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TitleDescriptionSubjectCollection
251 Fetal cotyledons (normal term human placenta)After dissection of one placental lobe several cotyledons (2) are visible in (A). Each fetal cotyledon (2) consists of a main stem villus (1) and all its branches. (B) After trypsinization of a cotyledon the tree of arborisation of the stem villus and its branches becomes visible. (By courtesy...placenta; cotyledon; villus; trypsinizationPoja Histology Collection - Placenta
252 Macroscopy of fetus (human)The fetus (1)is completely wrapped in a shiny transparent amnion (2) and closely associated with the brown-coloured placenta (3). (By courtesy of the Museum of Anatomy and Pathology, University Medical Center, St. Radboud University, Nijmegen, The Netherlands)fetus; placenta; amnionPoja Histology Collection - Placenta
253 Thymus (human, newborn)Stain: Hematoxylin & eosin. The thymus is a bilobed lymphoepithelial organ derived as an outgrowth from the third branchial (pharyngeal) pouch, and situated in the anterior mediastinum. Each lobe is divided into multiple lobules by fibrous septa or trabeculae (3). Each lobule consists of an outer co...epithelioreticular cells (ERC); thymus hormones; Hassalls corpuscle ; lymphoid tissuePoja Histology Collection - Lymphatic Tissues and Organs Subset
254 The effect of cyclophosphamide on CD3-thymocytes in thymus (rat)Stain: Immunoperoxidase staining with diaminobenzidin (DAB) and hematoxylin counterstained on frozen section.. A single injection with cyclophosphamide (CP, 70 mg/ml) induces a transient cortical involution after 4 days, i.e. the dark-blue stained cortex and the lightly stained medulla in normal thy...cyclophosphamide; CD3 monoclonal antibody; lymphoid tissue ; immunosuppressionPoja Histology Collection - Lymphatic Tissues and Organs Subset
255 Follow-up of the process of diapedesis through stratified epithelium of the palatine tonsil (gut-associated lymphatic tissue or GALT) (human)Stain: (A, C) Azan and (B, D) anti-keratin-antibody and immunoperoxidase staining using diaminobenzidin (DAB) on frozen section, counterstained with hematoxylin. (1) (keratinized) stratified squamous epithelial cells. (2) between desquamated epithelial cells the spaces are filled with infiltrated l...stratified squamous epithelial cells; GALTPoja Histology Collection - Lymphatic Tissues and Organs Subset
256 Thymus cortex (rat, young adult)Electron microscopy. Within the thymic cortex a type II epithelioreticular cell or so-called (sometimes multinucleated) thymic nurse cell (TNC) shows a characteristic electron-light nucleus and nucleolus (1). The branches are squeezed between the thymocytes (2). In the cytoplasm a variety of empty a...MHC class I and II expression; epithelioreticular cell type I and II; thymic nurse cell TNC; lymphoid tissuePoja Histology Collection - Lymphatic Tissues and Organs Subset
257 Corpuscles in thymus (human, puberty)Stain: Hematoxylin. A: Several thymic (Hassall's) corpuscles (*) of varying sizes within the medulla (1). The Hassall bodies are surrounded by recognizable flattened cells showing keratohyalin granules. The outer shell consists of more layers of close packed concentrically arranged cells with light-...thymic corpuscle (Hassalls); epithelioreticular cell (ERC); thymus medulla; lymphoid tissuePoja Histology Collection - Lymphatic Tissues and Organs Subset
258 Scheme of the thymus during ageing (human)Physiological changes in the course of human ageing lead to almost complete degeneration of the thymus (age involution). Both cortex and medulla become depleted of lymphocytes, and the distinction between both layers gradually becomes less. The remaining reticular meshwork of connective tissue is gr...thymus involution; thymus development; thymus age; lymphoid tissuePoja Histology Collection - Lymphatic Tissues and Organs Subset
