Honors Theses Open Access
 
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CreatorTitleDescriptionSubjectDate
26 Shapiro, DarienActivation of transient receptor potential ankyrin-1 by wood smoke particulate materialExposure to wood smoke particulate matter (WSPM) has been linked to exacerbation of pre-existing respiratory conditions such as asthma, development of chronic obstructive pulmonary disease (COPD), and premature deaths. While it is clear that WSPM exposure is hazardous to human health, the molecular ...Smoke - Physiological effect2012-05
27 Trakhimets, AlesiaPre-clinical trials of anti-neoplastic drugs using zebrafish with T-cell cancerNote: To agree with NCBI nomenclature guidelines, human gene abbreviations are italicized and capitalized; human protein abbreviations are non-italicized and capitalized, and zebrafish gene abbreviations are italicized in lowercase. T lymphocytes, or T-cells, are blood cells that normally fight vira...Antineoplastic agents - Testing; Zebra danio2013-04
28 Scott, IsabelleTropical analog to the log canonical thresholdIn algebraic geometry, the log canonical threshold is a property of singularities of planar curves. While singularities have multiplicities, the log canonical threshold can be a more telling invariant. It helps to classify curves beyond what the multiplicity indicates by examining how quickly the in...Geometry, Algebraic2013-04
29 Rose, StevenBiofuel cells for self powered arsenic detectionResearch in the Minteer group has centered on procedures for immobilizing enzymes and organelles on carbon electrodes for use in sensory and fuel cell applications. Similar strategies have been used to prepare a series of electrodes capable of pyruvate oxidation which, in the presence of arsenic, wi...Fuel cells; Arsenic - Detection2013-05
30 Burga, Carlos AlbertoBinary superlattices of semiconductor nanocrystals : a path towards possible high-temperature superconductivityThis thesis provides a platform to experimentally test Dr. Daniel Mattis' theoretical work on the possible superconductive behavior of nanostructured intrinsic semiconductors1-2. The theoretical work hinged on the nano-scale architecture of semiconductors. Therefore, using various types of semicondu...Semiconductor nanocrystals; Superconductivity; Superlattices as materials2013-05
31 Edwards, Jennifer LynnApplication of a TBHP-mediated Wacker-type oxidation to internal alkenesThe Wacker oxidation allows access to methyl ketones from terminal alkenes. This transformation is important for industrial, synthetic, and medicinal chemists, as carbonyls are present in many natural and pharmaceutical products. With the carbonyl, a wide variety of reactions become available, such ...Wacker-type oxidatioin - Research; TBHP2013-05
32 Chure, Griffin DanielFLHE influences cellular morphology through control of flagellar assembly in escherichia coliThe bacterial flagellar motor is a complex nanomachine composed of thousands of individual protein subunits. One of these proteins, FlhE, has not been studied in depth and its function is not completely understood. The flhE gene is cotranscribed with flhB and flhA in the flhBAE flagellar operon. In ...Escherichia coli; Flagella (Microbiology)2013-05
33 Little, Nancy AnnCharacterizing and mapping l(3)7E103 a gene required for Drosophila dorsal closureDorsal closure in the fruit fly Drosophila melanogaster is a complex morphogenetic process dependent upon three embryonic tissues: the lateral epidermis, leading edge epidermis, and amnioserosa. Additionally, the Jun N-terminal Kinase (JNK) and Decapentaplegic (Dpp) signaling cascades are required f...Drosophila melanogaster - Genetics; Drosophila melanogaster - Embryology2013-05
34 Thomas, NikitaCellular ultrastructure of C. elegans nervous systemDetermining the ultrastructural organization of the nervous system is a key step in understanding how complex behavior is generated. For a nervous system to function, it must be wired accurately. A complete wiring diagram, referred to as a connectome, can be created by tracing neuronal profiles thro...Caenorhabditis elegans - Nervous system2013-05
35 Richards, JacksonChasing channels: Progress in calcium channel localization in the C. Elegans synapseCalcium channels play a crucial role in neurotransmission by facilitating the flow of calcium ions necessary for synaptic vesicle fusion and neurotransmitter release. Different types of calcium channels participate in this process in the neurons of the nematode C. elegans. L- and N-type channels res...Calcium channels; Synaptic vesicles; Caenorhabditis elegans2013-05
36 Gondolo, AlessandroCharacterization and Synthesis of Rayleigh Damped Elastodynamic NetworksWe consider damped elastodynamic networks where the damping matrix is assumed to be a non-negative linear combination of the stiffness and mass matrices (Rayleigh damping). We give here a characterization of the frequency response of such networks. We also answer the synthesis question for such netw...Damping (Mechanics) - Mathematics2013-05
37 Lee, ZacharyUsing Drosophila to investigate p53 life-or-death decisionsThe p53 tumor suppressor is a central regulator of cellular responses to DNA damage. When DNA damage cannot be repaired most cells undergo p53-dependent cell death. Thisp55-mediated apoptosis is important to eliminate cells with damaged genomes and provides an important block to the development of c...Biology2013-05
38 Nicolo, TeraCharacterization of mitochondria-modified electrodesIn order to develop an herbicide sensor, yeast, potato, and bovine heart mitochondria were isolated and immobilized onto Toray paper electrodes. Cyclic voltammetry showed two redox peaks at 186 ± 14 mV vs. SCE and -357 ± 24 mV vs. SCE with an E1/2 of -128 mV. Scan rate studies suggested the proces...Electrodes; Herbicides - Detection2013-05
