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226 Blumenthal, Donald K.Characterization of the phosphotyrosyl protein phosphatase activity of calmodulin-dependent protein phosphatase.Calmodulin-dependent protein phosphatase from bovine brain and heart was assayed for phosphotyrosine and phosphoserine phosphatase activity using several substrates: 1) smooth muscle myosin light chain (LC20) phosphorylated on tyrosine or serine residues, 2) angiotensin I phosphorylated on tyrosine,...Metabolism; Phosphatase Activity1986-07-25
227 Poulter, Charles Dale; Davis, Darrell R.15N-labeled tRNA. Identification of 4-thiouridine in Escherichia coli tRNASer1 and tRNATyr2 by 1H-15N two-dimensional NMR spectroscopy.Uridine is uniquely conserved at position 8 in elongator tRNAs and binds to A14 to form a reversed Hoogsteen base pair which folds the dihydrouridine loop back into the core of the L-shaped molecule. On the basis of 1H NMR studies, Hurd and co-workers (Hurd, R. E., Robillard, G. T., and Reid, B. R. ...Magnetic resonance spectroscopy1986-09-15
228 Thomas, Kirk R.; Capecchi, Mario R.Introduction of homologous DNA sequences into mammalian cells induces mutations in the cognate gene.Injection of homologous DNA sequences into nuclei of cultured mammalian cells induces mutations in the cognate chromosomal gene. It appears that these mutations result from incorrect repair of a heteroduplex formed between the introduced and the chromosomal sequence. This phenomenon is termed 'heter...Animals; Cell Line; Drug Resistance, Microbial; Fibroblasts; Mice; Models, Genetic; Neomycin; Plasmids1986-11-06
229 Gesteland, Raymond F.; Atkins, John F.; Weiss, Robert B.Slippery runs, shifty stops, backward steps and forward hops: -2, -1, +1, +2, +5 and +6 Ribosomal frameshiftingFrameshift mutations frequently express residual levels of gene activity; that is, they are often leaky. This leakiness can be used as a tool to define the functional components that affect the reading frame during gene expression. Recent technological advances in the capability to efficiently bu...Molecular Sequence Data; Mutation; RNA, Transfer; Frameshifting1987
230 Warner, Homer R.Use of the HELP Clinical Database to Build and Test Medical KnowledgeBiomedical Informatics1987
231 Warner, Homer R.Bringing HELP to the Clinical Laboratory - Use of an Expert System to Provide Automatic Interpretation of Laboratory DataBiomedical Informatics1987
232 Warner, Homer R.Computer-Assisted Pregnancy ManagementBiomedical Informatics1987
233 Warner, Homer R.Odyssey: A Program to Access Medical KnowledgeBiomedical Informatics1987
234 Warner, Homer R.A Decision-Driven System to Collect the Patient HistoryBiomedical Informatics1987
235 Warner, Homer R.HELP Decision Support on the MacintoshBiomedical Informatics1987
236 Bernstein, Paul S.Biochemical characterization of the retinoid isomerase system of the eyeWe have previously shown that membranes from the retinal pigment epithelium can transform added all-trans-retinol into a mixture of 11-cis-retinoids, demonstrating the "missing reaction" in the visual cycle for the first time (Bernstein, P. S., Law, W. C., and Rando, R. R. (1987) Proc. Natl. Acad. S...Hydrogen-Ion Concentration1987
237 Warner, Homer R.KESS: Knowledge Engineering Support SystemBiomedical Informatics1987
238 Gardner, Reed M.Monitoring Direct Blood Pressure Algorithm EnhancementsBiomedical Informatics1987
239 Gardner, Reed M.Standardization of Spirometry - 1987 UpdateBiomedical Informatics1987
240 Varner, Michael W.Abnormal pregnancy sonogram: selective indication for fetal karyotype.The inability to make a definitive diagnosis in the fetus with a sonographically identified abnormality often results in parental and physician uncertainty. An antenatal chromosome evaluation could resolve this uncertainty. Forty-one fetuses with an abnormal ultrasound examination were tested for ka...Chromosome Disorders; Pregnancy; Karyotyping; Abnormalities; Amniocentesis1987-01
241 Battin, Margaret P.Age-rationing and the just distribution of health care: Is there a duty to die?The author analyzes the argument that a policy involving distributive justice in the allocation of scarce health care resources, based on the strategy of rational self interest maximation under a veil of ignorance (Rawls/Daniels), would result in an age rationing system of voluntary, socially encour...Health care providers; Death; Euthanasia1987-01
242 Varner, Michael W.; Digre, Kathleen B.Cranial magnetic resonance imaging in eclampsia.Although the precise neuropathologic basis for eclamptic convulsions remains unclear, intracranial hemorrhage is frequently associated with fatal cases. Magnetic resonance imaging (MRI) is a recently developed neuroimaging technique that appears superior to other processes for defining intracranial ...Eclampsia; Brain Edema; Cranial Magnetic Resonance Imaging1987-09
243 Blumenthal, Donald K.Rabbit skeletal muscle myosin light chain kinase. The calmodulin binding domain as a potential active site-directed inhibitory domain.A synthetic peptide modeled after the calmodulin (CaM)-binding domain of rabbit skeletal muscle myosin light chain kinase, Lys-Arg-Arg-Trp-Lys5-Lys-Asn-Phe-Ile-Ala10-Val-Ser-Ala-Ala-+ ++Asn15-Arg-Phe-Glycyl amide (M5), inhibited the CaM-independent chymotryptic fragment of the enzyme, C35 (Edelman, ...Synthetic Peptide1987-09-05
244 Pepper, Ginette A.Improving geriatric drug therapy.Healthcare professional and society in general harbor ambivalent beliefs about drug therapy. Most of us anticipate that drugs will eventually control, or even cure many age-related diseases. On the other hand, there is a growing unease about the hazards of medications, which range from minor discomf...Aged1987-10
245 Warner, Homer R.Clinical Linkages: IAIMS at the University of UtahBiomedical Informatics1988
246 Warner, Homer R.ILIAD as an Expert Consultant to Teach Differential DiagnosisBiomedical Informatics1988
247 Warner, Homer R.A Decision Support Technology ClearinghouseBiomedical Informatics1988
248 Normann, Richard A.; Kolb, HelgaNeural organization of the retina of the turtle Mauremys caspica: a light microscope and Golgi studyThe organization of the retina of the turtle species Mauremys caspica, found in fresh water ponds of Israel, has been examined by light microscopical techniques including examination of fresh wholemount retina, one micron blue-stained vertical sections and Golgi-stained material. The anatomical find...Turtle Retina; Photoreceptors; Golgi Technique; Amarcine Cells1988
249 Warner, Homer R.Generation and Maintenance of ILIAD Medical Knowledge in a Hypercard EnvironmentBiomedical Informatics1988
250 Warner, Homer R.Clustered Knowledge Representation: Increasing the Reliability of Computerized Expert SystemsBiomedical Informatics1988
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