| | Title | Creator | Description | Subject | Date |
|---|
| 51 |  | Acoustic droplet vaporization, cavitation, and therapeutic properties of copolymer-stabilized perfluorocarbon nanoemulsions | Christensen, Douglas A. | Acoustic and therapeutic properties of Doxorubicin (DOX) and paclitaxel (PTX)-loaded perfluorocarbon nanoemulsions have been investigated in a mouse model of ovarian cancer. The nanoemulsions were stabilized by two biodegradable amphiphilic block copolymers that differed in the structure of the hydr... | Cancer therapy; Targeted drug delivery; Nanobubbles; Ultrasound; Perfluoropentane | 2009 |
| 52 |  | Action potential classification with dual channel intrafascicular electrodes | Horch, Kenneth W. | Using recordings of peripheral nerve activity made with carbon fiber intrafascicular electrodes, we compared the performance of three different recording techniques (single channel, differential, and dual channel) and four different unit classification methods (linear discriminant analysis, temp... | Carbon fiber intrafascicular electrodes; Dual channel recording | 1994 |
| 53 |  | Plasma-etched polymer waveguides for intrachip optical interconnects | Christensen, Douglas A. | Optical intrachip communication offers the potential advantages of high speed and lack of electrical interference. We report on progress made on an interconnect design using GaAs LEDs, polymer waveguides, and photodiodes in a silicon substrate. The polymer waveguides are fabricated in polyimide or p... | Polymer waveguides; Intrachip interconnects; LEDs | 1998 |
| 54 |  | Problem and treatment of DC offsets in FDTD simulations | Christensen, Douglas A.; Furse, Cynthia M. | This paper discusses the causes of and some solutions to the commonly observed problem of dc field offsets in finite-difference time-domain (FDTD) simulations. DC electric and magnetic field offsets are shown to be valid calculated responses of the modeled systems, resulting from interaction betwee... | Finite-difference time-domain method; Direct current offsets; Waveforms | 2000-08 |
| 55 |  | General formulation for connecting sources and passive lumped-circuit elements across multiple 3-D FDTD cells | Christensen, Douglas A. | A previous extension of the finite-difference time-domain (FDTD) method to include lumped-circuit elements is further extended to model lumped-element circuits connected across multiple FDTD cells. This formulation is needed to model many kinds of circuits, like those with a transistor or other ac... | Finite-difference time-domain method; Lumped-element circuit; Dielectric; Microstrip | 1996-02 |
| 56 |  | Fiberoptic laser angioplasty probe with optical steerability | Christensen, Douglas A.; Vincent, G. Michael | We have designed and bench tested an optically steerable fiberoptic probe for use in laser angioplasty. The unique feature of this design is the use of a gradient-index (GRIN) lens attached to the distal end of a seven-fiber bundle. By selecting which fiber of the bundle is illuminated by the source... | Fiberoptic probe; GRIN lens; Steerability | 1990 |
| 57 |  | Finite-difference time-domain modeling and experimental characterization of planar waveguide fluorescence sensors | Christensen, Douglas A. | The finite-difference time-domain method (FDTD) is a powerful numerical technique for solving Maxwell's equations in a discretized space and time grid. Its applications have up to now been in the analysis of electrically large structures in the microwave domain, and the scope of investigations has b... | Finite-difference time-domain method; Planar waveguide | 1992 |
| 58 |  | Biosensor development at the University of Utah | Christensen, Douglas A. | Interest in biosensors has increased rapidly in the past few years due to the many potential advantages of these devices, such as small size, speed of response, and specificity 111. The term "biosensor" in the broad sense describes any device or apparatus which detects biological signals for the pu... | Silicon retina; Photosensing array; CHEMFET; Fluorescence lmmunosensor; Planar waveguide | 1994-07 |
| 59 |  | Bringing an integrative modeling experience to a freshman biomedical engineering course | Christensen, Douglas A. | As an integrating lab experience in our Fundamentals of Bioengineering freshman course, we have included a Major Project that ties together many of the principles of biomechanics and bioelectricity covered in the lecture. It uses the human systemic cardiovascular system as a model. During the first... | Matlab | 2004 |
| 60 |  | Evanescent coupling in a waveguide fluoroimmunosensor | Christensen, Douglas A.; Herron, James N. | A key factor in the analysis of evanescently-coupled optical sensors, such as the planar waveguide immunosensor analyzed here, is the efficiency of coupling between the optical waveguide modes and the fluorescent sources located on the surface of the waveguide. This is an important parameter in dete... | Evanescent coupling; Waveguide; Fluoroimmunosensor | 1992 |
| 61 |  | Experience with the first three years of an accelerated dual-degree program in biomedical engineering | Christensen, Douglas A.; Horch, Kenneth W. | Our Department of Bioengineering has instituted a pilot program aimed at helping a select group of highly qualified students obtain both bachelor's and master's degrees in an accelerated timeframe-approximately four years from the beginning of their university studies. A key element of this progra... | Accelerated; Dual-degrees; Education | 2004 |
| 62 |  | Differential activation of nerve fibers with magnetic stimulation in humans | Horch, Kenneth W. | Earlier observations in our lab had indicated that large, time-varying magnetic fields could elicit action potentials that travel in only one direction in at least some of the myelinated axons in peripheral nerves. The objective of this study was to collect quantitative evidence for magnetically in... | Magnetic stimulation; Peripheral nerve; Electromyographic potential; Somatosensory potential | 2006 |
