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Creator | Title | Description | Subject | Date |
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Capecchi, Mario R. | Hoxb8 is required for normal grooming behavior in mice. | Repertoires of grooming behaviors critical to survival are exhibited by most animal species, including humans. Genes that influence this complex behavior are unknown. We report that mice with disruptions of Hoxb8 show, with 100% penetrance, excessive grooming leading to hair removal and lesions. Add... | Aging; Alleles; Animals, Newborn; Behavior, Animal; Bone and Bones; Disease Models, Animal; Mice, Knockout Nerve Net | 2002-01-03 |
| 277 |
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Capecchi, Mario R. | Hoxc13 mutant mice lack external hair | Hox genes are usually expressed temporally and spatially in a colinear manner with respect to their positions in the Hox complex. Consistent with the expected pattern for a paralogous group 13 member, early embryonic Hoxc13 expression is found in the nails and tail. Hoxc13 is also expressed in vibri... | Filiform papillae; Homozygotes; Paralogous | 1998-01-01 |
| 278 |
 |
Carrier, David R. | Human flight and exercise in microgravity | Early experimenters in human flight learned, sometimes with fatal consequences, that the human body lacks the muscular power to fly (1). Indeed, the power demands are so great that only relatively small animals (less than 12 kg) are able to fly actively due to the interplay of morphologic scaling (m... | Human flight; Microgravity | 2000 |
| 279 |
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Baehr, Wolfgang | Human interstitial retinoid-binding protein. Gene structure and primary structure | Interstitial retinoid-binding protein (IRBP) is synthesized and secreted by rod photoreceptor cells into the interphotoreceptor matrix and is known to bind retinoids and fatty acids. We have used cDNA clones encoding human IRBP to isolate a 15-kilobase genomic fragment that encompasses the complete ... | Molecular Sequence Data; Eye Proteins; Retinol-Binding Proteins; Messenger RNA | 1989-05-15 |
| 280 |
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Sperry, John S. | Hydraulic architecture of palms | The water transport and storage system of palms is adapted to maintain the primary stem xylem functional over the life of the shoot, and in spite of severe drought. However, our structural information far exceeds our knowledge of vascular function, and these functional considerations bring more que... | Hydraulic architecture; Rhapis excelsa; Cavitation | 1995 |
| 281 |
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Linton, Matthew J. | Hydraulic conductivity, xylem cavitation, and water potential for succulent leaves of agave deserti and agave tequilana | Axial hydraulic conductivity (Kh) was measured for fresh, dehydrated, and rehydrated leaves of the Crassulacean acid metabolism (CAM) leaf succulents, Agave deserti and Agave tequilana. Dehydration of leaves at 35(o)C for several hours caused Kh to decrease, with a 50% decrease occurring at a leaf w... | Transpiration; Dehydrated; Drought | 2001 |
| 282 |
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Sperry, John S. | Hydraulic consequences of vessel evolution in angiosperms | We tested two hypotheses for how vessel evolution in angiosperms influenced xylem function. First, the transition to vessels decreased resistance to flow--often considered the driving force for their evolution. Second, the transition to vessels compromised safety from cavitation--a constraint emergi... | Cavitation; Resistivity; Perforation | 2007 |
| 283 |
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Sekercioglu, Cagan | Ibis quest | The day I arrived in Ethiopia, researcher Yilma Dellelegn Abebe of the Ethiopia Wildlife and Natural History Society (EWNHS) was just leaving the capital city, Addis Ababa, to search for three Northern Bald Ibises in a remote, roadless area of the country. These critically endangered birds had been ... | | 2007-01-01 |
| 284 |
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Seger, Jon | Ideas in ecology | The word "ecology" means different things to different people. For example, during the last 25 years or so the word has been used to label attitudes, life-styles, consumer goods, political parties, and college courses. In the 1960s one university renamed its "Home Economics" course "Home Ecology."... | Behavioral ecology; Population ecology | 1986 |
| 285 |
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Olivera, Baldomero M. | Identification and characterization of a Ca2+-sensitive nonspecific cation channel underlying prolonged repetitive firing in Aplysia neurons | The afterdischarge of Aplysia bag cell neurons has served as a model system for the study of phosphorylation-mediated changes in neuronal excitability. The nature of the depolarization generating the afterdischarge, however, has remained unclear. We now have found that venom from Conus textile trig... | Ca21-activated nonspecific cation channel; Slow inward current; Ion channel modulation; Afterdischarge; Bursting; Aplysia bag cell neurons; Conus textile; Neurotoxins | 1996 |
| 286 |
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Beckerle, Mary C. | Identification of a new protein localized at sites of cell-substrate adhesion | A new protein found at sites of cellsubstrate adhesion has been identified by analysis of a nonimmune rabbit serum. By indirect immunofluorescence this serum stains focal contacts (adhesion plaques) and the associated termini of actin filament bundles in cultured chicken cells. | Actin; Nonimmune rabbit serum; Polypeptide | 1986 |
| 287 |
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Olivera, Baldomero M. | Identification of a novel pharmacophore for peptide toxins interacting with K+ channels | қM-conotoxin RIIIK blocks TSha1 K+ channels from trout with high affinity by interacting with the ion channel pore. As opposed to many other peptides targeting K+ channels, қM-RIIIK does not possess a functional dyad. In this study we combine thermodynamic mutant cycle analysis and docking calc... | Conotoxins; Peptide toxins; қM-conotoxin RIIIK; Pharmacophore | 2005 |
| 288 |
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Olivera, Baldomero M. | Identification of Conus peptidylprolyl cis-trans isomerases (PPIases) and assessment of their role in the oxidative folding of conotoxins | Peptidylprolyl cis-trans isomerases (PPIases) are ubiquitous proteins that catalyze the cis-trans isomerization of prolines. A number of proteins, such as Drosophila rhodopsin and the human immunodeficiency viral protein HIV-1 Gag, have been identified as endogenous substrates for PPIases. However, ... | | 2010 |
