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CreatorTitleDescriptionSubjectDate
26 Crockett, David K.Utility of gene-specific algorithms for predicting pathogenicity of uncertain gene variantsThe rapid advance of gene sequencing technologies has produced an unprecedented rate of discovery for genome variation in humans. A growing numbered of authoritative clinical repositories archive gene variants and disease phenotype, yet there are currently many more gene variants that lack clear ann...2012
27 Kleinschmidt, Julia J.; Grosshans, Onie; Caserta, Michael; Saffel-Shrier, Susan; Tuohig, GailIntervening in midlife for optimal retirement: a guide for health educatorsFactors contributing to successful retirement deserve increased attention given the rapid growth of the aging population. Antecedent to successful retirement is successful aging. The middle aged population is an opportune target for health promotion and health education interventions as this group...Retirement; Aging Process;Education Interventions; Health Promotion1991-10
28 Baehr, WolfgangRetinoid absorption and storage is impaired in mice lacking lecithin:retinol acyltransferase (LRAT)Lecithin:retinol acyltransferase (LRAT) is believed to be the predominant if not the sole enzyme in the body responsible for the physiologic esterification of retinol. We have studied Lrat-deficient (Lrat-/-) mice to gain a better understanding of how these mice take up and store dietary retinoids a...Chromatography, High Pressure Liquid; Mice, Transgenic; Tissue Distribution2005
29 Baehr, WolfgangNovel mutation (I143NT) in guanylate cyclase-activating protein 1 (GCAP1) associated with autosomal dominant cone degenerationPURPOSE: To identify pathogenic mutations in the guanylate cyclase-activating protein 1 (GCAP1) and GCAP2 genes and to characterize the biochemical effect of mutation on guanylate cyclase (GC) stimulation. METHODS: The GCAP1 and GCAP2 genes were screened by direct sequencing for mutations in 216 pat...DNA Mutational Analysis; Mutation, Missense; Electroretinography2004
30 Baehr, WolfgangIsolation and characterization of cGMP phosphodiesterase from bovine rod outer segmentsA simple purification method has been developed for isolation of bovine cGMP phosphodiesterase from photoreceptor rod outer segments. The enzyme is peripherally membrane bound in its native state and is present in relatively high concentrations. In the bovine photoreceptors its molar ratio to rhodop...Enzyme Activation; Macromolecular Substances; Trypsin/pharmacology1979
31 Normann, Richard A.Functional reorganization of primary visual cortex induced by electrical stimulation in the cat.Compared to the high degree of plasticity observed in a juvenile, mature sensory cortices have long been held to be immutable but, recently, researchers have suggested some plasticity persists in the mature cortex. Cortical reorganization has particular saliency to the development of a cortically ba...Cat; Electrophysiology; Phosphene; Plasticity; Receptive Field; Striate Cortex2005
32 Baehr, WolfgangPharmacological and rAAV gene therapy rescue of visual functions in a blind mouse model of Leber congenital amaurosisBACKGROUND: Leber congenital amaurosis (LCA), a heterogeneous early-onset retinal dystrophy, accounts for approximately 15% of inherited congenital blindness. One cause of LCA is loss of the enzyme lecithin:retinol acyl transferase (LRAT), which is required for regeneration of the visual photopigmen...Disease Models, Animal; Genetic Vectors; Molecular Sequence Data2005
33 Kriesel, John D.; Spruance, Spotswood L.Rocky Mountain spotted fever following cardiac transplantation.ROCKY MOUNTAIN SPOTTED FEVER was first recognized in the early 1 900s in the Snake River Valley of Idaho and the Bitterroot Valley of western Montana.t In 1909, Howard Taylor Ricketts established the ixodid tick as the vector for the disease.2 Following the tick bite, the incubation period aver...Male; Adult; Humans1993
