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26 Hughes, Kelly T.The effects of codon context on in vivo translation speedWe developed a bacterial genetic system based on translation of the his operon leader peptide gene to determine the relative speed at which the ribosome reads single or multiple codons in vivo. Low frequency effects of so-called ‘‘silent'' codon changes and codon neighbor (context) effects could...2014-01-01
27 Beckerle, Mary C.Mathematical modeling of the dynamic mechanical behavior of neighboring sarcomeres in actin stress fibersActin stress fibers (SFs) in live cells consist of series of dynamic individual sarcomeric units. Within a group of consecutive SF sarcomeres, individual sarcomeres can spontaneously shorten or lengthen without changing the overall length of this group, but the underlying mechanism is unclear. We us...2014-01-01
28 Adler, Frederick R.Deconvolution of isotope signals from bundles of multiple hairsSegmental analysis of hair has been used in diverse fields ranging from forensics to ecology to measure the concentration of substances such as drugs and isotopes. Multiple hairs are typically combined into a bundle for segmental analysis to obtain a high-resolution series of measurements. Individua...2014-01-01
29 Varner, Johanna; Dearing, Denise M.The importance of biologically relevant microclimates in species distribution models and habitat suitability assessmentsPredicting habitat suitability under climate change is vital to conserving biodiversity. However, current species distribution models rely on coarse scale climate data, whereas fine scale microclimate data may be necessary to assess habitat suitability and generate predictive models. Here, we evalua...2013
30 Clayton, Dale H.Darwins finches combat introduced nest parasites with fumigated cottonIntroduced parasites are a threat to biodiversity when naïve hosts lack effective defenses against such parasites [1]. Several parasites have recently colonized the Galápagos Islands, threatening native bird populations [2]. For example, the introduced parasitic nest fly Philornis downsi (Diptera:...2014-01-01
31 Coley, Phyllis D.On tropical forests and their pestsBiologists have long been intrigued by the diversity of tropical forests, where 1 hectare may hold more than 650 tree species-more than in all of Canada and the continental United States. Eco- logical theory suggests that if species are too similar in their resource use, one will out- compete the ot...2014-01-01
32 Adler, Frederick R.Reply:We appreciate the comments of Drs. Craig and Simpson and Drs. Mullins and Schwartz, and the challenge they raise to make MALD more believable, comprehensible, and usable. Acetaminophen (APAP) toxicity is indeed a complex process involving multiple steps. Although the underlying mathematics is more i...2012-01-01
33 Parkinson, John StansfieldAn unorthodox sensory adaptation site in the E. coli serine chemoreceptorThe serine chemoreceptor of E. coli contains four canonical methylation sites for sensory adaptation that lie near inter-subunit helix interfaces of the Tsr homodimer. An unexplored fifth methylation site, E502, lies at an intra-subunit helix interface, closest to the HAMP domain that controls input...2014-01-01
34 Bowling, David R.Interannual variation in seasonal drivers of soil respiration in a semi-arid Rocky Mountain meadowSemi-arid ecosystems with annual moisture inputs dominated by snowmelt cover much of the western United States, and a better understanding of their seasonal drivers of soil respiration is needed to predict consequences of climatic change on soil CO2 efflux. We assessed the relative importance of tem...2012-01-01
35 Adler, Frederick R.Mathematical modeling of liver injury and dysfunction after acetaminophen overdose: early discrimination between survival and deathAcetaminophen is the leading cause of acute liver injury in the developed world. Timely administration of N-Acetylcysteine (N-Ac) prevents the progression of serious liver injury and disease, while failure to administer N-Ac within a critical time frame allows disease progression and in the most sev...2012-01-01
36 Clayton, Dale H.An experimental test of the effects of behavioral and immunological defenses against vectors: do they interact to protect birds from blood parasites?Background: Blood-feeding arthropods can harm their hosts in many ways, such as through direct tissue damage and anemia, but also by distracting hosts from foraging or watching for predators. Blood-borne pathogens transmitted by arthropods can further harm the host. Thus, effective behavioral and im...2014-01-01
37 Coley, Phyllis D.Chemical and bioactive natural products from microthyriaceae sp., an endophytic fungus from a tropical grassIn screening for natural products with antiparasitic activity, an endophytic fungus, strain F2611, isolated from above-ground tissue of the tropical grass Paspalum conjugatum (Poaceae) in Panama, was chosen for bioactive principle elucidation. Cultivation on malt extract agar (MEA) followed by bioas...2014-01-01
38 Goller, FranzMotor control of sound frequency in birdsong involves the interaction between air sac pressure and labial tensionFrequency modulation is a salient acoustic feature of birdsong. Its control is usually attributed to the activity of syringeal muscles, which affect the tension of the labia responsible for sound production. We use experimental and theoretical tools to test the hypothesis that for birds producing to...2014-01-01
