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CreatorTitleDescriptionSubjectDate
101 Beckerle, Mary C.Comparison of three members of the cysteine-rich protein family reveals functional conservation and divergent patterns of gene expressionMembers of the cysteine-rich protein (CRP) family are evolutionarily conserved proteins that have been implicated in the processes of cell proliferation and differentiation. In particular, one CRP family member has been shown to be an essential regulator of cardiac and skeletal muscle development.LIM domains; Chicken fibroblasts; Zyxin; Actinin; Protein expression; Cysteine-rich proteins1997
102 Davidson, Diane W.Competition and the structure of granivore communitiesWe trace the development of our investigations of granivory in desert ecosystems, illustrating the synthesis of the comparative and experimental approaches and noting the essential contributions of both. In the process, we also call attention to several major difficulties inherent to experimentatio...Granivory; Competition; Desert Ecosystems; Competitive investigations; Experimental investigations1980
103 Olivera, Baldomero M.; Parks, Thomas N.Conantokin-T: a γ-carboxyglutamate containing peptide with N-methyl-D-aspartate antagonist activityConantokin-T, a 21-amino acid peptide which induces sleep-like symptoms in young mice was purified from the venom of the fish-hunting cone snail, Conus tulipa. The amino acid sequence of the peptide was determined and verified by chemical synthesis. The peptide has 4 residues of the modified amino ...Conotoxins; Conantokin-T; N-methyl-D-aspartate antagonist; Conus tulipa1990
104 Seger, JonConditional relatedness, recombination, and the chromosome numbers of insectsIf two polymorphic loci are out of phase equilibrium, a homozygote at one of these loci is more highly related to its kin, at the other locus, than is an equivalent heterozygote. As a result, selection can favor (1) phenotypic responses to relative heterozygosity, and (2) increased recombination bet...Coefficients of relatedness; Conditional relatedness1983
105 Olivera, Baldomero M.Conodipine-M, a novel phospholipase A2 isolated from the venom of the marine snail Conus magusWe describe the purification and first biochemical characterization of an enzymatic activity in venom from the marine snail Conus magus. This enzyme, named conodipine-M, is a novel phospholipase A2 with a molecular mass of 13.6 ĸDa and is comprised of two polypeptide chains linked by one or more di...Conotoxins; Conodipine-M; Conus magus1994
106 Olivera, Baldomero M.; Gray, William RobertConotoxin MI: disulfide bonding and conformational statesThe toxic peptide from Conus magus venom (conotoxin MI) is a 14-amino acid peptide (McIntosh, M., Cruz, L. J., Hunkapiller, M. W., Gray, W. R., and Olivera, B. M. (1982) Arch. Biochem. Biophys. 218, 329-334) which inhibits the acetylcholine ceptor. In this work we have confirmed the primary structu...Conotoxins; Disulfide bonding; Venom; Conus magus1983
107 Olivera, Baldomero M.; Hillyard, David R.ConotoxinsMany successful animal and plant families have developed distinctive biochemical strategies; one of the more unusual examples is found in a group of marine gastropods, the cone snails (Conus) (1). These animals have evolved a specialized biochemistry of small constrained peptides, the conotoxins. Th...Conotoxins1991
108 Potts, Wayne K.Consequences of self and foreign superantigen interaction with specific VB elements of the murine TCR aBThe aB T-cell receptor (TCRaB) recognizes a ligand composed of an antigen fragment complexed with a product of the major histocompatibility complex (MHC). The repertoire of receptors is limited both by the germ line of receptor variable elements and by selective events that take place during T-cell ...Toxins; Repertoire; Expression1989
109 Beckerle, Mary C.; Clark, Kathleen A.Conserved LIM protein that affects muscular adherens junction integrity and mechanosensory function in Caenorhabditis elegansWe describe here the molecular and functional characterization of the Caenorhabditis elegans unc-97 gene, whose gene product constitutes a novel component of muscular adherens junctions. UNC-97 and homologues from several other species define the PINCH family, a family of LIM proteins whose modula...LIM domains; Caenorhabditis elegans; UNC-97; Adherens junction; Touch neuron; Muscle development1999
110 Adler, Frederick R.Construction of multidimensional clustered patternsEcological processes often depend upon the patterning, as well as the absolute density, of resources. In this paper, we develop methods for describing pattern from the perspective of the organism encountering and exploiting the resources, and for reconstructing pattern from the description.Algorithms; clustered resources; foraging1994
111 Goller, FranzContributions of expiratory muscles to song production in zebra finchesBirdsong production requires coordinated activity of syringeal and respiratory muscles, Phonation occurs during the expiratory phase of the respiratory cycle, and expiratory muscles generate the pressure head for sound production.Phonation; Syringeal muscles; Air sac pressure1999
112 Olivera, Baldomero M.; Gray, William RobertContryphan is a D-tryptophan-containing Conus peptideIn this report, we document for the first time the occurrence of D-tryptophan in a normally translated polypeptide, contryphan. The peptide, isolated from the venom of the fish-hunting marine snail Conus radiatus, produces the "stiff-tail" syndrome in mice.Conotoxins; Contryphan; D-tryptophan; Conus peptides; Conus radiatus; Stiff-tail syndrome1996
113 Olivera, Baldomero M.; Gray, William Robert; Yoshikami, DojuConus geographus toxins that discriminate between neuronal and muscle sodium channelsWe describe the properties of a family of 22-amino acid peptides, the μ-conotoxins, which are useful probes for investigating voltage-dependent sodium channels of excitable tissues. The μ-conotoxins are present in the venom of the piscivorous marine snail, Conus geographus L. We have purified even...Conus geographus; Venom; Conotoxins; Sodium channels; Neurotoxins1985
