|
|
Creator | Title | Description | Subject | Date |
| 26 |
 |
Christensen, Douglas A. | Extending the two-dimensional FDTD method to hybrid electromagnetic systems with active and passive lumped elements | This paper extends the finite-difference time-domain (FDTD) method to include distributed electromagnetic systems with lumped elements (a hybrid system) and voltage and current sources. FDTD equations that include nonlinear elements like diodes and transistors are derived. Calculation of driving-p... | Finite-difference time-domain method; Lumped elements | 1992-04 |
| 27 |
 |
Christensen, Douglas A. | Acoustic droplet vaporization, cavitation, and therapeutic properties of copolymer-stabilized perfluorocarbon nanoemulsions | Acoustic and therapeutic properties of Doxorubicin (DOX) and paclitaxel (PTX)-loaded perfluorocarbon nanoemulsions have been investigated in a mouse model of ovarian cancer. The nanoemulsions were stabilized by two biodegradable amphiphilic block copolymers that differed in the structure of the hydr... | Cancer therapy; Targeted drug delivery; Nanobubbles; Ultrasound; Perfluoropentane | 2009 |
| 28 |
 |
Christensen, Douglas A. | Ultrasound beam propagation using the hybrid angular spectrum method | We introduce a fast and accurate numerical method for simulating the propagation of an ultrasound beam inside inhomogeneous tissue for mapping beam absorption, refraction and diffraction in the body. The technique, called the hybrid angular spectrum method, is an extension of the angular spectrum m... | Ultrasound beam propagation; Medical ultrasound; Inhomogeneous tissue; Beam simulation | 2008-08 |
| 29 |
 |
Normann, Richard A. | Control of retinal sensitivity. I. Light and dark adaptation of vertebrate rods and cones | Rods and cones in Necturus respond with graded hyperpolarization to test flashes spanning about 3.5 log units of intensity. Steady background levels hyperpolarize the rods, and the rod responses become progressively smaller as background level is increased. In cones, higher background levels reduce... | Retina;Light and Dark Adaptation; Recepters; Bipolars; Ganglion Cells | 1974 |
| 30 |
 |
Gesteland, Raymond F.; Weiss, Robert B. | Efficient shine- Dalgarno sequence but not translation is necessary for LacZ mRNA stability in Escherichia coli | The 5' ends of many bacterial transcripts are important in determining mRNA stability. A series of Shine-Dalgarno (SD) sequence changes showed that the complementarity of the SD sequence to the anti-SD sequence of 16S rRNA correlates with lacZ mRNA stability in Escherichia coli. Several initiation c... | Protein Biosynthesis; Ribosomes; Escherichia coli; Shine-Dalgarno Sequence | 1994 |
| 31 |
 |
Horch, Kenneth W. | Muscle recruitment with intrafascicular electrodes | We have studied muscle recruitment with Tefloninsulated, 25 pm diameter, Pt-Ir intrafasicular electrodes implanted in nerves innervating the gastrocnemius and soleus muscles of cats. The purpose of this study was to measure the performance of these bipolar electrodes, which had been designed to... | Functional neuromuscular stimulation (FNS); Intrafascicular electrode | 1991 |
| 32 |
 |
Christensen, Douglas A. | Introduction to biomedical engineering: biomechanics and bioelectricity - part II | Intended as an introduction to the field of biomedical engineering, this book covers the topics of biomechanics (Part I) and bioelectricity (Part II). Each chapter emphasizes a fundamental principle or law, such as Darcy's Law, Poiseuille's Law, Hooke's Law, Starling's Law, levers and work in the... | Bioelectricity; Kirchhoff's voltage law; Kirchhoff's current law; Coulomb's law; Thevenin equivalent circuits; Nernst potential; Matlab | 2009 |
| 33 |
 |
Horch, Kenneth W. | Identification of single units in multi-unit recordings from peripheral nerves | We are developing a computer-based method for identifying individual action potentials in multi-unit peripheral nerve recordings. Threshold level, sinusoidal stimuli are used to elicit phase-locked activity from single units. These action potentials are digitized, and a template is constructed usin... | Peripheral nerve; Neural recordings; Cutaneous mechanoreceptors | 1988 |
| 34 |
 |
Christensen, Douglas A. | Resonant inductive applicator for neck hyperthermia | We have designed and phantom tested an inductive applicator especially suited for producing hyperthermia in cancerous regions in the neck. The applicator is tuned to resonate near 27 MHz; its inductive nature has the advantage of efficient coupling to the irregular neck anatomy. An inhomogeneou... | Hyperthermia applicator; Phantom tests | 1989 |
