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CreatorTitleDescriptionSubjectDate
51 Angelucci, AlessandraLayer-specific programs of development in neocortical projection neuronsHow are long-range axonal projections from the cerebral cortex orchestrated during development? By using both passively and actively transported axonal tracers in fetal and postnatal ferrets, we have analyzed the development of projections from the cortex to a number of thalamic nuclei. We report th...Axonal Transport; Efferent Pathways; Brain Mapping1995
52 Bernstein, Paul S.Human retinal pigment epithelial cell line that retains epithelial characteristics after prolonged culturePURPOSE. A spontaneously arising, apparently transformed, cell line has been cloned from a primary culture of human retinal pigment epithelial (RPE) cells and has been subcultured more than 200 times. The similarities of these cells to human RPE cells in vivo have been determined. METHODS. The struc...Cell Line, Transformed; Chromatography, High Pressure Liquid; Phagocytosis1995
53 Normann, Richard A.Visual Neuroprosthetics: Functional Vision for the BlindResent progress in materials and microfabrication technologies have allowed researchers to reconsider the prospect of providing a useful visual sense to the profoundly blind. This will be accomplished by electrically stimulating their visual systems via an array of implanted microelectrodes. T...Visual Neuroprosthetics; Vision; Blindness1995-01
54 Angelucci, AlessandraRole for nitric oxide in the development of the ferret retinogeniculate projectionThe ferret retinogeniculate projection segregates into eye-specific layers during the first postnatal week and into ON/OFF sublaminae, which receive inputs from either on-center or off-center retinal ganglion cells, during the third and fourth postnatal weeks. The restriction of retinogeniculate axo...Enzyme Inhibitors; Visual Pathways; Wheat Germ Agglutinin-Horseradish Peroxidase Conjugate1996
55 Baehr, WolfgangTrilateral tumors in four different lines of transgenic mice expressing SV40 T-antigenPURPOSE. A line of transgenic mice containing the simian virus (SV) 40 T-antigen (T-ag) gene driven by the beta-luteinizing hormone (BLH) promoter developed bilateral retinoblastoma and primitive neuroectodermal tumors (PNET) of the midbrain. Midbrain tumors arose from the subependymal layer of the ...Mice, Transgenic; Retinol-Binding Proteins; Eye Proteins1996
56 Kriesel, John D.; Spruance, Spotswood L.; Daynes, Raymond A.Nucleic acid vaccine encoding gD2 protects mice from herpes simplex virus type 2 disease.Nucleic acid vaccinations with plasmids pWW65, containing the sequence for herpes simplex type 2 (HSV-2) gD2, and pRSVnt, lacking the gD sequence, were studied. Groups of mice were immunized with pWW65 alone, pWW65 plus 1,25-dihydroxyvitamin-D3 (D3), or pRSVnt. Clinical disease (vaginitis), serum an...Mice, Inbred BALB C; Plasmids; Viral Vaccines1996
57 Normann, Richard A.; Jones, Kelly E.Advanced demultiplexing system for physiological stimulationA CMOS very large scale integration (VLSI) chip has been designed and built to implement a scheme developed for multiplexing/demultiplexing the signals required to operate an intracortical stimulating electrode array. Because the use of radio telemetry in a proposed system utilizing this chip may im...Electrode Array; Stimulation; Telemetry; Microelectrodes; Transistors1997
58 Bernstein, Paul S.Identification of lutein and zeaxanthin oxidation products in human and monkey retinasPURPOSE: To characterize fully all the major and minor carotenoids and their metabolites in human retina and probe for the presence of the oxidative metabolites of lutein and zeaxanthin. METHODS: Carotenoids of a composite of 58 pairs of human retinas and a monkey retina were elucidated by comparing...Mass Spectrometry; Oxidation-Reduction; Spectrophotometry, Ultraviolet1997