114 Olivera, Baldomero M.; McIntosh, J. MichaelConus peptides as tools for the neuroscientistRecombinant DNA technology has had a powerful impact on understanding receptors and ion channels, the key components in the nervous system that are involved in intercellular communication. Cloning genes encoding these proteins has revealed that for every receptor and ion channel type, multiple molec...Conus peptides; Conotoxins1993
115 Olivera, Baldomero M.Conus peptides: biodiversity-based discovery and exogenomicsThe venoms of the ~700 species of predatory cone snails (genus Conus) are being systematically characterized. Each Conus species contains 100-200 small, highly structured venom peptides (colloquially known as conotoxins), which are synthesized and secreted in a venom duct (for overviews, see Refs. ...Conotoxins; Conus peptides; Exogenomics2006
116 Olivera, Baldomero M.Conus peptides: phylogenetic range of biological activityThe major function of the venoms of the predatory marine snails belonging to the genus Conus is to paralyze prey. Thus, the venom of each Conus species acts on receptors and ion channels of the prey; previous studies suggested much less activity on homologous receptor targets in more distant taxa....Conus peptides; Conopeptides; Conotoxins1992
117 Olivera, Baldomero M.Conus venom peptides, receptor and ion channel targets, and drug design: 50 million years of neuropharmacologyThe predatory cone snails (Conus) are among the most successful living marine animals (~500 living species). Each Conus species is a specialist in neuropharmacology, and uses venom to capture prey, to escape from and defend against predators and possibly to deter competitors. An individual cone...Conotoxins1997
118 Goller, FranzCoordination and synergism between visual and vocal display in the brown-headed cowbirdsSexually selected acoustic signaling is accompanied by visual displays in many birds. The motor integration of visual and vocal displays has not been extensively studied. Brown-headed cowbirds (Molothrus ater) "puff up" prior to song, move their wings during the song and conclude with a bow. The ...Acoustic signaling; Wing display; Synergistic interaction2003
119 Sekercioglu, CaganCorrelates of elevational specialisation in Southeast Asian tropical birdsThe understanding of elevational selectivity in extremely rich tropical biotas is critical to the study of accelerating human-mediated environmental changes (e.g., deforestation and global climate warming). This paper explores the characteristics of Southeast Asian birds that are altitudinal special...2012-01-01
120 Carrier, David R.Coupled evolution of breathing and locomotion as a game of leapfrogBecause the increase in metabolic rate related to locomotor activity places demands on the cardiorespiratory apparatus, it is not surprising that the evolution of breathing and of locomotion are coupled. As the respiratory faculty becomes more refined, increasingly aerobic life strategies can be exp...Evolution; Coupled evolution; Breathing; Locomotion; Cardiorespiratory apparatus2006
121 Capecchi, Mario R.Creating mice with targeted disruptions in protooncogenes and homeobox genes, NIH Director's Lecture given May 21, 1992This is an audio transcript of a 1 hour, 2 minutes and 12 seconds lecture given at the National Institutes of Health by Mario Capecchi on 1992/05/21. Beginning with a short summary of the mechanics of gene transfer and the ability to create germline chimera with mutations that become hereditary wit...Transgenic mice; Gene targeting; Genetic engineering; Molecular genetics; Mutagenesis; Homeobox genes; Histology - Pathological; Gene expression; Gene regulation; Genotype; Phenotype1992
122 Capecchi, Mario R.Critical role of tissue angiotensin-converting enzyme as revealed by gene targeting in miceAngiotensin-converting enzyme (ACE) generates the vasoconstrictor angiotensin II, which plays a critical role in maintenance of blood pressure in mammals. Although significant ACE activity is found in plasma, the majority of the enzyme is bound to tissues such as the vascular endothelium. We used ta...Blood pressure; ACE activity; Enzyme1997-03-06
123 Bohs, Lynn A.Crossing studies in Cyphomandra (Solanaceae) and their systematic and evolutionary significanceA crossing program involving eight species of Cyphomandra was instituted to elucidate systematic relationships between the taxa and evolutionary mechanisms operating in the genus. The results show that gametophytic self-incompatibility is widespread in Cyphomandra. Pollen tubes were able to reach ...Solanum maternum; Crossing studies1991
124 Beckerle, Mary C.CRP1, a LIM domain protein implicated in muscle differentiation, interacts with α-actininMembers of the cysteine-rich protein (CRP) family are LIM domain proteins that have been implicated in muscle differentiation. One strategy for defining the mechanism by which CRPs potentiate myogenesis is to characterize the repertoire of CRP binding partners.CRP1; Cysteine-rich proteins; Actinin; Protein-protein interactions; LIM domains1997
125 Gesteland, Raymond F.; Krapcho, Karen J.; Talbot, Phil; Thulin, CraigCrystallization of the MS2 translational repressor alone and complexed to bromouridineThe coat protein from the MS2 bacteriophage plays a dual role by encapsidating viral RNA and also by binding RNA as a translational repressor. In order to study the isolated dimer in a conformation not influenced by capsid interactions, a mutant molecule was crystallized that is defective in capsid ...Crystallization; RNA Bacteriophage; RNA Hairpin; Translational Repressor1995
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