| 35 |
 |
Hansen, Mark S.; Healy, Lindsey J.; Johnson, Christopher R.; Capecchi, Mario R.; Keller, Charles; Jones, Greg M. | Virtual histology of transgenic mouse embryos for high-throughput phenotyping. | A bold new effort to disrupt every gene in the mouse genome necessitates systematic, interdisciplinary approaches to analyzing patterning defects in the mouse embryo. We present a novel, rapid, and inexpensive method for obtaining high-resolution virtual histology for phenotypic assessment of mouse ... | Forkhead Transcription Factors; Paired Box Transcription Factors | 2006 |
| 36 |
 |
Gesteland, Raymond F.; Atkins, John F.; Felden, Brice; McCutcheon, John P. | Probing the structure of the Escherichia coli 10Sa RNA (tmRNA) | The conformation of the Escherichia coli 10Sa RNA (tmRNA) in solution was investigated using chemical and enzymatic probes. Single- and double-stranded domains were identified by hydrolysis of tmRNA in imidazole buffer and by lead(II)-induced cleavages. Ribonucleases T1 and S1 were used to map unpai... | Covariation; Pseudoknot; Structural Probing; 10Sa RNA; tmRNA | 1997 |
| 37 |
 |
Normann, Richard A. | Functional reorganization of primary visual cortex induced by electrical stimulation in the cat. | Compared to the high degree of plasticity observed in a juvenile, mature sensory cortices have long been held to be immutable but, recently, researchers have suggested some plasticity persists in the mature cortex. Cortical reorganization has particular saliency to the development of a cortically ba... | Cat; Electrophysiology; Phosphene; Plasticity; Receptive Field; Striate Cortex | 2005 |
| 38 |
 |
Gesteland, Raymond F.; Atkins, John F. | Frameshifting in gene 10 of bacteriophage T7 | Gene 10 of bacteriophage T7, which encodes the most abundant capsid protein, has two products: a major product, 10A (36 kDa), and a minor product, 10B (41 kDa). 10B is produced by frameshifting into the -1 frame near the end of the 10A coding frame and is incorporated into the capsid. The frameshift... | Frameshifting; Bacteriophage T7; RNA, Viral; Gene Expression | 1991 |
| 39 |
 |
Normann, Richard A.; Shoham, Shy | Encoding mechanisms for sensory neurons studied with a multielectrode array in the cat dorsal root ganglion | Recent advances in microelectrode array technology now permit a direct examination of the way populations of sensory neurons encode information about a limb's position in space. To address this issue, we recorded nerve impulses from about 100 single units simultaneously in the L6 and L7 dorsal root ... | Sensory; Encoding; Multielectrode; Dorsal Root Ganglion; Cutaneour; Muscle | 2004 |
| 40 |
 |
Gesteland, Raymond F.; Ives, Jeffrey T.; Stockham, Thomas G. | Automated film reader for DNA sequencing based on homomorphic deconvolution | An automated reader for electrophoresis based DNA sequencing methods is described that provides fast and accurate sequence determination. Digitized sequencing lanes are processed with homomorphic blind deconvolution in preparation for peak detection, interlane alignment, peak refinement and base cal... | Sequence Analysis; Electrophoresis; Automated Film Reader; Homomorphic Deconvolution | 1994 |
| 41 |
 |
Christensen, Douglas A.; Herron, James N. | Rapid single nucleotide polymorphism detection for personalized medicine applications using planar waveguide fluorescence sensors | Personalized medicine is an emerging field in which clinical diagnostics information about a patient's genotype or phenotype is used to optimize his/her pharmacotherapy. This article evaluates whether planar waveguide fluorescent sensors are suitable for determining such information from patient tes... | Personalized medicine; Planar waveguides; Fluorescence sensors; Evanescent excitation; Fluorescence; Hybridization; Molecular diagnostics; Peptide nucleic acid; Point of care; Single base extension; Single nucleotide polymorphism | 2006 |
| 42 |
 |
Christensen, Douglas A. | Computer-aided design of two-dimensional electric-type hyperthermia applicators using the finite-difference time-domain method | A hyperthermia applicator design tool consisting of a finite-difference time-domain (FDTD) technique in combination with a graphical display of electric fields and normalized linear temperature rise is described. This technique calculates, rather than assumes, antenna current distributions; it incl... | Finite-difference time-domain method; Hyperthermia applicator | 1991-09 |