59 Kriesel, John D.; Maulden, Sarah Annamarie; Spruance, Spotswood L.Anti-interleukin-6 antibodies inhibit herpes simplex virus reactivation.Herpes simplex viruses (HSVs) infect epithelial cells, become localized in neurons, and can reactivate in response to a variety of stimuli, including ultraviolet light and hyperthermia. The sequence of gene activation during viral replication is known, but the molecular linkage between exogenous sti...Mice, Inbred BALB C; Tumor Necrosis Factor-alpha; Virus Activation1997
60 Bernstein, Paul S.Retinal tubulin binds macular carotenoidsPURPOSE: To investigate the biochemical mechanisms responsible for the specific uptake, concentration, and stabilization of the carotenoids lutein and zeaxanthin in the macula. METHODS: Soluble extracts of bovine retina mixed with radioactive carotenoids were purified by hydrophobic interaction, ion...Chromatography, Gel; Electrophoresis; Xanthophylls1997
61 Angelucci, AlessandraExperimentally induced retinal projections to the ferret auditory thalamus: development of clustered eye-specific patterns in a novel targetWe have examined the relative role of afferents and targets in pattern formation using a novel preparation, in which retinal projections in ferrets are induced to innervate the medial geniculate nucleus (MGN). We find that retinal projections to the MGN are arranged in scattered clusters. Clusters a...Retina; Ferrets1997
62 Levine, Edward M.Sonic hedgehog promotes rod photoreceptor differentiation in mammalian retinal cells in vitro.The hedgehog gene family encodes secreted proteins important in many developmental patterning events in both vertebrates and invertebrates. In the Drosophila eye disk, hedgehog controls the progression of photoreceptor differentiation in the morphogenetic furrow. To investigate whether hedgehog prot...Sonic hedgehog; Indian hedgehog; Desert hedgehog; Retina; Mitogenesis; Differentiation; Rod Photoreceptor1997-08-15
63 Olson, Randall J.; Crandall, Alan S.; Mamalis, NickIntraoperative miotics and posterior capsular opacification following phacoemulsification with intraocular lens insertionBACKGROUND AND OBJECTIVES: Posterior capsular opacification (PCO) is a frequent complication following phacoemulsification with intraocular lens (IOL) implantation. A series of consecutive patients receiving capsular bag-fixated, silicone IOL implants were assessed for both incidence of PCO and the ...Intraocular Lens; Nd:YAG Laser Capsulotomy; Miochol; Miostat; Phacoemulsification; Posterior Capsular Opacification1997-11
64 Baehr, Wolfgang; Zhang, Kang; Kolb, HelgaGene array and expression of mouse retina guanylate cyclase activating proteins 1 and 2PURPOSE: To identify gene arrangement, chromosomal localization, and expression pattern of mouse guanylate cyclase activating proteins GCAP1 and GCAP2, retina-specific Ca2+-binding proteins, and photoreceptor guanylate cyclase activators. METHODS: The GCAP1 and GCAP2 genes were cloned from genomic l...Molecular Sequence Data; Guanylate Cyclase-Activating Proteins; In Situ Hybridization, Fluorescence1998
65 Baehr, WolfgangCalcium-sensitive particulate guanylyl cyclase as a modulator of cAMP in olfactory receptor neuronsThe second messengers cAMP and inositol-1,4,5-triphosphate have been implicated in olfaction in various species. The odorant-induced cGMP response was investigated using cilia preparations and olfactory primary cultures. Odorants cause a delayed and sustained elevation of cGMP. A component of this c...Calcium-Binding Proteins; Nerve Tissue Proteins; Rats, Sprague-Dawley1998
66 Normann, Richard A.; Shah, Maulik R.Study of printed spiral coils for neuroprosthetic transcranial telemetry applicationsWe have explored the use of printed spiral coils (PSC's) for neuroprosthetic transcranial telemetry applications. We fabricated two-dimensional PSC's on a thin (25 microns) polyimide substrate using copper (35 microns) as a conducting material. All the coils had a fixed inner diameter of 1.0 cm. We ...Blindness; Neuroprosthesis; Transcranial Telemetry System; Prosthesis Design1998
67 Fu, YingbinMechanism of reductive activation of potato tuber ADP-glucose pyrophosphorylase.The potato tuber (Solanum tuberosum L.) ADP-glucose pyrophosphorylase activity is activated by a incubation with ADP-glucose and dithiothreitol or by ATP, glucose- 1-phosphate, Ca2+, and dithiothreitol. The activation was accompanied by the appearance of new sulfhydryl groups as determined with 5, 5...Glucosephosphates; Enzyme Activation; Adenosine Triphosphate1998