| 289 |
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Capecchi, Mario R. | Illegitimate cre-dependent chromosome rearrangements in transgenic mouse spermatids. | The bacteriophage P1 Cre/loxP system has become a powerful tool for in vivo manipulation of the genomes of transgenic mice. Although in vitro studies have shown that Cre can catalyze recombination between cryptic "pseudo-loxP" sites in mammalian genomes, to date there have been no reports of loxP-si... | Chromatin; Female; Mice, Inbred C57BL; Phenotype | 2000-12-05 |
| 290 |
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Bowling, David R. | Impacts of anthropogenic emissions and cold air pools on urban to montane gradients of snowpack ion concentrations in the Wasatch Mountains, Utah | Urban montane valleys are often characterized by periodic wintertime temperature inversions (cold air pools) that increase atmospheric particulate matter concentrations, potentially stimulating the deposition of major ions to these snow-covered ecosystems. We assessed spatial and temporal patterns o... | | 2014-01-01 |
| 291 |
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Sekercioglu, Cagan | Impacts of birdwatching on human and avian communities | Ecotourism can be a vehicle for community-based conservation if it is conducted with an emphasis on the well-being of local ecosystems and human communities. Birdwatchers form the largest group of ecotourists, and are, on average, well-educated, wealthy and committed. This makes them ideal ecotouris... | | 2002-01-01 |
| 292 |
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Ehleringer, James R. | Implications of CO2 pooling on δ13C of ecosystem respiration and leaves in Amazonian forest | The carbon isotope of a leaf (δ13Cleaf) is generally more negative in riparian zones than in areas with low soil moisture content or rainfall input. In Central Amazonia, the small-scale topography is composed of plateaus and valleys, with plateaus generally having a lower soil moisture status ... | Amazonia; Carbon dioxide; Oxygen isotope ratio; Respiration; Soil water content | 2008 |
| 293 |
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Sekercioglu, Cagan | Importance of Ethiopian shade coffee farms for forest bird conservation | Coffee is the most important tropical commodity and is grown in high-priority areas for biological conservation. There is abundant literature on the conservation value of coffee farms internationally, but there has been little research on this topic in Africa. Ethiopia is a diverse and little-studie... | | 2014-01-01 |
| 294 |
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Jorgensen, Erik | Improved Mos1-mediated transgenesis in C. elegans | The ability to add or delete genes to the genome of genetic model organisms is essential. Previously, we developed methods based on the Mos1 transposon1 to make targeted transgene insertions (Mos1-mediated Single Copy transgene Insertions, MosSCI2) and targeted deletions (Mos1-mediated deletions, Mo... | | 2012-01-01 |
| 295 |
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Capecchi, Mario R. | In vivo and in vitro tissue-specific expression of green fluorescent protein using the cre-lox system in mouse embryonic stem cells. | Embryonic stem cells (ES) are pluripotent and may therefore serve as a source for the generation of specific cell types required for future therapies based on cell replacement. The isolation of defined cell populations from a certain lineage or tissue is a prerequisite for the analysis of the potent... | Animals; Cell Differentiation; Cells, Cultured; Gene Transfer Techniques; Mice, Transgenic | 2005-10-23 |
| 296 |
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Loftus, Patrick David; Rosenblatt, Jody; Eisenhoffer Jr., George Thomas | Induced pressure promotes extrusion and transient polyp formation in MDCK monolayers to maintain homeostasis | In the human body about 100,000 cells are produced every second by mitosis and a similar number die by apoptosis. What happens if too much death occurs? What happens if too little death occurs? How are dying epithelial cells removed? | Extrusion; MDCK monolayers; Polyp formation; Trapeze Interactive Poster | 2010-03-15 |
| 297 |
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Potts, Wayne K. | Infection-dependent phenotypes in MHC-congenic mice are not due to MHC: can we trust congenic animals? | Congenic strains of mice are assumed to differ only at a single gene or region of the genome. These mice have great importance in evaluating the function of genes. However, their utility depends on the maintenance of this true congenic nature. Although, accumulating evidence suggests that congenic ... | Strains; Mutations; Pathogen | 2004 |
| 298 |
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Clayton, Dale H. | Influence of bill shape on ectoparasite load in Western Scrub-Jays | Populations of the Western Scrub-Jay (Aphelocoma californica) have bills specialized for feeding in their respective habitats. Populations in oak habitat have hooked bills, whereas those in pinyon habitat have pointed bills with a reduced maxillary overhang. Work on other bird species shows that the... | Ectoparasite load; Bill shape; Aphelocoma californica | 2002 |
| 299 |
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Adler, Frederick R. | Information collection and spread by networks of patrolling ants | To study how a social group, such as an ant colony, monitors events occurring throughout its territory, we present a model of a network of patrolling ants engaged in information collection and dissemination. In this network, individuals follow independent paths through a region and can exchange sign... | Patrolling network; ant colony; information-gathering | 1992 |
| 300 |
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Capecchi, Mario R. | Initiation of E. coli proteins. | Recent experiments and theoretical arguments suggest that formylmethionyl sRNA is employed as an initiator of protein synthesis. Studies also indicated that other phage proteins synthesized in the in vitro system were initiated with formylmethionine. These observations provided a basis for believin... | Alanine; Chromatography, Paper; Dipeptides | 1966-06 |
