NOVEL - Alfredo A. Sadun Collection
 
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51 Cushing and OphthalmologyFrom a lecture at Yale in 2006, reviewing the life of Harvey Cushing, the founder of neurosurgery. Anatomy: Optic chiasm; Optic nerve. Disease/Diagnosis: Pituitary adenoma; Papilledema; X-linked hydrocephalus syndrome; Optic nerve glioma; Graves ophthalmopathy; Mucocele; Pituitary apoplexy; Optic ne...Text
52 Leber's Hereditary Optic Neuropathy: New Lessons From a Giant Pedigree in BrazilReport of an international field investigation to rural Brazil to study a cluster of LHON, including its genetic basis; includes several images of optic nerve and optic disk with LHON. Anatomy: Optic nerve; Optic disk; Retinal ganglion cells. Disease/Diagnosis: Optic Atrophy, Hereditary, Leber. Pres...Text
53 Apoptosis in LHON: An ROS ExplanationA slide presentation describing apoptosis in LHON; includes several images of optic nerve and optic disk. Anatomy: Optic nerve; Optic disk; Retinal ganglion cells; Reactive oxygen species. Disease/Diagnosis: Optic Atrophy, Hereditary, Leber.Text
54 Induction of Apoptosis by Mitochondrial Impairment in LHON and Related DiseasesSlide presentation includes six pairs of microscopic slides showing LHON and control examples of optic nerve. Anatomy: Optic nerve. Disease/Diagnosis: Optic Atrophy, Hereditary, Leber.Text
55 The Diagnostic Workup in Patients With Optic Neuropathies (Metodo diagnostico)Slideshow presentation with images of optic disc with edema and "Positive temporal artery biopsy". Presenting Symptom: Hyperopia; Metamorphopsia. Anatomy: Optic nerve; Macula Lutea; Optic disc. Disease/Diagnosis: Optic neuritis; Macular edema; Optic neuropathy, Ischemic.Text
56 Leber's Hereditary Optic Neuropathy: A Very Large New Pedigree in BrazilReport of an international field investigation to rural Brazil to study a cluster of LHON, including its genetic basis. Includes several images of optic nerve and optic disk with LHON. Anatomy: Optic nerve; Optic disk. Disease/Diagnosis: Optic Atrophy, Hereditary, Leber. Presenting Symptom: Blindnes...Text
57 The Clinical Spectrum of Amiodarone-Associated Optic NeuropathySadun's response to a paper by L.N. Johnson, G.B. Kroheld, and E.R. Thomas at 2004 AAO meeting. Anatomy: Optic nerve. Disease/Diagnosis: Optic nerve diseases; Optic neuropathy, IschemicText
58 Subclinical Visual Abnormalities in Carriers With 11778 LHON from a 300 Member Brazilian PedigreeReport of a multi-year international field investigation to rural Brazil to study a cluster of LHON, including its genetic roots. Presenting Symptom: Scotoma; Telangiectasis; Blindness. Anatomy: Optic nerve; Optic disk; Retinal ganglion cells; Reactive oxygen species. Pathology: Slides showing LHON ...Text
59 Mitochondrial Optic Neuropathies (MON)Combination of two presentations on optic nerve diseases, covering the cases in Cuba and Brazil. Titles: Cuban epidemic of optic neuopathy: even zealots must eat, or, Conversations with Castro and Leber's hereditary optic neuropathy: a very large new pedigree in Brazil; includes several images of ...Text
60 Beyond the Margulis Hypothesis: The Time Bomb Within UsPresented at Harvard, 2005; includes several images of optic disc with LHON. Anatomy: Optic nerve; Optic disk; Retinal ganglion cells; Reactive oxygen species. Disease/Diagnosis: Optic Atrophy, Hereditary, Leber. Presenting Symptom: Dyschromatopsia; Scotoma.Text
61 Why You Should Prescribe Goggles to a Box JellyfishA discussion of the box jellyfish eye and visual system. Anatomy: Retina; Lens, Crystalline.Text
62 How Strong is the Case for an Association Between PDE5 Inhibitors and NAION?Anatomy: Optic nerve. Disease/Diagnosis: Optic Neuropathy, Ischemic; Toxic optic neuropathy. Presenting Symptom: Ischemia; Scotoma; Dyschromatopsia.Text
63 Beyond the Margulis Hypothesis: The Time Bomb Within UsPresented at 36th Annual Doheny Days, 2005. Anatomy: Optic nerve; Retina; Retinal ganglion cells; Reactive oxygen species. Disease/Diagnosis: Optic Atrophy, Hereditary, Leber.Text
