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CreatorTitleDescriptionSubjectDate
76 Digre, Kathleen B.; Skuster, Denise Z.Neurologic conditions presenting as psychiatric disorders.Understanding underlying neuroanatomic function helps physicians to localize defects and search for treatable neurologic conditions. Neurologic conditions such as Huntington's chorea, Wilson's disease, Gille de la Tourette syndrome, brain tumors, encephalitis and meningitis, neurodegenerative condit...Psychiatric Diagnosis; Neurologic Disease1992-06-15
77 Kriesel, John D.Miliary Tuberculosis and the postpartum stateIn 1985, a resurgence of tuberculosis began in the United States. In conjunction with this resurgence, there has been an increase in the number of atypical presentations of the disease. We recently treated a patient who had disseminated tuberculosis that became manifest in the postpartum state. Wher...Miliary tuberculosis; Postpartum1995
78 Olson, Randall J.Comparison of the effects of viscoelastic agents on clinical properties of the Unfolder lens injection systemPURPOSE: To evaluate the effect of 7 viscoelastic materials on the physical properties of the Unfolder lens injection system. SETTING: John A. Moran Eye Center, University of Utah School of Medicine, Salt Lake City, Utah, USA. METHODS: New sterile SI-40NB intraocular lenses (IOLs) were loaded into t...Lenses, Intraocular; Materials Testing; Hyaluronic Acid; Equipment Failure Analysis1999-07
79 Normann, Richard A.; Maynard, Edwin M.Neuronal interactions improve cortical population coding of movement directionInteractions among groups of neurons in primary motor cortex (MI) may convey information about motor behavior. We investigated the information carried by interactions in MI of macaque monkeys using a novel multielectrode array to record simultaneously from 12-16 neurons during an arm-reaching task. ...Motor Cortex; Monkey; Population Coding; Movement1999
80 Normann, Richard A.Effects of background illumination on the photoresponses of red and green cones1. The photoresponses of light- and dark-adapted red and green cone photoreceptors were recorded intracellularly in the retina of the turtle, Pseduemys scripta elegans. Background illumination produced similar effects on both types of cones. 2. In response to the onset of a prolonged, steady backgro...Turtles; Adaptation, Ocular; Retina; Signal Transmission1979
81 Kriesel, John D.; Baringer, J R; Spruance, Spotswood L.Correlation between detection of herpes simplex virus in oral secretions by PCR and susceptibility to experimental UV radiation-induced herpes labialis.We examined the oral secretions of 25 patients for herpes simplex virus (HSV) at the time of and following experimental UV radiation (UVR). HSV was detected in one or more oral secretion specimens in 5 of 12 (42%) cases by cell culture and in 8 of 12 (67%) cases by PCR. On the day of UVR, HSV was de...Polymerase Chain Reaction; Ultraviolet Rays; Simplexvirus1994
82 Bernstein, Paul S.Identification of lutein and zeaxanthin oxidation products in human and monkey retinasPURPOSE: To characterize fully all the major and minor carotenoids and their metabolites in human retina and probe for the presence of the oxidative metabolites of lutein and zeaxanthin. METHODS: Carotenoids of a composite of 58 pairs of human retinas and a monkey retina were elucidated by comparing...Mass Spectrometry; Oxidation-Reduction; Spectrophotometry, Ultraviolet1997
83 Olson, Randall J.; Spencer, Terrence S.; Mamalis, NickThree-year clinical comparison of 3-piece AcrySof and SI-40 silicone intraocular lensesPURPOSE: To compare the 3-year performance of the 3-piece AcrySof (Alcon) and the SI-40 silicone (Allergan) intraocular lenses (IOLs). SETTING: John A. Moran Eye Center, University of Utah, Salt Lake City, Utah, USA. METHODS: In this retrospective study, patients with no complications and at least a...Acrylic Resins; Silicone Elastomers; Prosthesis Design; Postoperative Complications; Patient Satisfaction; Cataract2002-07