259 Spleen with central artery in lymphatic nodule (human)Stain: Azan. A longitudinally cut central artery (1) of a lymphatic nodule or follicle, (white pulp) is invested by a distinct lymphatic sheath (PALS) composed of concentric layered T lymphocytes) (2). The red pulp consists of open venous sinusoids (4) and splenic cords (5, Billroth) with macrophage...central artery; PALS; sinusoid ; BillrothPoja Histology Collection - Lymphatic Tissues and Organs Subset
260 Survey of spleen (human)Stain: Trichrome (Goldner). Encapsulated by a relatively thin fibroelastic capsule (1), the splenic parenchyma shows a preferable peripheral location of the red pulp (3). There are many secondary lymphatic nodules (2) as part of the white pulp, all showing a clear germinal centre. The red pulp is a ...white pulp; red pulpPoja Histology Collection - Lymphatic Tissues and Organs Subset
261 Survey of the border of splenic white and red pulp (rat)Electron microscopy. Megakaryocytes (1) are commonly found in adult spleen of rodents. In this area they are located just at the border of the white pulp (WP) with a variety of lymphocytes (3). In the splenic cords (Billroth) of the red pulp (RP) erythrocytes (2) are found.electron microscopy; white pulp; BillrothPoja Histology Collection - Lymphatic Tissues and Organs Subset
262 Scheme of blood circulation in the red pulp in the spleenA. closed circulation B. open circulation A. The route of closed circulation proposes that blood empties from the capillaries directly into the splenic sinus. The central artery bifurcates into penicillar arterioles (1) and the blood slowly enters ensheathed capillaries, surrounded by agg...white pulp; marginal zone; red pulp; open circulationPoja Histology Collection - Lymphatic Tissues and Organs Subset
263 Accidental involution of thymus (mouse, malaria infection)Stain: Hematoxylin & eosin. Due to the infection with malarial parasites (Plasmodium berghei in mice) a steroid-related involution of the thymus is induced in mice within 14 days. A: normal thymus with cortex (2) and medulla (1). B: There is still a quite large remnant of the original thymus tissue ...malaria infection; thymus involution; Plasmodium berghei; lymphoid tissuePoja Histology Collection - Lymphatic Tissues and Organs Subset
264 Border of a marginal zone in spleen (rat)Stain: Immunoelectron microscopy (gold labeling of heparan sulfate in Lowicryl embedding, using the single chain antibody HS4C3). The zone of red pulp immediately surrounding a lymphatic nodule is called the marginal zone (perilymphoid zone) and is composed of a scaffold of basal lamina material w...marginal zone; immuno electron microscopy; heparan sulfate; dendritic cellPoja Histology Collection - Lymphatic Tissues and Organs Subset
265 Scheme of the medullar changes in lymph node after antigen stimulationUpon antigenic stimulation the reticular cells that line the medullar sinusoids start to phagocytise the antigens (i.e. infective agents) and change from small tiny stellate cells into swollen large cells due to phagocytosis. They detach from the medullar sinus wall. After ten days the situation has...follicle; antigen stimulation; scheme; germinal centerPoja Histology Collection - Lymphatic Tissues and Organs Subset
266 Appendix ('gut-associated lymphatic tissue' or GALT) (human)A large nodule in the appendix extends through the proper lamina (1) and submucosa. The nodule is similar to that found in a lymph node with germinal centre (2) and darker-stained cap (crescent) (3) orientated towards the lumen of the gut showing a flattened dome area covered with discontinuous epit...GALT; follicle; lymphoid tissuePoja Histology Collection - Lymphatic Tissues and Organs Subset
267 : Localization of ED3-positive subpopulation of macrophages in spleen (rat)Stain: Immunohistochemistry of Vector red staining using the antibody ED3. The survey in (A) shows that the ED3-positive macrophages are found as a ring in the marginal zone border, as well as spread in the red pulp area (2). The cells are sometimes referred as marginal metallophilic macrophages. T...metallophilic macrophages; ED3 antibody; marginal zonePoja Histology Collection - Lymphatic Tissues and Organs Subset