34 Durney, Carl H.An experiment in using interactive computer graphics in teaching transient transmission-line theoryAn interactive computer graphics routine was developed and used in teaching EE 553, Electromagnetic Fields, autumn quarter, 1969, in the Electrical Engineering Department of the University of Utah. The routine displayed the propagation of the voltage ave form produced by a step-function generator do...1970
35 Digre, Kathleen B.Serum vitamin A concentration is elevated in idiopathic intracranial hypertension.OBJECTIVE: The primary purpose was to investigate whether serum vitamin A concentration is associated with idiopathic intracranial hypertension (IIH). The secondary aim was to obtain pilot data regarding the amount of vitamin A ingested by patients and controls. BACKGROUND: Vitamin A is an attractiv...Vitamin A; Retinol; Idiopathic intracranial hypertension; Chromatography2007-02-01
36 Digre, Kathleen B.Selective MR imaging approach for evaluation of patients with Horner's syndrome.PURPOSE: To assess the usefulness of MR in the evaluation of patients with Horner's syndrome. PATIENTS AND METHODS: We prospectively performed MR imaging in 33 patients with Horner's syndrome (13 preganglionic and 20 postganglionic) using a protocol specifically designed for pre- and postganglionic ...Horner Syndrome; Magnetic Resonance Imaging; Epidemiology1992-01
37 Zhang, KangNovel mutation in the ELOVL4 gene causes autosomal dominant Stargardt-like macular dystrophyPURPOSE. To conduct clinical and genetic studies in a European family with autosomal dominant Stargardt-like macular dystrophy (adSTGD-like MD) and to investigate the functional consequences of a novel ELOVL4 mutationMacular dystrophy; ELOVL4 mutation; Genetics2004
38 Fuhrmann, Sabine; Zhang, Jianmin; Vetter, Monica L.Investigation of Frizzled-5 during embryonic neural development in mouseCellular and tissue--tissue interactions regulate development of the central nervous system (CNS) and a paramount question is what is the nature of the signals involved in these interactions. The vertebrate eye represents an excellent and challenging CNS model because it contains multiple cell and ...Mouse; Eye; Optic cup; Morphogenesis; Retina; Lens; Wnt; Frizzled; Pituitary2008
39 Kriesel, John D.; Maulden, Sarah Annamarie; Spruance, Spotswood L.Anti-interleukin-6 antibodies inhibit herpes simplex virus reactivation.Herpes simplex viruses (HSVs) infect epithelial cells, become localized in neurons, and can reactivate in response to a variety of stimuli, including ultraviolet light and hyperthermia. The sequence of gene activation during viral replication is known, but the molecular linkage between exogenous sti...Mice, Inbred BALB C; Tumor Necrosis Factor-alpha; Virus Activation1997
40 Frederick, Jeanne M.; Thulin, Craig; Bernstein, Paul S.Identification and characterization of a Pi isoform of glutathione S-transferase (GSTP1) as a zeaxanthin-binding protein in the macula of the human eyeUptake, metabolism, and stabilization of xanthophyll carotenoids in the retina are thought to be mediated by specific xanthophyll-binding proteins (XBPs). A membrane-associated XBP was purified from human macula using ion-exchange chromatography followed by gel-exclusion chromatography. Two-dimensio...Circular Dichroism; Isoelectric Focusing; Macula Lutea; Xanthophylls2004
41 Baehr, WolfgangPhenolic components from the leaves of the Ginkgo tree (Ginkgo biloba L)No summary- Article is in German.Flavonoids; Chromatography; Phenols; Plant Extracts; Ginkgo Biloba L.1968-05
42 Baehr, WolfgangNoninvasive two-photon imaging reveals retinyl ester storage structures in the eyeVisual sensation in vertebrates is triggered when light strikes retinal photoreceptor cells causing photoisomerization of the rhodopsin chromophore 11-cis-retinal to all-trans-retinal. The regeneration of preillumination conditions of the photoreceptor cells requires formation of 11-cis-retinal in t...Microscopy, Fluorescence; Visual Perception; Membrane Proteins2004