39 Parkinson, John StansfieldMutational analysis of the P1 phosphorylation domain in E. coli CheA, the signaling kinase for chemotaxisThe histidine autokinase CheA functions as the central processing unit in the Escherichia coli chemotaxis signaling machinery. CheA receives autophosphorylation control inputs from chemoreceptors and in turn regulates the flux of signaling phosphates to the CheY and CheB response regulator proteins...2014-01-01
40 Hughes, Kelly T.The effect of cell growth phase on the regulatory cross-talk between flagellar and Spi1 virulence gene expressionThe flagellar regulon controls Salmonella biofilm formation, virulence gene expression and the production of the major surface antigen present on the cell surface: flagellin. At the top of a flagellar regulatory hierarchy is the master operon, flhDC, which encodes the FlhD4C2 transcriptional complex...2014-01-01
41 Parkinson, John StansfieldHAMP domain structural determinants for signalling and sensory adaptation in Tsr, the E. coli serine chemoreceptorMotile Escherichia coli cells track chemical gradients with high sensitivity over wide concentration ranges [recently reviewed in (Hazelbauer et al., 2008; Hazelbauer & Lai, 2010)]. Stimulus detection, amplification, and integration occur in an arrayed network of signaling complexes that contain tra...2014-01-01
42 Capecchi, Mario R.Sepp1UF forms are N-terminal selenoprotein P truncations that have peroxidase activity when coupled with thioredoxin reductase-1Mouse selenoprotein P (Sepp1) consists of an N-terminal domain (residues 1-239) that contains 1 selenocysteine (U) as residue 40 in a proposed redox-active motif (-UYLC-) and a Cterminal domain (residues 240-361) that contains 9 selenocysteines. Sepp1 transports selenium from the liver to other tiss...2014-01-01
43 Bohs, Lynn A.Two new species from the brevantherum clade of solanum (solanaceae) from eastern BrazilTwo new species of Solanum (Solanaceae) from eastern Brazil are described. Solanum anisocladum Giacomin & Stehmann is similar to S. megalochiton Mart., but differs by the indument of the adaxial leaf surface, which is composed of long porrect-stellate and unbranched trichomes. It also has a more rob...2013-01-01
44 Adler, Frederick R.Long-term models of oxidative stress and mitochondrial damage in insulin resistance progressionInsulin resistance, characterized by a reduced cellular response to insulin, is a major factor in type 2 diabetes pathogenesis, with a complex etiology consisting of a combination of environmental and genetic factors. Oxidative stress, which develops through an accumulation of toxic reactive oxygen ...2014-01-01
45 Crespo, Jose GuillermoDislodgement effect of natural semiochemicals released by disturbed triatomines: a possible alternative monitoring toolThe quick detection of domestic and peridomestic triatomines in their environments becomes difficult without the use of dislodgement substances that flush them out from their shelters. At present, tetramethrin 0.2% is being widely used in control programs. Although it is an efficient dislodging agen...2013-01-01
46 Jorgensen, ErikAxon regeneration genes identified by RNAi screening in C. elegansAxons of the mammalian CNS lose the ability to regenerate soon after development due to both an inhibitory CNS environment and the loss of cell-intrinsic factors necessary for regeneration. The complex molecular events required for robust regeneration of mature neurons are not fully understood, part...2014-01-01
47 Varner, Johanna M.; Dearing, Maria-DeniseResearch data to accompany Varner and Dearing 2014 "Relevant Microclimates and Habitat Suitability"Data package to accompany "Relevant Microclimates and Habitat Suitability". Package contains a ReadMe file and the following Excel spreadsheets: Elevation Comparison, Moss Transplant Data, Tempdata by site, Variogram-Ambient, Variogram_Ambient Shortrange, Variogram-Surf, Variogram-Talus.Research data; Relevant microclimates; Habitat suitability2014
48 Bowling, David R.Assessing filtering of mountaintop CO2 mole fractions for application to inverse models of biosphere-atmosphere carbon exchangeThere is a widely recognized need to improve our understanding of biosphere-atmosphere carbon exchanges in areas of complex terrain including the United States Mountain West. CO2 fluxes over mountainous terrain are often difficult to measure due to unusual and complicated influences associated with ...2012-01-01
49 Sekercioglu, CaganCorrelates of elevational specialisation in Southeast Asian tropical birdsThe understanding of elevational selectivity in extremely rich tropical biotas is critical to the study of accelerating human-mediated environmental changes (e.g., deforestation and global climate warming). This paper explores the characteristics of Southeast Asian birds that are altitudinal special...2012-01-01
50 Crespo, Jose GuillermoRecruitment of motor units in flight muscles accounts for pheromone-mediated modulation of pre-flight heating rates of males mothsInsecta; Physiology; Pheromone; Thermobiology; Muscle; Flight; Behavior; Helicoverpa zea2013
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