39 Sullivan, Steven M.A trace formula for G2An n-dimensional matrix representation of a group G on a vector space V is a homomorphism from G to GL(V). For our purposes, we consider an irreducible representation to be a representation which cannot be decomposed into the direct sum of smaller-dimensional representations. Let H be a subgroup of ...Trace formulas2013-05
40 Simonsen, KyleBreast cancer knowledge and attitudes among women in ArmeniaBackground: Breast cancer, the most common invasive cancer among women, has high incidence and mortality rates among women in the Republic of Armenia. Advanced stage at detection limits treatment options and contributes to high morbidity and mortality. Understanding women's breast cancer knowledge a...Breast - Cancer; Breast - Cancer - Patients - Attitudes; Breast - Cancer - Patients - Armenia (Republic)2013-07
41 Pecchia-Bekkum, AnnikaApplications of controlled DNA assembly and disassembly in biosensing and responsive drug deliveryDeoxyribonucleic acid (DNA) provides many exciting functions outside of simply encoding genetic information. Herein, we report two techniques to control the assembly and disassembly of nucleic acids. Within these techniques, DNA is used as a programmable material for biosensing and drug delivery. In...Nucleic acids - Biotechnology2013-08
42 Borrowman, WilliamGas exchange of co-occurring plant species of the Great Basin Desert in an irrigated common gardenThe majority of plants in the Great Basin ecosystem have adapted to cope with drought during summer. While general characteristics of these plants have been studied in non-managed environments it is important to investigate the physiology of these plants when additional water is supplied. In this ...Urban heat island -- Prevention; Desert plants -- Ecology -- Great Basin -- Research; Plant ecophysiology -- Research; Irrigation -- Environmental aspects; Red Butte Garden (Salt Lake City, Utah)2014-04
43 Estrada, JohannaBCR-ABL1 compound mutations combining key kinase domain positions confer clinical resistance to ponatinib in Philadelphia cromosome-positive leukemiaCML 1s caused by a random reciprocal translocation that joins the ABL1 gene on chromosome 9, with the BCR gene on chromosome 22. The result is the formation of the oncogenic BCR-ABL1 gene. This derivative chromosome is widely known as the Philadelphia Chromosome (Ph+), and it encodes a deregulated, ...Leukemia -- Genetic aspects -- Research Leukemia -- Treatment -- Research2014-04
44 Weaver, BradleyHypoxia and the mesenchymal transition in gliomaRecent advances in targeted therapy for cancer have had little influence on survival for patients diagnosed with Glioblastoma (GBM, WHO Grade IV tumors), and median survival time remains stagnant at 12-15 months post diagnosis. Genomic profiling of GBM indicates clear phenotypic subsets of these tum...Glioblastoma multiforme; Gliomas; Hypoxia; Mesenchymal transition2014-04
45 Farrall, NicholasStructural characterization of the full-length exocyst complex by transmission electron cryo-microscopyThe exocyst is a conserved octameric protein complex in eukaryotes that is essential for tethering and fusion of vesicles to the plasma membrane. Composed of eight subunits, it is essential for growth, secretion, and developmental processes and has been implicated in cell motility, autophagy, cell d...Saccaromyces cerevisaie - Cytology; Cryomiscroscopy - Research2014-05
46 Watkins, Ryan DavisSuppression of lymphangiogenesis using VEGF-C trapThe lymphatic system is responsible for controlling systemic fluid buildup. Lymphangiogenesis is a dynamic process involving sprouting, and maintaining new lymphatic vasculature. Vascular endothelial growth factor C (VEGF-C) is as a key growth factor that induces lymphangiogenesis by binding VEGF re...Lymphatics - Growth; Vascular endothelial growth factors - Antagonists; Lymphangiogenesis; VEGF-C trap2014-05
47 Wallace, Joshua J.Lyman-alpha emission as a probe of galaxy environmentsAs a result of resonant scatterings off hydrogen atoms, Lya emission from star-forming galaxies provides a potential probe of the neutral gas environment around them. In order to determine the utility of Lya emission as a probe of gas environments we study the effects of environmental anisotropy on ...Galaxies - Spectra2014-05
48 Fullmer, Alexander T.Optimization of gamma/hadron separation under variable source intensities and energy spectraThe High Altitude Water Cherenkov (HAWC) gamma-ray observatory consists of an array of water Cherenkov tanks that can detect extensive air showers (EAS) generated by astrophysical cosmic rays and gamma rays. One of the greatest challenges in using the HAWC observatory to search for astrophysical gam...Gamma ra sources - Observations; Cosmic rays - Observations; Gamma ray astronomy - Research2014-05
49 Prestgard-Duke, MichaelDynamin localization in Caenorhabditis ElegansDynamin is a 100-KDa GTPase that is essential for endocytosis. The classic model of endocytosis is a sequential mechanism: first, cell membrane is bent and internalized via the formation of a clathrin coat; next, dynamin facilitates GTP hydrolysis, resulting in membrane scission as the newly formed ...Caenorhabditis elegans; Guanosine triphosphatase; Endocytosis2014-05
50 Neville, RoselynConstitutively activated AKT is not sufficient to keep cells alive following epithelial cell extrusionThe PI3 kinase (PI3K)/AKT signaling pathway regulates many fundamental behaviors of the cell. If any of the key members of this pathway are deregulated, it can lead to malignant changes in the cell. AKT enhances the survival of cells by inhibiting pro-apoptotic processes, and promoting pathways for ...PI3K/AKT - Chemistry; Cancer metastasis2014-05
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