268 Spleen with central artery in lymphatic nodule (human)Stain: A: Silver stain (Gomori). B: Trichrome (Goldner). In A: the reticular fibers (2) around the PALS (periarteriolar lymphatic sheath) and continuing in and around the marginal zone are stained black, illustrating the reticular framework of the lymphatic nodule. (1) central arteries. (4) red pulp...central artery; PALS; white pulp; T cellsPoja Histology Collection - Lymphatic Tissues and Organs Subset
269 Macrophage-sheathed capillaries in spleen (human)Azan. The branching of each penicillar arteriole gives rise to capillaries and a slow-down of the blood stream. In certain regions monocyte-derived macrophages leave the capillary and enter its wall where they develop into macrophages. Together with the present reticular cells these cell accumulatio...macrophage-sheathed capillaries; penicillar arterioles; sinusoidPoja Histology Collection - Lymphatic Tissues and Organs Subset
270 Medulla of thymus (human, puberty)Stain: Hematoxylin. The light-stained medulla consists of a loosened framework of epithelial reticular cells, macrophages, thymocytes and capillaries. Accumulations of a specialized type of epithelial reticular cells (1) are localized between the thymocytes. These clusters represent precursors of fu...thymic corpuscle (Hassalls); epithelioreticular cell (ERC); thymus medulla; lymphoid tissuePoja Histology Collection - Lymphatic Tissues and Organs Subset
271 Splenic venous sinusoid in red pulp (rat)Immunoelectron microscopy (gold labeling of heparan sulfate in Lowicryl embedding, using the single chain antibody HS4C3). (1) shows the open lumen of a venous sinusoid filled with few electron-dense erythrocytes and lining cells (2). (3) marks a neutrophilic granulocyte. (4) points to the diaped...sinusoid; immuno electron microscopy; heparan sulfatePoja Histology Collection - Lymphatic Tissues and Organs Subset
272 Secondary lymphatic nodule in the spleen (human)Stain: Trichrome (Goldner). A: Survey of a follicle in the spleen. B: a higher magnification of a similar section shows part of a lymphatic nodule (follicle, white pulp) with cross-sections of the central artery (6). (1) germinal centre (filled with reticular cells, B-memory lymphocytes and macroph...white pulp; PALS; germinal center; marginal zonePoja Histology Collection - Lymphatic Tissues and Organs Subset
273 Immunoperoxidase stained CD8 positive T cells in spleen (rat)Stain: Immunoperoxidase staining using diaminobenzidin (DAB)/ hematoxylin counterstained on frozen section with anti-CD8 antibodies. A, B and C show brown-stained CD8-positive T cells or Tc cells at different enlargements. The CD8 Tc/s cells are localised predominantly in the PALS area (1), while th...CD8 lymphocytes; immunohistochemistry; PALSPoja Histology Collection - Lymphatic Tissues and Organs Subset
274 Thymus (human, fetus)Stain: Silver stain (Gomori). Reticular fibers are demonstrated in the interlobular septa in the thymic cortical area (2) of this lobule. In the medulla (1) the more loosened reticular framework is more distinct. The reticular fibers are produced by the epithelioreticular cells and are particular ...thymic corpuscle (Hassalls); epithelioreticular cell (ERC); reticular fibers; lymphoid tissuePoja Histology Collection - Lymphatic Tissues and Organs Subset
275 Thymus cortex (rat, young adult)Electron microscopy. Type I epithelioreticular cells (4) separate connective tissue compartment (capsule, trabeculae, blood vessels) from the thymic parenchyma. At the left the capsule is bordered by a basal lamina (4a) of two projections (4) of type I epithelioreticular cells. Close to them, part o...lymphoid tissue ; epithelioreticular cell type I; diapedesisPoja Histology Collection - Lymphatic Tissues and Organs Subset
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