| 43 |
 |
Normann, Richard A.; Maynard, Edwin M. | Neuronal interactions improve cortical population coding of movement direction | Interactions among groups of neurons in primary motor cortex (MI) may convey information about motor behavior. We investigated the information carried by interactions in MI of macaque monkeys using a novel multielectrode array to record simultaneously from 12-16 neurons during an arm-reaching task. ... | Motor Cortex; Monkey; Population Coding; Movement | 1999 |
| 44 |
 |
Normann, Richard A. | Effects of background illumination on the photoresponses of red and green cones | 1. The photoresponses of light- and dark-adapted red and green cone photoreceptors were recorded intracellularly in the retina of the turtle, Pseduemys scripta elegans. Background illumination produced similar effects on both types of cones. 2. In response to the onset of a prolonged, steady backgro... | Turtles; Adaptation, Ocular; Retina; Signal Transmission | 1979 |
| 45 |
 |
Horch, Kenneth W. | Proposed specifications for a lumbar spinal cord electrode array for control of lower extremities in paraplegia | The goal of the study was to provide specifications for a stimulating electrode array to be implanted in the lumbosacral spinal cord as part of a functional neuromuscular stimulation (FNS) system for control of lower extremity muscles in paralyzed individuals. Dual channel stimulation of the qua... | Stimulating electrode array; FNS; Functional neuromuscular stimulation | 1997 |
| 46 |
 |
Christensen, Douglas A. | Ultrasound-enhanced localized chemotherapy of drug-sensitive and multidrug resistant tumors | A new modality of targeted tumor chemotherapy is based on the drug encapsulation in polymeric nanoparticles followed by a localized release at the tumor site triggered by focused ultrasound. Effect of 1 MHz and 3 MHz unfocused ultrasound applied locally to the tumor on the Doxorubicin (DOX) biodistr... | Ultrasound-enhanced chemotherapy; Drug-resistant tumors; Biodistribution; Tumor sonication | 2006 |
| 47 |
 |
Hendee, Shonn P.; Faour, Fouad A.; Christensen, Douglas A.; Patrick, Baharah; Durney, Carl H.; Blumenthal, Donald K. | Effects of weak extremely low frequency magnetic fields on calcium/calmodulin interactions. | Mechanisms by which weak electromagnetic fields may affect biological systems are of current interest because of their potential health effects. Lednev has proposed an ion parametric resonance hypothesis (Lednev, 1991, Bioelectromagnetics, 12:71-75), which predicts that when the ac, frequency of a c... | Electromagnetic Fields; Calcium-binding Proteins; Lednev's Theory | 1996-06 |
| 48 |
 |
Horch, Kenneth W. | Changes in primary afferent depolarization of sensory neurones during peripheral nerve regeneration in the cat | I. Micro-electrode recordings were made from normal and regenerating sural nerve fibres in cats. Increases in the excitability of the central terminals of these fibres after conditioning stimulation of other sural nerve fibres were taken as evidence for primary afferent depolarization. 2. At all... | Micro-electrode recording; Nerve regeneration; Primary afferent depolarization | 1981 |
| 49 |
 |
Horch, Kenneth W.; Tuckett, Robert P.; Burgess, Paul Richard | Neural signal for skin indentation depth. I. Changing indentations | Psychophysical tests on human subjects showed that judgments of skin indentation depth made when the fingertip was indented at rates from 0.2 to 16 mm/set were quite insensitive to changes in indentation velocity. Similar results were obtained on the forearm at indentation velocities of 0.4 to 16... | Skin; Indentation; Nerve impulses | 1983 |
| 50 |
 |
Christensen, Douglas A. | General formulation for connecting sources and passive lumped-circuit elements across multiple 3-D FDTD cells | A previous extension of the finite-difference time-domain (FDTD) method to include lumped-circuit elements is further extended to model lumped-element circuits connected across multiple FDTD cells. This formulation is needed to model many kinds of circuits, like those with a transistor or other ac... | Finite-difference time-domain method; Lumped-element circuit; Dielectric; Microstrip | 1996-02 |
