mitotic cycle, leads to photoreceptor cell death (Al-Ubaidi et al., 1992. Proc. Natl. Acad. Sci. USA. 89:1194-1198)....Simian virus 40; Retinol-Binding Proteins; Promoter Regions (Genetics)1992
112 Baehr, WolfgangMouse opsin. Gene structure and molecular basis of multiple transcriptsThe single copy mouse opsin gene produces five major transcripts, varying in size from 1.7 to 5.1 kilobases. The mRNAs are present at levels that vary over 2 orders of magnitude and can be detected as early as postnatal day 1. Each of the transcripts is polyadenylated and can be identified in polyso...Polyribosomes; Restriction Mapping; Sequence Homology, Nucleic Acid1990
113 Baehr, Wolfgang; Zhang, KangCharacterization of human GRK7 as a potential cone opsin kinasePURPOSE: Homozygous inactivation of the mouse gene for GRK1 (G protein-coupled receptor kinase 1, or rhodopsin kinase) causes severe defects in the recovery of cone phototransduction. However, electroretinographic (ERG) analyses of human oguchi patients with defective GRK1 alleles showed normal or s...Amino Acid Sequence; Chromosomes, Human, Pair 3; Fluorescent Antibody Technique, Indirect2001
114 Normann, Richard A.; Maynard, Edwin M.Neuronal interactions improve cortical population coding of movement directionInteractions among groups of neurons in primary motor cortex (MI) may convey information about motor behavior. We investigated the information carried by interactions in MI of macaque monkeys using a novel multielectrode array to record simultaneously from 12-16 neurons during an arm-reaching task. ...Motor Cortex; Monkey; Population Coding; Movement1999
115 Normann, Richard A.Effects of background illumination on the photoresponses of red and green cones1. The photoresponses of light- and dark-adapted red and green cone photoreceptors were recorded intracellularly in the retina of the turtle, Pseduemys scripta elegans. Background illumination produced similar effects on both types of cones. 2. In response to the onset of a prolonged, steady backgro...Turtles; Adaptation, Ocular; Retina; Signal Transmission1979
116 Kriesel, John D.; Baringer, J R; Spruance, Spotswood L.Correlation between detection of herpes simplex virus in oral secretions by PCR and susceptibility to experimental UV radiation-induced herpes labialis.We examined the oral secretions of 25 patients for herpes simplex virus (HSV) at the time of and following experimental UV radiation (UVR). HSV was detected in one or more oral secretion specimens in 5 of 12 (42%) cases by cell culture and in 8 of 12 (67%) cases by PCR. On the day of UVR, HSV was de...Polymerase Chain Reaction; Ultraviolet Rays; Simplexvirus1994
117 Olson, Randall J.; Crandall, Alan S.; Mamalis, NickIntraoperative miotics and posterior capsular opacification following phacoemulsification with intraocular lens insertionBACKGROUND AND OBJECTIVES: Posterior capsular opacification (PCO) is a frequent complication following phacoemulsification with intraocular lens (IOL) implantation. A series of consecutive patients receiving capsular bag-fixated, silicone IOL implants were assessed for both incidence of PCO and the ...Intraocular Lens; Nd:YAG Laser Capsulotomy; Miochol; Miostat; Phacoemulsification; Posterior Capsular Opacification1997-11
118 Zhang, KangLoss of ER retention and sequestration of the wild-type ELOVL4 by Stargardt disease dominant negative mutantsPURPOSE: Mutations in ELOVL4, a member of the fatty acid elongase (ELO) family, are responsible for autosomal dominant Stargardt-like macular degeneration. The specific role of ELOVL4 in photoreceptors and the degenerative events induced by dominant ELOVL4 mutations are not well understood. As a fir...Macular Degeneration; Transcription Factor CHOP; Molecular Chaperones2005
119 Normann, Richard A.; Horch, Kenneth W.; Cha, KichulMobility performance with a pixelized vision systemA visual prosthesis, based on electrical stimulation of the visual cortex, has been suggested as a means for partially restoring functional vision in the blind. The prosthesis would create a pixelized visual sense consisting of punctate spots of light (phosphenes). The present study investigated the...Visual Prosthesis; Mobility; Phosphene Simulator1992
120 Olson, Randall J.; Coldwell, Karin D.; Compton, Bruce J.; Giddings, John C.Sedimentation field-flow fractionation: a method for studying particulates in cataractous lensIt is shown that the technique of sedimentation field-flow fractionation (sedimentation [sed] FFF) can be used to determine the particle content and particle size distribution of normal and cataractous lenses. A 31-year-old normal human lens, for example, showed a particle content of 1.5% by weight ...Fractionation; Cataractous Lens; Particulates1984
121 Angelucci, AlessandraRole for nitric oxide in the development of the ferret retinogeniculate projectionThe ferret retinogeniculate projection segregates into eye-specific layers during the first postnatal week and into ON/OFF sublaminae, which receive inputs from either on-center or off-center retinal ganglion cells, during the third and fourth postnatal weeks. The restriction of retinogeniculate axo...Enzyme Inhibitors; Visual Pathways; Wheat Germ Agglutinin-Horseradish Peroxidase Conjugate1996
122 Normann, Richard A.; Shah, Maulik R.Study of printed spiral coils for neuroprosthetic transcranial telemetry applicationsWe have explored the use of printed spiral coils (PSC's) for neuroprosthetic transcranial telemetry applications. We fabricated two-dimensional PSC's on a thin (25 microns) polyimide substrate using copper (35 microns) as a conducting material. All the coils had a fixed inner diameter of 1.0 cm. We ...Blindness; Neuroprosthesis; Transcranial Telemetry System; Prosthesis Design1998
123 Bernstein, Paul S.Evaluation of the G protein coupled receptor-75 (GPR75) in age related macular degeneration2001
124 Bernstein, Paul S.Biochemical characterization of the retinoid isomerase system of the eyeWe have previously shown that membranes from the retinal pigment epithelium can transform added all-trans-retinol into a mixture of 11-cis-retinoids, demonstrating the "missing reaction" in the visual cycle for the first time (Bernstein, P. S., Law, W. C., and Rando, R. R. (1987) Proc. Natl. Acad. S...Hydrogen-Ion Concentration1987
125 Olson, Randall J.Update on a long-term, prospective study of capsulotomy and retinal detachment rates after cataract surgeryPURPOSE: To evaluate the retinal detachment risks and neodymium:YAG (Nd:YAG) capsulotomy rates associated with different cataract approaches and intraocular lens (IOL) styles in a long-term,prospective clinical study. SETTING: Clinical practice of 1 ophthalmologist, Fort Collins, Colorado, USA. METH...Cataract Extraction; Laser Therapy; Retinal Detachment; Risk Factors2000-07
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