| 63 |  | Accelerated 4-year bachelors/masters degree program in biomedical engineering | Horch, Kenneth W.; Christensen, Douglas A. | In response to the need for providing advanced engineering education in a shorter time period than is currently possible by traditional curricula, we have created an Accelerated Dual Degree program in biomedical engineering. The purpose of this pilot program is to attract the brightest students, g... | Accelerated; Dual-degrees; Education | 2002 |
| 64 | | Accelerated 4-year bachelors/masters degree program in biomedical engineering | Horch, Kenneth W.; Christensen, Douglas A. | In response to the need for providing advanced engineering education in a shorter time period than is currently possible by traditional curricula, we have created an Accelerated Dual Degree program in biomedical engineering. The purpose of this pilot program is to attract the brightest students, g... | Accelerated dual-degree program | 2002 |
| 65 |  | Accelerated dual-degree BS/MS program - experience with the first three years | Christensen, Douglas A.; Horch, Kenneth W. | We have initiated a pilot program that accelerates the studies of a small group of highly qualified students early in their college careers and allows them to earn both a bachelor's degree and a master's degree in about four years after starting college. It does this by introducing them early to res... | Accelerated dual-degree program | 2004 |
| 66 |  | Simulation of a phosphene field based visual prosthesis | Horch, Kenneth W.; Normann, Richard A. | A visual prosthesis for the blind based upon electrical stimulation of the visual cortex requires the development of an array of electrodes. To establish design specifications for such an electrode array, we have conducted psychophysical experiments with normally sighted subjects wearing a portable... | Visual prosthesis; Phosphene simulator | 1990 |
| 67 |  | Neural signal for skin indentation depth. I. Changing indentations | Horch, Kenneth W.; Tuckett, Robert P.; Burgess, Paul Richard | Psychophysical tests on human subjects showed that judgments of skin indentation depth made when the fingertip was indented at rates from 0.2 to 16 mm/set were quite insensitive to changes in indentation velocity. Similar results were obtained on the forearm at indentation velocities of 0.4 to 16... | Skin; Indentation; Nerve impulses | 1983 |
| 68 |  | Neural signal for skin indentation depth. II. Steady indentations | Horch, Kenneth W.; Tuckett, Robert P.; Burgess, Paul Richard | The glabrous skin of the monkey's hand was stimulated with a waveform that indented the skin at a rate of 0.4 mm/set, held the skin steadily or nearly steadily indented for 12 set or longer, and then retracted back to the starting position. Recordings were made of activity in single afferent fibe... | Skin; Indentation; Nerve impulses | 1983 |
| 69 |  | Neural signal for the intensity of a tactile stimulus | Horch, Kenneth W.; Tuckett, Robert P.; Burgess, Paul Richard | The effect of indenting the skin at different rates on the perceived intensity of the stimulus was studied by indenting the skin of the fingertip with two triangular waveforms, given as a pair. The subjects were asked to judge which member of the pair was more intense. Perceived intensity was foun... | Skin; Indentation; Nerve impulses | 1984 |
| 70 |  | Noble metal penetrating cortical stimulating electrode array: preliminary results | Horch, Kenneth W.; Normann, Richard A. | Electrical stimulation of the visual cortex causes subjects to see spots of light (phosphenes) in their visual fields. We have developed arrays of penetrating electrodes which may from the basis of a visual prosthesis centered around electrical stimulation of the visual cortex. These arrays have bee... | Visual prosthesis | 1988 |
| 71 |  | Optical immunoassay systems based upon evanescent wave interactions | Christensen, Douglas A.; Herron, James N. | Immunoassays based upon evanescent wave interactions are finding increased biosensing application. In these devices, the evanescent tail associated with total internal reflection of an incident beam at the substrate/solution interface provides sensitivity for surface-bound proteins over bulk molec... | Diagnostics; Evanescence; Planar waveguides; Human chorionic gonadotropin (hCG) | 1996 |
| 72 |  | Identification of single units in multi-unit recordings from peripheral nerves | Horch, Kenneth W. | We are developing a computer-based method for identifying individual action potentials in multi-unit peripheral nerve recordings. Threshold level, sinusoidal stimuli are used to elicit phase-locked activity from single units. These action potentials are digitized, and a template is constructed usin... | Peripheral nerve; Neural recordings; Cutaneous mechanoreceptors | 1988 |
| 73 |  | Ontogeny of diving and feeding behavior in juvenile seaturtles: Leatherback Seaturtles (Dermochelys coriacea L) and Green Seaturtles (Chelonia mydas L) in the Florida Current | Horch, Kenneth W. | We compared activity, diving behavior and response to prey by Dermochelys coriacea and Chelonia mydas during their first 8-10 weeks of development.We reared juveniles in the laboratory and, at two-week intervals, released them in the ocean for a brief trial. Each turtle towed a device used to measur... | Hatchlings; Posthatchling; Habitats | 2004 |
| 74 |  | Synaptic inputs to physiologically defined turtle retinal ganglion cells | Normann, Richard A.; Muller, Jay F.; Kolb, Helga | Two physiologically distinct, HRP-marked turtle retinal ganglion cells were examined for their morphology, GABAergic, glycinergic, and bipolar cell synaptic inputs, using electron-microscopic autoradiography and postembedding immunocytochemistry. One cell was a color-opponent, transient ON/OFF gangl... | Turtles; Neural Pathways; Synapes; Retinal Ganglion Cells | 1991 |
| 75 |  | Study of printed spiral coils for neuroprosthetic transcranial telemetry applications | Normann, Richard A.; Shah, Maulik R. | We have explored the use of printed spiral coils (PSC's) for neuroprosthetic transcranial telemetry applications. We fabricated two-dimensional PSC's on a thin (25 microns) polyimide substrate using copper (35 microns) as a conducting material. All the coils had a fixed inner diameter of 1.0 cm. We ... | Blindness; Neuroprosthesis; Transcranial Telemetry System; Prosthesis Design | 1998 |