68 Bernstein, Paul S.; Gellermann, WernerRaman detection of macular carotenoid pigments in intact human retinaPURPOSE: To develop and test a novel noninvasive optical technique suitable for the objective measurement of macular carotenoid levels in human retina. METHODS: A resonance Raman scattering apparatus was constructed to measure carotenoid levels in flat-mounted human retinas and eyecups and in experi...Rana pipiens; Spectrum Analysis, Raman; Xanthophylls1998
69 Gouw, Launce G.; McKenna, Catherine K.; Digre, Kathleen B.; Placek, Louis J.Analysis of the dynamic mutation in the SCA7 gene shows marked parental effects on CAG repeat transmission.The gene for spinocerebellar ataxia 7 (SCA7) includes a transcribed, translated CAG tract that is expanded in SCA7 patients. We have determined expansions in 73 individuals from 17 SCA7 kindreds and compared them with repeat lengths of 180 unaffected individuals. Subjects with abnormal expansions co...Genetics; Biosynthesis; SCA7 Gene1998-03-07
70 Swallow, Charles E.; Tsuruda, Jay S.; Digre, Kathleen B.; Glaser, Matthew J.; Davidson, H. Christian; Harnsberger, H. RicTerson syndrome: CT evaluation in 12 patients.PURPOSE: Terson syndrome may be overlooked in the acute setting and often requires ophthalmologic intervention to prevent long-term visual loss. In this syndrome, vitreous or retinal hemorrhage results from an abrupt rise in intracranial pressure, leading to retinal venous hypertension and intraocul...Retinal Hemorrhage; Visual Acuity; Vitreous Hemorrhage1998-04
71 Olson, Randall J.; Crandall, Alan S.; Caldwell, Karin D.; Jensen, Michael K.Intraoperative crystallization on the intraocular lens surfacePURPOSE: To report a physician survey, laboratory studies, and clinical observations of intraoperative crystallization on the surface of the intraocular lens (IOL). METHOD: We sent a survey to all ophthalmologists in the states of Wyoming, Idaho, Montana, Utah, and Colorado asking whether crystalliz...Cataract Extraction; Intraoperative Complications; Risk Factors1998-08
72 Normann, Richard A.; Maynard, Edwin M.Neuronal interactions improve cortical population coding of movement directionInteractions among groups of neurons in primary motor cortex (MI) may convey information about motor behavior. We investigated the information carried by interactions in MI of macaque monkeys using a novel multielectrode array to record simultaneously from 12-16 neurons during an arm-reaching task. ...Motor Cortex; Monkey; Population Coding; Movement1999
73 Baehr, Wolfgang; Thulin, CraigImmunolocalization and divergent roles of phosducin and phosducin-like protein in the retinaPURPOSE: These investigations were undertaken to compare and contrast the roles of phosducin and phosducin-like protein in the retina. METHODS: Phosducin and phosducin-like protein were compared in an in vitro assay measuring their inhibition of transducin binding to light-activated rhodopsin. The t...Antibody Specificity; Protein Binding; Rod Outer Segments1999
74 Zhang, KangNew locus for autosomal dominant stargardt-like disease maps to chromosome 4Stargardt disease (STGD) is the most common hereditary macular dystrophy and is characterized by decreased central vision, atrophy of the macula and underlying retinal-pigment epithelium, and frequent presence of prominent flecks in the posterior pole of the retina. STGD is most commonly inherited a...Haplotypes; Genetic Markers1999
75 Baehr, WolfgangCharacterization of the chicken GCAP gene array and analyses of GCAP1, GCAP2, and GC1 gene expression in normal and rd chicken pinealPURPOSE: This study had three objectives: (1) to characterize the structures of the chicken GCAP1 and GCAP2 genes; (2) to determine if GCAP1, GCAP2, and GC1 genes are expressed in chicken pineal gland; (3) if GC1 is expressed in chicken pineal, to determine if the GC1 null mutation carried by the re...Molecular Sequence Data; Promoter Regions (Genetics); Retinal Degeneration1999
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