84 Levine, Edward M.Sonic hedgehog promotes rod photoreceptor differentiation in mammalian retinal cells in vitro.The hedgehog gene family encodes secreted proteins important in many developmental patterning events in both vertebrates and invertebrates. In the Drosophila eye disk, hedgehog controls the progression of photoreceptor differentiation in the morphogenetic furrow. To investigate whether hedgehog prot...Sonic hedgehog; Indian hedgehog; Desert hedgehog; Retina; Mitogenesis; Differentiation; Rod Photoreceptor1997-08-15
85 Baehr, WolfgangCharacterization of bovine rod outer segment G-proteinA simple modified procedure is described for isolating and purifying peripherally bound membrane proteins from bovine rod outer segment disks. The methods yield milligram quantities of G-protein and cGMP phosphodiesterase which are suitable for reconstitution with membranes containing visual pi...Heterotrimeric GTP-Binding Proteins; Macromolecular Substances; Rhodopsin1982
86 Baehr, WolfgangAnnotation and analysis of 10,000 expressed sequence tags from 3 mouse eye cDNA librariesBACKGROUND: As a biomarker of cellular activities, the transcriptome of a specific tissue or cell type during development and disease is of great biomedical interest. We have generated and analyzed 10,000 expressed sequence tags (ESTs) from three mouse eye tissue cDNA libraries: embryonic day 15.5 (...Cluster Analysis; DNA, Complementary; Gene Expression Profiling2003
87 Jones, Bryan W.Molecular phenotyping of retinal ganglion cellsClassifying all of the ganglion cells in the mammalian retina has long been a goal of anatomists, physiologists, and cell biologists. The rabbit retinal ganglion cell layer was phenotyped using intrinsic small molecule signals (aspartate, glutamate, glycine, glutamine, GABA, and taurine) and glutama...Aspartic Acid/metabolism; Image Cytometry/methods2002
88 Kriesel, John D.; Gooch, Willis M.; Pavia, Andrew T.Invasive sinonasal disease due to Scopulariopsis candida: case report and review of scopulariopsosis.Sinonasal infection with fungi of the order Mucorales--termed mucormycosis or zygomycosis--is sometimes seen in immunosuppressed patients, including those with diabetic ketoacidosis and malignancy. We describe a case of invasive sinonasal infection with Scopulariopsis candida (not among the Mucorale...Granulocyte Colony-Stimulating Factor; Itraconazole; Maxillary Sinus1994
89 Kriesel, John D.; Spruance, Spotswood L.Treatment of herpes simplex labialis.Recurrent herpes simplex labialis is associated with mild morbidity, but remains a significant problem for people with frequent and/or severe recurrences. Both topical and peroral episodic antiviral treatments of recurrences are modestly effective at reducing the duration of signs and symptoms. Rece...Randomized Controlled Trials; Steroids; Drug Administration Routes2002
90 Baehr, WolfgangExpression and mutagenesis of mouse rod photoreceptor cGMP phosphodiesteraseUsing recombinant baculovirus vectors, the three subunits of mouse rod photoreceptor cGMP phosphodiesterase (PDE) (alpha beta gamma 2) have been expressed in insect cells. The recombinant alpha,beta subunits accumulate to 5 mg/liter culture, but most (98%) of the expressed polypeptides are insoluble...Electrophoresis, Polyacrylamide Gel; Macromolecular Substances; Protein Processing, Post-Translational1994
91 Larson, Scott A.Strabismus surgery complications: prevention and managementStrabismus surgery is increasingly becoming a subspecialty domain, especially with cyclovertical muscles, restricted muscles, or reoperations. While is impossible to completely eliminate complications from strabimus surgery, it is possible to minimize their occurrence and significance by proper prev...Malignant hyperthermia; Overcorrection; Strabismus; Surgery; Undercorrection2003
92 Baehr, Wolfgang; Thulin, CraigImmunolocalization and divergent roles of phosducin and phosducin-like protein in the retinaPURPOSE: These investigations were undertaken to compare and contrast the roles of phosducin and phosducin-like protein in the retina. METHODS: Phosducin and phosducin-like protein were compared in an in vitro assay measuring their inhibition of transducin binding to light-activated rhodopsin. The t...Antibody Specificity; Protein Binding; Rod Outer Segments1999