64 AIDS: Neuro-Ophthalmologic ManifestationsDiscusses various neuro-opthalmological complications to which AIDS patients are prone, and results of experimental testing on rabbits using Pentoxifylline. Anatomy: Optic nerve; Axons; Optic disk; Astrocytes; Macrophages. Pathology: Slides showing astrocytes, macrophages, cytokine staining. Disease...Text
65 Acute Retrobulbar Optical NeuropathyPPT covering acute retrobulbar optic neuropathy, including ischemic, inflammatory, anterior ischemic optic neuropathy (AION) and non-arteritic anterior ischemic optic neuropathy (NAION); includes brainscan images for optic neuritis and multiple sclerosis; optic disk with LHON and PION. Anatomy: Opt...Text
66 Leber's Hereditary Optic Neuropathy (LHON) in Brazil: OpportunitiesReport of an international field investigation to rural Brazil to study a cluster of LHON, including its genetic roots. Presented at Allergan, 2006. Includes several images of optic nerve and optic disk with LHON. Anatomy: Optic nerve; Myelin sheath; Optic Disk. Disease/Diagnosis: Optic Atrophy, H...Text
67 A Neuro-Ophthalmologist's View of RGC Apoptosis and NeuroprotectionSlide presentation with several microscopic images demonstrating cell death, LHON, AIDS. Anatomy: Optic nerve; Retina; Retinal ganglion cells; Phosphopyruvate Hydratase; Reactive oxygen species. Disease/Diagnosis: Optic Atrophy, Hereditary, Leber; Acquired Immunodeficiency Syndrome; Glaucoma. Presen...Text
68 Atypical Optic NeuropathiesA discussion of atypical optic neuropathies. Anatomy: Optic nerve; Optic disc. Pathology: Slides showing LHON. Disease/Diagnosis: Optic neuropathy, Ischemic; Optic atrophy, Hereditary, Leber; Toxic optic neuropathy. Presenting Symptom: Optic neuritis; Eye hemorrhage; Retinal vasculitis; Dyschromatop...Text
69 Extremely High Resolution Magnetic Resonance Imaging of the Human Optic Nerve HeadMRI imagery of optic nerves demonstrates ability to identify cases of Leber's Hereditary Optic Neuropathy (LHON); includes MRI images of optic nerves. Anatomy: Optic nerve. Disease/Diagnosis: Optic Atrophy, Hereditary, Leber.Text
70 Leber's Hereditary Optic Neuropathy: New Insights?Several microscopic images of optic nerve with LHON. Anatomy: Optic nerve. Disease/Diagnosis: Optic Atrophy, Hereditary, Leber. Presenting Symptom: Scotoma; Dyschromatopsia.Text
71 Mitochondrial Optic Neuropathy: Mitochondria as Gatekeepers for ApoptosisAnatomy: Optic nerve; Retina; Retinal ganglion cells; Reactive oxygen species. Disease/Diagnosis: Optic Atrophy, Hereditary, Leber; Toxic optic neuropathy. Presenting Symptom: Scotoma; Dyschromatopsia.Text
72 Pentoxifylline Suppression of TNF-Alpha Mediated Axonal Degeneration in the Rabbit Optic NervePresenting Symptom: Dyschromatopsia. Anatomy: Optic nerve. Disease/Diagnosis: Acquired Immunodeficiency Syndrome; Demyelinating autoimmune diseases, CNS. Treatment: Pentoxifylline.Text
73 The Diagnostic Workup in Patients With Optic NeuropathiesSlideshow presentation with images of optic disc with edema and optic atrophy. Presenting Symptom: Telangiectasis; Dyschromatopsia; Scotoma. Anatomy: Optic nerve; Optic disc; Phosphopyruvate Hydratase; Enolase. Disease/Diagnosis: Optic neuritis; Macular edema; Optic neuropathy, Ischemic; Optic atrop...Text
74 Pupils and Fields: The Importance of Assessing the Optic NervePresenting Symptom: Anisocoria; Adie syndrome; Scotoma; Afferent pupillary defect; Horner Syndrome; Edema; Papilledema; Optic nerve; Pupil; Optic disc. Anatomy: Optic nerve; Pupil; Optic disc. Disease/Diagnosis: Afferent pupillary defect; Horner Syndrome; Edema; Papilledema.Text
75 Cuban Epidemic of Optic Neuropathy: Even Zealots Must Eat, or, Conversations with CastroA team of neuro-opthalmologists visits Cuba in 1993 and 1994, and attempts to treat patients with vision disorders. Anatomy: Optic nerve; Structure of cribriform plate. Disease/Diagnosis: Optic nerve diseases; Blindness; Ambliopia; Alcoholic neuropathy. Treatment: Folate. Presenting Symptom: Ataxia;...Text
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