43 Baehr, WolfgangEvaluation of the 17 kda prenyl binding protein as a regulatory protein for phototransduction in retinal photoreceptorsThe mammalian rod photoreceptor phosphodiesterase (PDE6) holoenzyme is isolated in both a membrane-associated and a soluble form. Membrane binding is a consequence of prenylation of PDE6 catalytic subunits, whereas soluble PDE6 is purified with a 17-kDa prenyl-binding protein (PDEdelta) tightly boun...Amino Acid Sequence; Immunohistochemistry; Phosphoric Diester Hydrolases2005
44 Baehr, WolfgangReceptors for advanced glycation end products as progressive factors in age-related macular degenerationAdvanced glycation end products (AGE) exacerbate disease progression through two general mechanisms: modifying molecules and forming nondegradable aggregates, thus impairing normal cellular/tissue functions, and altering cellular function directly through receptor-mediated activation. In the prese...Advanced glycation end products; AGE; receptor for AGE-mediated cellular activation; RAGE2004
45 Bernstein, Paul S.; Gellermann, WernerRaman detection of macular carotenoid pigments in intact human retinaPURPOSE: To develop and test a novel noninvasive optical technique suitable for the objective measurement of macular carotenoid levels in human retina. METHODS: A resonance Raman scattering apparatus was constructed to measure carotenoid levels in flat-mounted human retinas and eyecups and in experi...Rana pipiens; Spectrum Analysis, Raman; Xanthophylls1998
46 Zhang, KangSpectrum and frequency of FZD4 mutations in familial exudative vitreoretinopathyMutations in the frizzled-4 gene (FZD4) have recently been associated with autosomal dominant familial exudative vitreoretinopathy (FEVR) in families linking to the EVR1 locus on the long arm of chromosome 11. The purpose of this study was to screen FZD4 in a panel of 40 patients with FEVR to ident...Frizzled-4 gene; FZD4; Mutation; autosomal dominant familial exudative autosomal dominant familial exudative; FEVR2004
47 Normann, Richard A.; Shoham, ShyEncoding mechanisms for sensory neurons studied with a multielectrode array in the cat dorsal root ganglionRecent advances in microelectrode array technology now permit a direct examination of the way populations of sensory neurons encode information about a limb's position in space. To address this issue, we recorded nerve impulses from about 100 single units simultaneously in the L6 and L7 dorsal root ...Sensory; Encoding; Multielectrode; Dorsal Root Ganglion; Cutaneour; Muscle2004
48 Baehr, WolfgangCharacterization of bovine rod outer segment G-proteinA simple modified procedure is described for isolating and purifying peripherally bound membrane proteins from bovine rod outer segment disks. The methods yield milligram quantities of G-protein and cGMP phosphodiesterase which are suitable for reconstitution with membranes containing visual pi...Heterotrimeric GTP-Binding Proteins; Macromolecular Substances; Rhodopsin1982
49 Baehr, WolfgangAnnotation and analysis of 10,000 expressed sequence tags from 3 mouse eye cDNA librariesBACKGROUND: As a biomarker of cellular activities, the transcriptome of a specific tissue or cell type during development and disease is of great biomedical interest. We have generated and analyzed 10,000 expressed sequence tags (ESTs) from three mouse eye tissue cDNA libraries: embryonic day 15.5 (...Cluster Analysis; DNA, Complementary; Gene Expression Profiling2003
50 Jones, Bryan W.Molecular phenotyping of retinal ganglion cellsClassifying all of the ganglion cells in the mammalian retina has long been a goal of anatomists, physiologists, and cell biologists. The rabbit retinal ganglion cell layer was phenotyped using intrinsic small molecule signals (aspartate, glutamate, glycine, glutamine, GABA, and taurine) and glutama...Aspartic Acid/metabolism; Image Cytometry/methods2002
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