93 Olson, Randall J.Glistenings with long-term follow-up of the Surgidev B20/20 polymethylmethacrylate intraocular lensPURPOSE: To compare patient satisfaction with vision 12 months after implantation of a silicone or acrylic foldable intraocular lens (IOL). SETTING: John A. Moran Eye Center, University of Utah Medical Center, Salt Lake City, Utah, USA. METHODS: Selection criteria included patients who had uneventfu...Phacoemulsification; Lens Implantation, Intraocular; Glare2001-10
94 Baehr, WolfgangMetabolism and transactivation activity of 13,14-dihydroretinoic acidThe metabolism of vitamin A is a highly regulated process that generates essential mediators involved in the development, cellular differentiation, immunity, and vision of vertebrates. Retinol saturase converts all-trans-retinol to all-trans-13,14-dihydroretinol (Moise, A. R., Kuksa, V., Imanishi, Y...Chromatography, High Pressure Liquid; Electrophoresis, Polyacrylamide Gel; Retinoid X Receptors2005
95 Zhang, KangNew locus for autosomal dominant stargardt-like disease maps to chromosome 4Stargardt disease (STGD) is the most common hereditary macular dystrophy and is characterized by decreased central vision, atrophy of the macula and underlying retinal-pigment epithelium, and frequent presence of prominent flecks in the posterior pole of the retina. STGD is most commonly inherited a...Haplotypes; Genetic Markers1999
96 Normann, Richard A.; Branner, AlmutLong-term stimulation and recording with a penetrating microelectrode array in cat sciatic nerveWe studied the consequences of long-term implantation of a penetrating microelectrode array in peripheral nerve over the time course of 4-6 mo. Electrode arrays without lead wires were implanted to test the ability of different containment systems to protect the array and nerve during contractions o...Cats; Microelectrodes; Prosthesis Implantation; Sciatic Nerve2004
97 Bernstein, Paul S.; Zabriskie, Norman A.; Zhang, KangCFH Y402H Confers similar risk of soft Drusen and both forms of advanced AMDBACKGROUND: Age-related macular degeneration (AMD) is the most common cause of irreversible visual impairment in the developed world. The two forms of advanced AMD, geographic atrophy and neovascular AMD, represent different pathological processes in the macula that lead to loss of central vision. S...2005
98 Normann, Richard A.; Clark, Gregory A.; McDonnall, DanielSelective motor unit recruitment via intrafascicular multielectrode stimulationRecruitment of force via independent asynchronous firing of large numbers of motor units produces the grace and endurance of physiological motion. We have investigated the possibility of reproducing this physiological recruitment strategy by determining the selectivity of access to large numbers of ...Funtional Neuromuscular Stimulation; Microelectrode Array; Neuroprosthesis; Intrafascicular Multielectrode Stimulation; Cats2004
99 Baehr, WolfgangCharacterization of the chicken GCAP gene array and analyses of GCAP1, GCAP2, and GC1 gene expression in normal and rd chicken pinealPURPOSE: This study had three objectives: (1) to characterize the structures of the chicken GCAP1 and GCAP2 genes; (2) to determine if GCAP1, GCAP2, and GC1 genes are expressed in chicken pineal gland; (3) if GC1 is expressed in chicken pineal, to determine if the GC1 null mutation carried by the re...Molecular Sequence Data; Promoter Regions (Genetics); Retinal Degeneration1999
100 Digre, Kathleen B.; Schmidt, Richard H.; Osborne, Anne G.; Patel, Bhupendra C.; Pratt, David; Rietz, Lisa A.Compressive optic neuropathy caused by renal osteodystrophy. Case report.Compressive optic neuropathy with acute or chronic vision loss has been associated with various skull base tumors, aneurysms, Graves disease, trauma, and, less commonly, fibrous dysplasia and osteopetrosis. The Author's present a case of acute visual deterioration in a 25-year-old woman who had mass...Optic Neuropathy; Optic Nerve Decompression; Renal Osteodystrophy2001-10
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